Basic Information

Gene Symbol
THAP2
Assembly
GCA_018420115.1
Location
JAFFZH010000756.1:5898-8499[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0062 0.68 11.1 0.2 2 23 233 255 232 255 0.96
2 13 0.0033 0.36 12.0 0.3 2 23 260 282 259 282 0.89
3 13 0.00075 0.083 14.0 1.4 2 23 307 328 306 328 0.94
4 13 0.022 2.5 9.3 4.2 2 23 334 356 333 356 0.97
5 13 7.4e-06 0.00082 20.3 3.2 3 23 370 390 369 390 0.99
6 13 7.5e-06 0.00084 20.3 1.6 1 23 403 425 403 425 0.99
7 13 8.2e-05 0.0091 17.0 2.4 1 23 433 455 433 455 0.98
8 13 5.2e-06 0.00058 20.8 1.0 1 23 461 483 461 483 0.98
9 13 0.00045 0.049 14.7 1.3 2 23 487 509 486 509 0.94
10 13 0.001 0.11 13.5 1.9 1 23 535 557 535 557 0.97
11 13 6e-05 0.0067 17.4 0.8 1 23 563 585 563 585 0.97
12 13 1.6e-05 0.0018 19.2 0.5 1 23 590 612 590 612 0.99
13 13 2.2 2.4e+02 3.1 0.4 1 11 620 632 620 637 0.67

Sequence Information

Coding Sequence
ATGTCTGGGTGCTCTGCGGTGGGTTGTTCGAACCGCGGCGACCGCGGTTACTTCATGAAAAGCTTTCCCCGAAACCCAGAACGTCGCGCTTTATGGGCGACGCAAATGAAAAGAGACAATTGGCAGCCCAACAATAATTGTCGCTTGTGCGAGGTACACTTCGACGATGATCAGTGGGAGAAAACGAGACAGGATGGCACTCGCAAGCTCAAATCCAACGCTGTTCCGACCCTGTTTCAACACTCTGAGAAAAGCACTGAAAGAAAAGCCAGAAAACGAAATCTTCCGGCGCTCAGTAACGACCCGAAAAGACTAAAGAACTTTGAGGAAAACGATCACAGCAGTTTGCAAAGAGAGGTTTCGTCACGCGATGTGCACCGAGAAGGCGAAGAAGGGCCTGTAGATGCTCGCTGCAGACTCTGTGCCACTAGAAACGGCACTAATTACACTTCGATATTCGGGGAATCCGATTTGGCGGAGAAGATCAGCAGATGTTTACCCGTTATAGTTTTGCACAGTGACAAACTGCCGCTTCACGTTTGCCAGCAGTGTTCGATCGACCTGAACGTCAGCTACAACTTGATCATGGGCTCTCTGAGGGCCGACTCTATCCTCAGATCAGAATTTCTTGAAACTTGTACCGAACTCGATTCCACCCCCAAAGATGAGCCCGTGTTCAGAATAAACGGTCCCATCCGATGCGACATGTGCGATCGTTACTTTGAGGACATGACCGAATTCGATACGCACATAGAAACTGAGCATCTACTCGGATGGCGGTGCGCCCTGTGCGATCACAGCTTCGAAACTAGGGAAGAACTCGTCGCTCACGAGACTCTGAGCCATTCTACAGAGATCGAGGCTTCCGGCAAGTCTGACGAGGAGCTGGAGAATTCAGAAATTAAAGAGACTGAATTGAGCTGCGTCGAGTGTGACATCGTCTTTGACGATCAGAAGCAGTTTCGGAAGCATCATACGCTCCACTTGCCAAAGCGGTTGAAATGCTCGATATGCCGCAAAAGGTGTTCTTCTATTTTTGAATACCTCAACCACAAGAGAACGATGCATCAGACTGCGAAGAGTAACGCAAGAAGCAGTGTGCACGGATGCAAATACTGCAAAAAAGTATTCATAAGGAAACAGCATCTGCTTGTTCATTTGAGGAAACATAAGAAAGAAATGCTTGACGATCCTTCCGTTACGGTTTACAAGTGCGTTACTTGTCCAAAAAAGTTTGTGGACAGATCGCTCTACCAGAAACACAGAAACGTGCACGATCCTGCTTGCTGGCACAAATATCGATGTTACACATGCGACAAGTCATTCATGGACCAATTCAAGCTCAGAATACATAGGTCTATTCACGACGGAGCAAAGCCTTATCGATGTGACGTCTGCGGTCACGCTTTCAACAGGAATGCGAATATGATCAGACATCGCGCTAAACATTTTGAACAGACTTGTCGTCATTGCCAAGTCGTATTCAAAAATAGCCCTTCGCTGAGGGTCCACCTGAAGGATGTACACGACGACACGCTAAATCCAAGGAGCACCTCTAAGGCAGTCAAGAAGGTGGGCGGAGGCGGCAGGGACAGCGATAAATTCATTTGCAGATACTGCGGAAAACAACTGACTTCGAACTGCTCGTTACTCGATCACGAACGAATACACACCGGAGATAAACCCTACGTCTGTGAACATTGCGGGAAATCCTTTAGAAGCGTAACTGCGAGATGGGATCACATGGTTCGTCACGAGAAGGGAAACTACGTGTGCGAATTGTGTGGAAAAATAATGAGCAACAGACTGAATCTTACACGCCATTTGAGACGTCACGCAGCTATAGAAGAGCGAAAGTTTGAGTGTAAAGAGTGTGGTAATGAACGCACATCTAGCACGAATTCATCGTTCGGACACCAGCAAGGAGGAAAAAAATAA
Protein Sequence
MSGCSAVGCSNRGDRGYFMKSFPRNPERRALWATQMKRDNWQPNNNCRLCEVHFDDDQWEKTRQDGTRKLKSNAVPTLFQHSEKSTERKARKRNLPALSNDPKRLKNFEENDHSSLQREVSSRDVHREGEEGPVDARCRLCATRNGTNYTSIFGESDLAEKISRCLPVIVLHSDKLPLHVCQQCSIDLNVSYNLIMGSLRADSILRSEFLETCTELDSTPKDEPVFRINGPIRCDMCDRYFEDMTEFDTHIETEHLLGWRCALCDHSFETREELVAHETLSHSTEIEASGKSDEELENSEIKETELSCVECDIVFDDQKQFRKHHTLHLPKRLKCSICRKRCSSIFEYLNHKRTMHQTAKSNARSSVHGCKYCKKVFIRKQHLLVHLRKHKKEMLDDPSVTVYKCVTCPKKFVDRSLYQKHRNVHDPACWHKYRCYTCDKSFMDQFKLRIHRSIHDGAKPYRCDVCGHAFNRNANMIRHRAKHFEQTCRHCQVVFKNSPSLRVHLKDVHDDTLNPRSTSKAVKKVGGGGRDSDKFICRYCGKQLTSNCSLLDHERIHTGDKPYVCEHCGKSFRSVTARWDHMVRHEKGNYVCELCGKIMSNRLNLTRHLRRHAAIEERKFECKECGNERTSSTNSSFGHQQGGKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00719470;
90% Identity
iTF_00719470;
80% Identity
iTF_00719470;