Basic Information

Gene Symbol
-
Assembly
GCA_949748255.1
Location
OX456526.1:147640970-147647231[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.018 1.8 10.6 0.1 3 23 47 67 45 67 0.96
2 16 0.017 1.8 10.6 4.4 1 23 73 96 73 96 0.94
3 16 0.44 46 6.2 0.2 3 23 101 123 100 123 0.85
4 16 0.028 3 9.9 0.1 1 22 131 152 131 152 0.94
5 16 1.6e-05 0.0017 20.1 0.8 1 23 160 182 160 182 0.96
6 16 0.00018 0.019 16.8 3.5 1 23 188 210 188 210 0.98
7 16 0.00011 0.012 17.5 1.3 1 23 216 238 216 238 0.95
8 16 10 1e+03 1.9 3.0 1 23 689 712 689 712 0.94
9 16 0.38 39 6.4 0.2 1 10 736 745 736 758 0.79
10 16 4.7 5e+02 2.9 4.3 1 22 766 788 766 790 0.89
11 16 0.27 28 6.8 1.3 3 23 796 817 796 817 0.96
12 16 0.2 21 7.2 0.3 2 21 829 848 828 849 0.91
13 16 0.00019 0.02 16.8 1.1 1 23 857 879 857 879 0.98
14 16 0.0028 0.3 13.1 2.5 1 23 885 908 885 908 0.95
15 16 9.9e-05 0.01 17.6 1.3 1 23 914 936 914 936 0.98
16 16 0.00064 0.067 15.1 1.1 1 21 942 962 942 963 0.95

