Basic Information

Gene Symbol
-
Assembly
GCA_035586675.1
Location
JAXIUT010000021.1:9492916-9503248[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.022 2.9 9.6 0.1 2 23 827 849 826 849 0.91
2 11 0.0002 0.025 16.1 0.3 2 23 903 924 902 924 0.97
3 11 0.037 4.8 8.9 1.5 3 22 1039 1058 1038 1058 0.96
4 11 0.033 4.2 9.1 0.2 1 20 1177 1196 1177 1198 0.93
5 11 0.48 61 5.4 1.8 2 19 1224 1241 1223 1242 0.95
6 11 0.4 52 5.6 0.2 1 23 1267 1290 1267 1290 0.97
7 11 0.022 2.8 9.6 0.6 1 23 1342 1364 1342 1364 0.97
8 11 0.0028 0.36 12.4 0.7 3 23 1664 1685 1662 1685 0.93
9 11 0.0052 0.67 11.6 0.3 1 23 2088 2111 2088 2111 0.97
10 11 1.2 1.5e+02 4.1 0.9 1 23 2121 2146 2119 2146 0.85
11 11 5.3e-05 0.0068 17.9 0.4 1 23 2148 2170 2148 2170 0.98

Sequence Information

Coding Sequence
ATGAGTGATGATGACGCATCACAATGTCAAAGAACTCAACCTTTTGCAGGAAATTGTAGTAGGACTAAACCATACTTGAAGTCAGTTAAAACTAAAGTTTCAAATGCATCTGAAACTAGCACTAATTCAATTAACGATGAAATATCATTGGAAATAGTAAGCGATCCTGTAAtatcaaatgaaattgataaagGAAGGCAAGATATTAGTGATAAAGATCAAGACATTCCAGtcaatgaagaaaatgaaatagttgAACCAGTCACTGATGTCACTagtGCAGCATTACCTTCttctaaaaaagcaaaaacaaaGACTTCTTGTGAATCAAAAGCATCTGCTGATAAAACAATACCAACTACTGCCGTTTCACCAGGAAAAACCATTTGCTCACTACTTTCACTAAACTGCAAAAAACATGACCATCATCATCATAATCATCAACAAGAGCAACAAagtataattaactttaatttgaaacaagATGCATATGTTTTACTTGATCGTTTAGAGCTTATGACAGATCCACTAGTTCTCAACTACCTCAAGAAGACTGAtagaattagtaaaataaaagaagacccatcacctaaaaaaaataaaaataacttgaatgAATCTGACAAGAGTTCAGTTCACAAAAATCAAAAGCAGGATGTAGCTCATTCAAATAATGAAGAATCCACAGCCAAAGATGATACCCCTAAATTgaacaaagaagaaaaactaattgaaGCAAACTTAAAAGATCATTGTGCAGCaactgtaaaagaaataagtgAAATCATTCCATCAACTTCAAATGAAGACAGTATAAAGGCATCTGAGGCAGAAcccgaagaaaaaagaaggcgaAGGACGTTGAGTAGTAGAACATCTTCAGAATCACCGAGTCTTCTATATAATAAGCGTAAAAAACGAAACGTTAATTACATAGATGACTTCAGCGACACAGATTCTGAAGAATCTTCATCGCCTTACTCCTTGcgtttcaaaaattcattacagagtcGAGGACCGACGCTACGTAGTCGCAGCAAACTTGGAAATTTCAGCTCTTTGGATGAAGGTGATGATGATATGgaactagaaaatatttcacgaatGGGTCTCAGAAGCAGTAGTTGCAGAAATTcatatttgaatgaaactgaTGACGAACCTCCTAGTCTGAGAACTAGGTCTCGGAGCAGAGCAGCTATGTCTTTTGAGTCTAATAAGAAAACTAATCAGTCTGTTGATTCAAATACTGTTGAGTTGTCAAGAACTAAAGCTAAAACTCCGATTCCaactgaaaattcaataaatcatgaaaaagaattacagtCAATTCAGAATATGTTATATGaacagcaaaaagaaaacgagCAAGAAGATGCTGAACTTGACAaggaaatggaaaatatttctcGTAATTATCCGTCGATTAGATCGCGCAGCAGAGAACCAAGTTATGAGCCGACAAAAACTCCAACCGAGGAACAAAGATTTCAGTCTGATGAAATTATCCGTAATAATTCTAtggaaaaatcaaatatttcacaaCTTAATGGTCTACAAACGCCAAGCGTGGGCAGGCTGCTTTCCACTCCAAAAACTGTTACtactaaaagtaaaactacAACTCCCTGTAGTGGAGCgtcaaaattgaaagaattattGAATACGCCAAGAAAAACTTCAAGCACTCTGTctcaaagtaaaaaacaaatttcaacaCCTACTAGCCAAAAAATTAGTAGTGCCGAACCTGTTCTAAATGGAGTCCTCAAGATAAAAAGTTCAGGGAAAGACAGtgcaaaaagtaatttgtttaataagtcCAAAACAGATTCAGGTGAATCGGATAAAATACACACAATGAATCTAAAACTAAAAAACCTTCAGgttcaattaataaagttgGAAACTGTATGTAGCAATGGTTTTAAGGATTATTCTGCCAGTGAGATAGAATTATTGACTAGAAAATATATTGACCTTCTAATGAATTCGAATTTCTCCTGCAACACGTGGCGTACTCCTATCAATTATCATAGAGTAACAGAAAATCATATTGAAGAAATTGATAATTCCGACTGCATATCAGATTCTGAAATGCAAATAGAAAACGAAAATACCATGAACATAGAAgaagttgaaaatattatttctactCCTGATATAATATCAGTTATGGAAAAGTATGTCACTTCTGCAGAGTCGGAAAAGGGTAGTCCAGAGAAATCTGGTGTAAGGCTGCAGGCTTATAATGCTTCTGTAACTTCTTTGGAAGCAGCAATTGCAACACTCGCAGATTCTGAATCTCAACATCAACAGAATATAAACGAAgacttaaatatttcagaagATAGTTCAAGACACGTAAATGATATCAGGGAGTTTAATTACGAAATACCTAGCACTGCAACCGAAAATGAAGGAGAAACTTCTGTTATAAAATCACATACAGTTCTTGTCAACGGCACATACATGTTAGTTTGCAGcctttgtaataaaatatttgcgaATCAACAAATGCTTGATGGTCACATTAGTGCTGATCACGCCACTTCTAAGGAAACTAGCGATTCTACGGTTTCCACAAATACATTGACTGCGAAGTCCAGCAAAACACAAGTTAATGATAATGCTTCTGAAGTGCCAGCTGGAAAGAAACAGCAATCAAAGAGTAAAAAGAAGGTCAAGACAGCTTCAAACAGCTTGCAGTGCACAATCTGCTCAGTAACGTTCGAAACTAGAGAATTGCTGTTTGAACACATAATGACTCATAATGAACAGGAATTGCAGGAAGCTTACAAAATCGCTGTAGCCAAGTCCAAGGAAACGCAGGCCGAATTAGCCAGAGCATCCAATGACGAACAAAGCGTTAGTAAGACCAAGAAAAATGCAAAGAGAAAAAGCACCGACAGCAATATACGCAGCAGTAGATCATCAATTGAAGGGGAGGATGGTAATGAGTCAACAATGGCTATGATTGGAGCTTCTGCATACCCAATAGACTATCCAATGgtACCTCATGTAGCGATTGGTAAGgataattctgtaaaaatatgtGGATGCCATGCGTACGAAACAACTGCTCAAGACCTCCAGATCGAAATGATACTTCTCTGCAAAGTATGCAATGTTGTATTCCGTCGACGCGAATGTTTCGAGGTGCATTTTCGTACTAGTCCCGAATGCCGCCGTAGACGGACCAACCTCGAGATCACCAAAATTCCCAAGCTCTTCTGCAGCGGATGTCCGTGTCTGCTGGACTCGCTCCTCGAAATGCGTGCACATCTCGAGATGCACGCGAGGAAAAACAGCCAGGGCACGGTCACCTTCATTTGCAACATCTGTAAGGTGGCTTTTTTCGGAGTCGGCGGCATCTTTTATTCACATTGGTTTAATCACACAAAAGCTCCGAATTTCGTGGCAAGCCGATTCTCCTTCCCGAAACTTTCGGTTGTTTCGGTATTGGAGGATTCATCTGTTGCTGTGACGACTTCCAAGAGTCAGGAAGGATTTTTCTACATAGCAGAACATGTTTGTCGAGAGTGCAGGTTACCGTTCAGTTCAGAACCTGAACTTCAAAAACACAAAATGGATCCCTGTCAGCCGCAACAGCCGGTCGTTCAGCGCCCCGAGATTCCAGAAAATAACCGTCTTCAAATGATAAAGCTAATATGCGATCTCTGCAAGAAATATTATGTCAGCAAAGATAACTTCGATCGTCATTGTTTAGAGCGCAACCATCTAAAGACTCCTATCACCAAGTTCTCGCGCCTACCCATCAACGCAAACGAACATGCATTCGTGTGCAGTTTGTGTCGTGCCATCAGCAAAACTTTGGATGAGATGAAAGAACACTGGAAGCGCATACACAGTCCTATAATAGAGCTGTACACCTGTAAGACTTGCAACATCGTACCGTCGCACGACATCGCTAACTACACAtacgaaaatttcgaaaaacaCTGCCGAGTATCACACAAGAGTGAGGTGATTACGTGTCTTGTTTACTTTGTCACTGCAAGATTCGTGTGCAATATCTGTAAATTCGGCTTCGAGAACGAGAAGTCCATGAAGGAGCACGAAACGATGCACCAGAGGTCGGGTCAGGCTCAATCTCCAATTTTTACGGTACCTCCATCAAACTCATTATCTATTACCATGCCAAACGCGGCACTGCCTCTACCAGTTCAACCGCAAACTGCAACTCTGTGGGTGGCTGACAAACATGTGGCTCCGGACGGAGGTAGACAAGTGCATCCCGTTTACGTGCACTATCCCGGTATCAATAATACGCAAACAAATATAgTGGAGCAAAATCCTCAAATTCAACAGCAGCAGGCGATGCAGACTCCACCTCAAATCCAAGTAAATACTACACCAAACTCTATCACTCCTGTGTACCAAATCAATTACGTTCCAGCAAACCAGAGCATTGTTCAAACAAATAATACCGTGATACTGCAGGGATTGCTGAATTCGTCAACACTGAATCAGCAATCGCAAAATACTCCAAATATAGAAACAATATTCCTTGACTCTAGATCTAATAGTCCTACGTCAGATGCACTTACTAGTACTGCAACTACAAGCAATGATACCAATGCAAACGATAATAACTCTGGTTCTGCTTCGAAAAAAGGATACATGACAATGGTAAATccagattttgaaaatatcttaaCGAATAGAATAGAAGAAAGCAACAAAAGCAAAACAACTCCGGCAAATGAAACAATAAGCGACACTGCAAGTGCAGATTCTTTTACTCCAGAACCGTTTGAAGTCGTCCTCCTGAATGACGATTTGAGTGAAAGCTCGAACAGCGAATCGACAGCACCGACGGATAAGGCTGCAAGTCCTAATATCAATGAGTCATCGTCGAATCAAGAGCAACCAGAGCAGAAAACAGAAAAAGGCGACAATTCTTCAATAAAACCATTTCTCCGTGTGCGTTCGATGGCTGAGCTTCAGGGTGTAAAGACGCACCTATGTCCTGTATGTGGACTGAGCTTTAATTCGTTGACAGCTTTCAATCAGCATACTACAATGGAGCACTCCCAGGCAGAGGCACAGCAAAATGAAGTTGGAAGAACGACACCAGTCCAAATGATTTCGCCGATGGTATCACAAACCAAGAAAACATCAATGAGTGAACCGCAAAATATAATCCTTTCAAACATCAGGCAAAAACTGGCTGTGCTCTCTACTCAAGCGTCATCGAccggaaataaGTCTAATTCAGTAGTTCAAACTAACCAGCCTCAAACTGAGCAAGGCCTTCAAATGCAACAGCCTCTAGTTCAACAGCAGCCACAATACCAGCAGCAGCCCCAATACCACCACCAGCAGCAGCCACAATACCAGCAGCAGCCACAACAACAGCAGCCATACTTATTTGCTTCTTGTAATAGTGCGAATAATCCTGCTTCATCGAACGTTAATAACGCTCCTCCTTTGATTCGGGCAAATATCCTTCGTCGCAACCCGGGTACCACAGCGACAAATGTAGACGGCAATTATTCGGTGCTACGTGGACCACCACCACCGTATCCTAGTTCGTCTAATTCCACCGTTTCTAATAGGCCAGGCGCTATTCAGCTGCCCGAGAGAAACATCGTAATTGGGGGCGCGCCAGCAACGAAAAGACCCTCCGGTGCAGCGACTCGAATACCTCAGCAGAGTCTGCCGAGTTTCGAGGAGATCACTGACCGAAGACAACCTgGAATTCGAATACCGCTGAATCCAGCTGATGATGTAAACTCCAACCTACCTACAAACGCGCCCCGAGTCCTTCCAAGTCTGAGAGCACCAACGCATCAACAGTCTACCCATCAATTCCAAGGAAAAACTTATTCCCGTAACTCGAGCAATGTTCAGTATTCTGGTTCGGTCAATAACACGCCAACACTCCAAAATTTACTGCAACCTCAACCGCAGCAGCATCACCaccagcagcaacaacaacacccacagcagcagcaacaattACATCAGCAGCCACAACAGCAGCAATCAGTAAAGTACATGTATAACTGTAAAAGCTGCCCATTTCGTGCAGATAGTATTGGTGTTATCCGTGTTCATGAAAGGATTCACTTACCTTCCACTGCAAACGTTAATCAAGTGAACCAAGTGTCTCAGCAGCAACAGCCGCAACAACAACGATTTGGTGCAAAGCACGTGTCGGTAACCACGATGCCCGAAAGAACACGAAATGCAGTACCGAATGTTCGTCAGGCTTCCGTTAATCCAGATAAACGTTACGTGTGTCGTATTTGTCATCAAATTTATACGACGGACTCTGCGTTGGTGGAACACGTATCCACGGTTCATAGTGACCCTGCGCCTAGATTGTGTTGCTACATATGTGATTACTGCGCCCAACCGTTAATATTCGAATCCGAGGAGCTACTACGGAAGCATATGGATTCCGCTCATAATTACTCTTGTGACATTTGTCATAAAAGATACCCATCACGCCCAGAGCTTATGATACACATGGAGGTACATAGTCGAAACACTTGA
Protein Sequence
