Basic Information

Gene Symbol
-
Assembly
GCA_951802225.1
Location
OX637668.1:4744375-4753850[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 2.4 1.7e+02 3.5 4.3 1 23 125 148 125 148 0.96
2 13 0.24 17 6.6 1.3 1 11 212 222 212 230 0.85
3 13 0.0048 0.33 12.0 0.3 1 23 273 296 273 296 0.97
4 13 0.013 0.88 10.6 0.7 3 21 337 355 335 356 0.94
5 13 0.22 15 6.8 1.2 2 23 361 383 361 383 0.90
6 13 2.2 1.5e+02 3.6 2.1 1 14 391 404 391 407 0.81
7 13 0.88 62 4.8 3.2 1 23 852 874 852 874 0.97
8 13 0.028 1.9 9.6 2.5 3 23 989 1009 988 1009 0.93
9 13 0.014 1 10.5 1.0 2 23 1025 1046 1024 1046 0.96
10 13 1e-06 7.2e-05 23.5 1.1 1 23 1052 1074 1052 1074 0.98
11 13 0.048 3.4 8.8 2.5 1 23 1079 1101 1079 1101 0.96
12 13 0.00038 0.026 15.4 5.1 2 23 1108 1130 1107 1130 0.97
13 13 7.2e-05 0.005 17.7 1.2 3 23 1167 1188 1166 1188 0.97

Sequence Information

Coding Sequence
ATGTCTCCAAACTGGAGTCCTGTGGGTTTAGATAGATATGTCGCCAAACTGGAGTCCGGTGAGTATAGATATGTCTCCAAACTGGAGTCCGGTGAGTATAGATATGTCTCCAAACTGGAGTCCGGTGAGAGTAGAGAAATGTCTCCAAACTGGAGTCCTGTGGGAATAGATATGTCTACAAACTGGGGTCCGGTGGGTATAGATATGTCTCCAAGCTGGAGTCCAATGGGTATAGATATGTCTCCAAACTATATTCCGGAGGGCCACATAGCCTACTACTGCGTGAGTTACGAGGACGCCGTACGCGCCCTGTACACGAAGTGGCACCTGACGGCTGCGAACTCTCCATACAGGAAACGCGAGATATTATGCTTCAAGTGCTACCCGTGTTGGATGTATTTCAATCATTGCTCGGAGTTCCTAGCTCACTTGCAGTCCTCCCACGCGGCCGCGCCACTAGCGCTCGCCGCCGAGCTCGCCTCCGCCGGCTGCGGGACCATCGTCGCAGGACTCGGCCACGACGAATCCTCAACGGACGTAACGATATACAAAACGGAAAAAGCTTACGTGTGCAATAAGTGTAATAATGAAATCGCAACGTCTGCCTTACTGAGCTTTCATTTGAATAGTTCTTTCACTTGCGACGGCTGCGGAAGAGTTTTTAGCTGTAACGAGATAGTACAGCATTACGGGTTTTGCAGTAAATTTTTGGAGAAATACTACCCAAAGGCGTGCCCTTGTAGAAGTTCATTTAACTCTGCTAGAGAGTTAGCAGACCACCAACTTAGCTGCCTATACAAAAATGCTACTTTGGCCTTCAATTGCGTTGTATGCAGCTACACAGTCCCAACTTCGTACATGCTGGCCAAACACCAGATAACTACGCACGTTCCCAGATCAGACTTATTCGTTGACGGTGTAAAATTACTAAAGTGCAACCTGTGTCGTAATAAATTTGTCGGTCCGCTCGATTTGCATACTTGCCCGAAGAGGAGCGATGGGATTGACTGCAAGCACTGCGGTCTGAGGTTCCAAAGTCATATGTTGCTAACAGTTCATTTGAAGGCGCAGAAGAATAGAGAGTGCAATGTGTGCGGTAACAGGTTTTCCGTTTCGTGTCAGTTGGATATGCATAAAGTGATAAAACACAATTCTATACATAAGATTGTGTACCAGTGTACGCTTTGCAAGATGTGCTTCGATTACGAAAGACACATGGATATAATGAAGAAGTACGCGCTACACGAATGTACCAGTACGAGTTGTACGAGTTTGGTGAAAGAAAAGGAAAACCTCAGGAAGatGTTGGTCTACAAACACATGGGTTCCAGTTGGGCTTACGAGGACAACAAAGAACTCGATATAGAATCGAAAGACGCTCTGTTACCGGCCTTGCCAGTAACTTCAGTTACTGAAAACAAGGAAGGTGTAGCTTCAACCTCAAATATTGTTTCTGAAAAGAAAACTGCGAAGACCAGTCAATTAAAAGTATACAGCGGTAATATGCCCAAGATGTATATAAAtcaaagttttataaataaaattacaatcgGCCCAAGTAAGAACCCTGAGGTACACCCGATATATATCAGAGGTCTTTATTCGGAGAAGTCGAATGCCGTTGATAATTCTAGAAAGACGACAAAAGATTTTGTTGTACAAAGTAATAGATCTTTGTTGAAGAGAAAAGTGGACACGAAAAATAATGGAAGCAGATCACTTTTGAAGAAAATCGTTGATAAAATTGTTTATGAGGATGATGATGAGGAAATAATGAAAGTTATTCCGGaggttgtcaaaaaagttAATGCGGCTAAAGTTGATGAGAATAGAGTTGATGATCATAAAATAGatgaaaataaagttaaagttaaaatcgAAGAATCTATAGATTTTACGGAAACAAGTGTAGAGGGAAAAGATGATTTGGCTGCTTTCAATGATAATGGAATAGAAAATTTGAATATCAGGAACACGGATAATGCAACTATAAAAACCTATAGAGCACCTAAAACTCCTAATTTTACAATGGACAGTGACATATGTGATGTTGTTAAAACTGAAAAGGTAACTCCTGAAGACATAGCATCAGAAGAACTGACAACAATTAAATCTGAAActtcaaataaaaagttagagTTCACAGTTGAACCAGAattcaacgttgttgtaaaacaAGAAATAATAGAAACAACCGATGATGTGATAGAATATGACCCAGGAAAAGATATAAAGGAGGAAGTTTGCGAATTAATAACAAATTTGAAGACGGAAAATCCAAATTTTGGACCAGGATGTTCTTATGCAACTGAAGTTAGCGTAGACAAGGTTATAAGTGGATCTGATCTAttggatgaagtctattttaaaaaagatgtcaaaaatatcgaaaatgagAATAAAGCGCAAAAGAAAGCAAAGAAAAAAGATGAAAAAGCAAATAAGTCTCGAAAAATCTACAAGTGCCAAGGATGCAACTTCACTGGAGTACACAAGTTATACATTGCGCACAAAAAGAAATGCTGTCCCTACACTTCAAAGCCAGTTTTAACTTACAAATGCTTGCGCTGCGATTTGCAATGCTTCGACTTGAGAGATTACTTGAAACAcctcatcagacatggctaccAAAAATTCCAATGCCCCGCCTGCCAAGGTATCCAGGCGGGCAATCAGAAGTTAGCAGAACACGTGTTGCAGCACATAAAATCTAATTTCCGAAAGATAACCTATATAGACAAATCGAAAACGGATCAGACTAAAAAATTCCGCTGCAACAATTGCCGCTCTATTCTATGCCAGACAGAGTTCTTTTTGCATTGGCAGACTCATTTCGATCAACCACCCGAAAGGGAAGTCGAAATCGATTTAATAGACGATTCTGATCCGAACAAAATGACTCAAAAGGAAATTAACTCAATGCTGACTTTTATACAAGTTTCGAAAAGGTTGAAGGATCGAATGTGCTTCAAATGTAATCATGAGTTTGCGAGATTGAACGATTTGAAGCGACACTTCATAGAGCATTTGTTGGCCCACGCTTACTCGCAGAAGAAAAGGCTAAGAGAGTTAAGATGCCAATTGTGTAATGATGGATTTTCAAAGCCGGAGTTTTATAAGAAGCACATGCGAGATCATGCCTTATTACCATTGTACCAGTGTCAGATTTGCGATAAAGCGTTCAGTGACTCGTCGAATTTCGGGAAACACAAGAAAGTTCACAATTTGTTCGTTTTCGTTTGTGATATCTGCAGCAAGAAGTTTCAATGCAAGATGATGTTGGAGAAACATTTGCagGCCCACCAAACGACAGAGCCCCAGCAGTGCCAGCACTGCGGAAAGAAATTCTTCTTCCAAACGGCACTGAGACGGCACGAGAAGACCAAGCACTCCTTCCAGACGTTCTGCTGCAGGGTCTGCAGGCAGCGCTTCCCGAGCTGCAAGGAGAAGTGGATACACGAGTGGGAGgtacaCAAGGAGCGAAAGTTCGACGGCGACTGTCCAATTTGCAACAAGTCGTTTCGTAACTTTAGCGATACAAAAAATCATTTGAAAAGTGAACACGTTCCCGCGCATCGGGAGACTCAGAGTAGGCTGACGGTTTAG
Protein Sequence
MSPNWSPVGLDRYVAKLESGEYRYVSKLESGEYRYVSKLESGESREMSPNWSPVGIDMSTNWGPVGIDMSPSWSPMGIDMSPNYIPEGHIAYYCVSYEDAVRALYTKWHLTAANSPYRKREILCFKCYPCWMYFNHCSEFLAHLQSSHAAAPLALAAELASAGCGTIVAGLGHDESSTDVTIYKTEKAYVCNKCNNEIATSALLSFHLNSSFTCDGCGRVFSCNEIVQHYGFCSKFLEKYYPKACPCRSSFNSARELADHQLSCLYKNATLAFNCVVCSYTVPTSYMLAKHQITTHVPRSDLFVDGVKLLKCNLCRNKFVGPLDLHTCPKRSDGIDCKHCGLRFQSHMLLTVHLKAQKNRECNVCGNRFSVSCQLDMHKVIKHNSIHKIVYQCTLCKMCFDYERHMDIMKKYALHECTSTSCTSLVKEKENLRKMLVYKHMGSSWAYEDNKELDIESKDALLPALPVTSVTENKEGVASTSNIVSEKKTAKTSQLKVYSGNMPKMYINQSFINKITIGPSKNPEVHPIYIRGLYSEKSNAVDNSRKTTKDFVVQSNRSLLKRKVDTKNNGSRSLLKKIVDKIVYEDDDEEIMKVIPEVVKKVNAAKVDENRVDDHKIDENKVKVKIEESIDFTETSVEGKDDLAAFNDNGIENLNIRNTDNATIKTYRAPKTPNFTMDSDICDVVKTEKVTPEDIASEELTTIKSETSNKKLEFTVEPEFNVVVKQEIIETTDDVIEYDPGKDIKEEVCELITNLKTENPNFGPGCSYATEVSVDKVISGSDLLDEVYFKKDVKNIENENKAQKKAKKKDEKANKSRKIYKCQGCNFTGVHKLYIAHKKKCCPYTSKPVLTYKCLRCDLQCFDLRDYLKHLIRHGYQKFQCPACQGIQAGNQKLAEHVLQHIKSNFRKITYIDKSKTDQTKKFRCNNCRSILCQTEFFLHWQTHFDQPPEREVEIDLIDDSDPNKMTQKEINSMLTFIQVSKRLKDRMCFKCNHEFARLNDLKRHFIEHLLAHAYSQKKRLRELRCQLCNDGFSKPEFYKKHMRDHALLPLYQCQICDKAFSDSSNFGKHKKVHNLFVFVCDICSKKFQCKMMLEKHLQAHQTTEPQQCQHCGKKFFFQTALRRHEKTKHSFQTFCCRVCRQRFPSCKEKWIHEWEVHKERKFDGDCPICNKSFRNFSDTKNHLKSEHVPAHRETQSRLTV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-