Basic Information

Gene Symbol
L
Assembly
GCA_951802225.1
Location
OX637646.1:8539161-8562643[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 1.7e-06 0.00012 22.9 1.7 1 23 82 104 82 104 0.99
2 17 1.6 1.1e+02 4.0 4.8 1 23 110 132 110 132 0.97
3 17 1.9e-06 0.00013 22.7 3.1 1 23 138 160 138 160 0.99
4 17 2.9e-05 0.002 18.9 0.1 1 23 166 188 166 188 0.98
5 17 1e-05 0.00073 20.3 0.0 2 23 201 223 201 223 0.94
6 17 1.3 88 4.3 0.2 3 23 252 274 250 274 0.80
7 17 0.94 65 4.8 0.1 3 23 316 336 315 336 0.97
8 17 0.038 2.7 9.1 0.0 3 23 359 379 358 379 0.93
9 17 0.00098 0.068 14.1 0.3 1 23 387 410 387 410 0.95
10 17 0.036 2.5 9.2 0.1 1 23 415 438 415 438 0.92
11 17 0.00041 0.029 15.3 1.0 1 23 497 521 497 522 0.95
12 17 0.0011 0.078 14.0 0.0 2 23 576 597 575 597 0.96
13 17 0.065 4.5 8.4 0.0 1 23 605 627 605 627 0.97
14 17 1.7 1.2e+02 4.0 0.1 2 23 635 656 634 656 0.95
15 17 0.027 1.9 9.6 0.1 1 23 743 765 743 765 0.96
16 17 0.0029 0.2 12.6 0.1 1 20 773 792 773 795 0.95
17 17 0.44 31 5.8 0.3 1 23 802 824 802 824 0.95

Sequence Information

Coding Sequence
ATGATCATGCTATTCAAGGGGAACAGCAGCCGGCTCGAGCACCTCATTGAAAAAATCCAGGCGAACAAGGAGAACCACGACGTTTCACCAGACGAGATAAAAGAGGCCCTGGGCAGCGTGGGCAGCACGGCGGGCAGCTCCTGGCCGTCCTCGACGCCGGAGCCGTCGCCCTCCTCCACGCCGACCTCGGCGGACGCGGACGCCGAGCCGCCCTTCACCCTCGGGGCCACCGAGCACACGCCCTACCAGTGCCAATTCTGCGACAAGGCCTTCCCCAGGCTGTCTTACCTCAAGAAGCATGAGCAGaCGCATTCGGACCAAATGCCGTTCCGGTGCGAGTTCTGCGCGCGGCTGTTCAAGCACAAGCGGTCGCGCGACCGGCACGTCAAGCTGCACACCGGCGACCGCAAGTACCGCTGCGCGCACTGCGAGGCTGCTTTCTCCAGGAGtgaCCACCTGAAAATTCACATGAAGACTCACGACAACCAAAAGCCTTTCCAATGCACGGTGTGCAACCGCGGCTACAACACGGCGGCGGCGCTCACCTCGCACATGCAGGGGCACAAGCGCGAGCGCGAGCCGgagcgccgccgcgccgcgcgctgCCCGCGCTGCGGGGAGGGCTTCCGGAGGCCTGACGCCTTACAggcACACATGCTAGCTGCGCACGGAATGGAAATTCCAAGCATCCCGGCGACAAGTCCGCCGCGGCGCGTGTCGTCCCAGcccgccgcggccgccgcccTGCTCGCCTGCGTCTACTGCACTCGTGACACTTTCACAAGTCTGGAGCAGCTGCAACTCCACGTCAGAGCAGTTCACTCAGCCTTACTGGCGCCGGAGCAACCTGGCCCGACAGACCTCAGTAGGAAGGCAGATCCATCTCCGCCTGCGAAGCGCCAGCGCGTCTCTCCGACTAAACCTTTGAGCCCGAATACGCTACTGTGTAGCCAATGCGACGCTGCGCTTCCTGATTTCGAGTCTTTCCGCGTCCACGTGAAGGGCCACCTGGAGCGCGGGGCgggcggaggcggcggcggcgaggcgGGGGTGACGGCGGGCAGCCCGGCGCCGTGCCCGCACTGCGGCGCCACGttcgcggcggcggcggcggccgagcGCCACCTGGCGGCGCACTACCTGGCCGCCGCCTGCGAGTACTCGTGCCACAGCTGCGCGCGCTCCTTTCCCGCGCCCGACGACCTCCAGAAACATCTCATGGATCTACACGCACATCATCTTTATAGATGTTCCCTTTGCAAAGAAATATTTGACTCTAAAGTGGCTATACAGGTTCACTTCGCAGTGGGGCACAGCGGCGAGAGCAAGGTGTGGGTGTGCCGCGCGTGCGGGCCGGAGCCGGCGCTGCGCTCGGAGGCGGAGGGCGCGGCGCACGTGCGCGCAACGCACGCGGCGCGGCGGTGCGCGTGCGGCGCCGTGCTGGCCGGCGAGCGCGCGCTGCGGGCGCACGCGCACACGCACGCGCACTACCGCTGCCCCGCGCCCGCCTGCGAACACACCTTCGCTGTGCAGTACTTGCTGGAGCGGCACATGCAGTCCCATCACGGCTCGCCACAGATGCTAAACGGCGACACGCCGCGTCTTAAGCGGTCAGAAAACAACAACGCACCAGAGTCCGAAGAAGCTTGCTCTCCGTGCGCGGTGGGCGGCACCAACGGCACGGGCCCCGAGGAGCGGCGGCGCAAGAACGGCGCCGTGGCGCTGCAGTGCGCCTACTGCGGCGAGCGCGCGCGCAGTCGGGCCGAGCTGGAGGCGCACACGCGCGCGcacgcgggcgccgccgccgcgcgccacAAGTGCCTCATCTGCGACGAGGTGCTGCCGTCCGCCGCCGTGCTCGCCGAGCACAAGCTCACGCATTGCAAGGTGGTGGCCGGCGACTCGTGCTCCCGCTGCCGCGCGCGGCTGCCCTCGGAGGAGGCGTTCCTGAGCCACATGGCGCGGCACCAGGCGGCGCTGCCGGCGCCCTGCGTCGTTTGCCGGCAGACGCTGGGCTGCGAGGCGGAGGCGCGGCTGCACGCGCGCTTCCACCTGCGCCCCGCCGCCGACGAGCGCCAGTGCGCCTTCTGCCTGCGCGCGCTGCCCGAGGGCGAGGGCGGAGGTGGGGGCGGCGGGGGAGCGCGCGCCTGCTCCGCCTGCTACGCGCGCCACGCGGCCCGGGACTCGACGCCGGGGCCGGctgcgggcgcgggcgcgggcgcggagCACGAGTGCCGGCTGTGCGGGCGCGCGCTGGAGTCTGCAGCGCGCCTGCAGGCGCACCTCATCGAGCACACGTTCGCGGGCGCGGGCAGCTACACGTGCTACCTGTGCTCGGCCGTGTTCACGTCCGCTGCCGGCCTGCAGCGCCATCTGCCGGAgcacgccgccgcgccgctgccCTACGACTGCGCGAGGTGTCCTCTCAAATTCTTCTTCAGAGCCGAGCTGGACAATCACTCGTTGGTGCACTTGGAAGAAGCCGAGTTGGCACAGAGAGCGTTTTATGAGGCGTACGCGCGCGGTGCCGCATGGGCAGCTCTAGTTCCTCGGGAATCACCAATGGGTCTTATAGAAGAAGTTAAGAAGGAGCCAGAGGTAAAGGAAGAGAAAAATGATGAGTACATAGAGGTGGGATCCCCCCCGCCcctgccaccgccgccgccgccgcaggcctcgccgccgcccgcgccgcccgcgccctccCCGCACTCCCCGCACTCCCCGCCCGCGCTCGTCAAGCAGGAGCGGCCGGATGAAGAGTGA
Protein Sequence
MIMLFKGNSSRLEHLIEKIQANKENHDVSPDEIKEALGSVGSTAGSSWPSSTPEPSPSSTPTSADADAEPPFTLGATEHTPYQCQFCDKAFPRLSYLKKHEQTHSDQMPFRCEFCARLFKHKRSRDRHVKLHTGDRKYRCAHCEAAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQGHKREREPERRRAARCPRCGEGFRRPDALQAHMLAAHGMEIPSIPATSPPRRVSSQPAAAAALLACVYCTRDTFTSLEQLQLHVRAVHSALLAPEQPGPTDLSRKADPSPPAKRQRVSPTKPLSPNTLLCSQCDAALPDFESFRVHVKGHLERGAGGGGGGEAGVTAGSPAPCPHCGATFAAAAAAERHLAAHYLAAACEYSCHSCARSFPAPDDLQKHLMDLHAHHLYRCSLCKEIFDSKVAIQVHFAVGHSGESKVWVCRACGPEPALRSEAEGAAHVRATHAARRCACGAVLAGERALRAHAHTHAHYRCPAPACEHTFAVQYLLERHMQSHHGSPQMLNGDTPRLKRSENNNAPESEEACSPCAVGGTNGTGPEERRRKNGAVALQCAYCGERARSRAELEAHTRAHAGAAAARHKCLICDEVLPSAAVLAEHKLTHCKVVAGDSCSRCRARLPSEEAFLSHMARHQAALPAPCVVCRQTLGCEAEARLHARFHLRPAADERQCAFCLRALPEGEGGGGGGGGARACSACYARHAARDSTPGPAAGAGAGAEHECRLCGRALESAARLQAHLIEHTFAGAGSYTCYLCSAVFTSAAGLQRHLPEHAAAPLPYDCARCPLKFFFRAELDNHSLVHLEEAELAQRAFYEAYARGAAWAALVPRESPMGLIEEVKKEPEVKEEKNDEYIEVGSPPPLPPPPPPQASPPPAPPAPSPHSPHSPPALVKQERPDEE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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