Sequence Information

Coding Sequence
ATGTGGGAATCAGCTGATTGTGGCAATATGGCGGAGAAACACAAAgccGATCCTGATGCAGCTTCTACTTCTGCAGCTGCAGCCGCTGCCCAAGCTATGCTTGTTAAAATATCCACCGATGGCATGCCAAAACTATTTTGTCCCATTTGTAACAAAGCCCTGGTATCCTTGGCTGGCTATGTGAAACATCTTAGCAAACATGAACCTCCCGGGGGTTTTCTCTGCCGTTATTGTGACGCCCGTTTCTGCCATGACGAAGAATTGAAAAAACATCGTGAAACCGAACATACTACTATAGCCTGTCGTCTTTGTAAAGACGTAACATTTACTAATGAAGATGATTATAGAACCCATATACGTGATATTCATAAGGGAGTAGATCGCGAACTTTACAATTGTGAAAAATGTGGGGCAGCCTATAAGACAATTGAACCATATCGTAGACATATAGAAACTGAATGTGGTAAAAATAAACCATTTAAATGCGATAAATGTCCAATGGCATTTGTGACAAAGTACAATTTAAAGCAACACGTCGATAATCATTCCggtgaattgaaattttgttgcaGTTATTGTGGTAGAAATTTTAAACAGAAAGCCCGTTTAGTGGAACATGAAAGGACACATACAGGAGAAAAACCATATAAGTGTGATgTCTGTGGTAAAAGTTTTTCACATCGTGAAAGCATTGTTACCCATTCATCCATACATACTGGCATTCGGTTGGTAGAATGTAAATGTTGTTCTTCTCGGTTTTCTTGTTATTCCAATCTAATCAAACATAGACGTAATCGCCCCGATACTTGTGGTTTGCCAGAATTTGATCCACCCAGAAATAGAATAAGGAAGCATACATCTAGAAttcCTGCTACTTTAAATCCAACTTCTGAAATAAAAGtggtaaatcttaataaaattattaaacccAATGATCAGGTTAAAGTAGCGGCTTCGAAAAGAGAATTTCTTGATAAACCTAAAGTAAAACGAACAGCTAGAAAACGCACTGGTTTGGGACCAACGAAGATAGAACCACCAGTGACTGCAACAACACGTATAACACGTAAGAGAACACCTGCCAAGAAAAAAGTAATAGATTTTGATGATTTCGATGATGAAGATCTTAAGATAGAGCAAGATGATGAAGAATATTTACCAGAGGAAAAACCTTCTACatctacacccaaaaaagtGGAAGATTCTTTAGGACCACCACTTCTCAAGAAGGATGAGCCTCTACAAAATTTAACTACTACTCAATGGTCAGATGATAGCGATGATGATTTTGTACCCGATGTTGAACCCGAAGATTCCGATGAGGATGATGATAAAGACTTTAAACTATCAATGcccaatattaaaaaagaaacttgtGATTATTTCGACGATGAGGATATGGAAGTTACTAATATACAAATCGAACCTTTAGTAGAATTTGAATATAATCATTTGGATAATTATGATGCTGATATAAAAAATGAGAATGATGTAAAAAATGAGGATGATGAATCAAATTTGTTCGATGATAAAGATAAAATCTTGGAACATTTACTTAATGAAAATGATTATAATCACAAGAGTGATAAGGACaccttaaaaagaaaaagatcctATAAAGGCAGACAAAAAACTGCAGATTCAGATGATATTTTAGGAGAAACTGAAGTAGTCTTTATTAAATATGAAGATAGCGACGATAGTGATTTTGCCAAGGAAGATATATTACAGGATAAAAAACCGCagACACGTGTCGCTACCAAAGATGATGTTACTGATTGCTATGTGGTAGTTGAAGATGTTAAACATCGATTTCCAGAATTAAACGAAGAAAATAGCGTGAGGGTTCCGAAAAATGTTCAACCGTTTTTTGCTAAATCAGAAACAATGAAAAGATTCATTAAAAAACGTGGCAAATATCGTCCAAAAGCAAGAGGTAAATATCGTCCCAgaggaattaaaaaagaagagGACGTTAAACCAGTTAGATCATATCGTTCGGCAAAAATTTCCGCTGAACAATTAAAAGAACGTATGAAATTATTCCGTAAGCGTGATAGAATATATCATTGTCCACATTGtatcaaaatctattttatgcGTAAACCATATGAAAATCATTTACGCGATGAACACAATATAAGTGAAACAGAGTTAAAGGATATGTTCAAAGATGAAGTAGTGGATGTAGATGCAGATGATGTATTCAAATGTCCCATCTGTGATAAAATATATCTTATGGAAAAACGTTTAATTGATCATATACCCAAGCATGGACCAGATGGTACTTTGATTCACAAATGTCCCTGTTATTGTCAAATATATTTTGCTACGCGCGAAGAAGCCACAGCCCATTCACACGAGAAACATAGAGACATGTTATGGTGTGATATATGTGAGAAATTTTTGACTGGATGTGATGCATTAAAAACACACAGAGACCGTATACATGGTGATAAGGGATATAAACATTCTCGCAATTTGGTATGCATGAAATGTGGCAAGAAATTTTTGGGCAGAACCCAACTAACCGATCACGAACGTTCAGATTGTGGCCGTATACCATTATATCAATGTAAAGAATGCGGTAAATGTTTAACCACAGCGGGTATTTTAAAAACTCATATGTTACTACATGACGATGCTCGACCGTATCAATGTGATCAGTGtggtaaaacatttaaaattaaagcacaACACAAGACACATATTCAATATGCCCATACTGATCAGAAACGATTTAAATGCCATctgTGCCCTAAGGAATATCCTTATCGTGAGAGCTTATTAACACACATGTCAGTACATACTGGCATTAAACGTTTTATGTGTAACGGTTGTGGTAAACGTTTCACTTGTGTTTCCAATTTGCAGGCTCATCGTAAAGTTCAAgccgaaacttgtggtttattgcCTCTCAATGCTAAGGCTACACAGTATATGGGTGTACAAAAGGGTAATTTATTGATGGGTTCCAAGCCAGAACCAGGATTAGATTATGTTGAAACCCAAACAGTAGTAGCCAAAGAAGTTTACACTCATGATGTAGTCATGCCACAGGATGTTAATGCACATGGTAGATCTATGCCCCAAGACCAGTTATTAAGCGATGGTATACCTTTAAATTATGTTACTTCAGGATCTGAATTTATACTAATGTATAATAATAGAAATTAg
Protein Sequence
MWESADCGNMAEKHKADPDAASTSAAAAAAQAMLVKISTDGMPKLFCPICNKALVSLAGYVKHLSKHEPPGGFLCRYCDARFCHDEELKKHRETEHTTIACRLCKDVTFTNEDDYRTHIRDIHKGVDRELYNCEKCGAAYKTIEPYRRHIETECGKNKPFKCDKCPMAFVTKYNLKQHVDNHSGELKFCCSYCGRNFKQKARLVEHERTHTGEKPYKCDVCGKSFSHRESIVTHSSIHTGIRLVECKCCSSRFSCYSNLIKHRRNRPDTCGLPEFDPPRNRIRKHTSRIPATLNPTSEIKVVNLNKIIKPNDQVKVAASKREFLDKPKVKRTARKRTGLGPTKIEPPVTATTRITRKRTPAKKKVIDFDDFDDEDLKIEQDDEEYLPEEKPSTSTPKKVEDSLGPPLLKKDEPLQNLTTTQWSDDSDDDFVPDVEPEDSDEDDDKDFKLSMPNIKKETCDYFDDEDMEVTNIQIEPLVEFEYNHLDNYDADIKNENDVKNEDDESNLFDDKDKILEHLLNENDYNHKSDKDTLKRKRSYKGRQKTADSDDILGETEVVFIKYEDSDDSDFAKEDILQDKKPQTRVATKDDVTDCYVVVEDVKHRFPELNEENSVRVPKNVQPFFAKSETMKRFIKKRGKYRPKARGKYRPRGIKKEEDVKPVRSYRSAKISAEQLKERMKLFRKRDRIYHCPHCIKIYFMRKPYENHLRDEHNISETELKDMFKDEVVDVDADDVFKCPICDKIYLMEKRLIDHIPKHGPDGTLIHKCPCYCQIYFATREEATAHSHEKHRDMLWCDICEKFLTGCDALKTHRDRIHGDKGYKHSRNLVCMKCGKKFLGRTQLTDHERSDCGRIPLYQCKECGKCLTTAGILKTHMLLHDDARPYQCDQCGKTFKIKAQHKTHIQYAHTDQKRFKCHLCPKEYPYRESLLTHMSVHTGIKRFMCNGCGKRFTCVSNLQAHRKVQAETCGLLPLNAKATQYMGVQKGNLLMGSKPEPGLDYVETQTVVAKEVYTHDVVMPQDVNAHGRSMPQDQLLSDGIPLNYVTSGSEFILMYNNRN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00893162;
90% Identity
iTF_00893162;
80% Identity
-