MSDDDASQCQRTQPFAGNCSRTKPYLKSVKTKVSNASETSTNSINDEISLEIVSDPVISNEIDKGRQDISDKDQDIPVNEENEIVEPVTDVTSAALPSSKKAKTKTSCESKASADKTIPTTAVSPGKTICSLLSLNCKKHDHHHHNHQQEQQSIINFNLKQDAYVLLDRLELMTDPLVLNYLKKTDRISKIKEDPSPKKNKNNLNESDKSSVHKNQKQDVAHSNNEESTAKDDTPKLNKEEKLIEANLKDHCAATVKEISEIIPSTSNEDSIKASEAEPEEKRRRRTLSSRTSSESPSLLYNKRKKRNVNYIDDFSDTDSEESSSPYSLRFKNSLQSRGPTLRSRSKLGNFSSLDEGDDDMELENISRMGLRSSSCRNSYLNETDDEPPSLRTRSRSRAAMSFESNKKTNQSVDSNTVELSRTKAKTPIPTENSINHEKELQSIQNMLYEQQKENEQEDAELDKEMENISRNYPSIRSRSREPSYEPTKTPTEEQRFQSDEIIRNNSMEKSNISQLNGLQTPSVGRLLSTPKTVTTKSKTTTPCSGASKLKELLNTPRKTSSTLSQSKKQISTPTSQKISSAEPVLNGVLKIKSSGKDSAKSNLFNKSKTDSGESDKIHTMNLKLKNLQVQLIKLETVCSNGFKDYSASEIELLTRKYIDLLMNSNFSCNTWRTPINYHRVTENHIEEIDNSDCISDSEMQIENENTMNIEEVENIISTPDIISVMEKYVTSAESEKGSPEKSGVRLQAYNASVTSLEAAIATLADSESQHQQNINEDLNISEDSSRHVNDIREFNYEIPSTATENEGETSVIKSHTVLVNGTYMLVCSLCNKIFANQQMLDGHISADHATSKETSDSTVSTNTLTAKSSKTQVNDNASEVPAGKKQQSKSKKKVKTASNSLQCTICSVTFETRELLFEHIMTHNEQELQEAYKIAVAKSKETQAELARASNDEQSVSKTKKNAKRKSTDSNIRSSRSSIEGEDGNESTMAMIGASAYPIDYPMVPHVAIGKDNSVKICGCHAYETTAQDLQIEMILLCKVCNVVFRRRECFEVHFRTSPECRRRRTNLEITKIPKLFCSGCPCLLDSLLEMRAHLEMHARKNSQGTVTFICNICKVAFFGVGGIFYSHWFNHTKAPNFVASRFSFPKLSVVSVLEDSSVAVTTSKSQEGFFYIAEHVCRECRLPFSSEPELQKHKMDPCQPQQPVVQRPEIPENNRLQMIKLICDLCKKYYVSKDNFDRHCLERNHLKTPITKFSRLPINANEHAFVCSLCRAISKTLDEMKEHWKRIHSPIIELYTCKTCNIVPSHDIANYTYENFEKHCRVSHKSEVITCLVYFVTARFVCNICKFGFENEKSMKEHETMHQRSGQAQSPIFTVPPSNSLSITMPNAALPLPVQPQTATLWVADKHVAPDGGRQVHPVYVHYPGINNTQTNIVEQNPQIQQQQAMQTPPQIQVNTTPNSITPVYQINYVPANQSIVQTNNTVILQGLLNSSTLNQQSQNTPNIETIFLDSRSNSPTSDALTSTATTSNDTNANDNNSGSASKKGYMTMVNPDFENILTNRIEESNKSKTTPANETISDTASADSFTPEPFEVVLLNDDLSESSNSESTAPTDKAASPNINESSSNQEQPEQKTEKGDNSSIKPFLRVRSMAELQGVKTHLCPVCGLSFNSLTAFNQHTTMEHSQAEAQQNEVGRTTPVQMISPMVSQTKKTSMSEPQNIILSNIRQKLAVLSTQASSTGNKSNSVVQTNQPQTEQGLQMQQPLVQQQPQYQQQPQYHHQQQPQYQQQPQQQQPYLFASCNSANNPASSNVNNAPPLIRANILRRNPGTTATNVDGNYSVLRGPPPPYPSSSNSTVSNRPGAIQLPERNIVIGGAPATKRPSGAATRIPQQSLPSFEEITDRRQPGIRIPLNPADDVNSNLPTNAPRVLPSLRAPTHQQSTHQFQGKTYSRNSSNVQYSGSVNNTPTLQNLLQPQPQQHHHQQQQQHPQQQQQLHQQPQQQQSVKYMYNCKSCPFRADSIGVIRVHERIHLPSTANVNQVNQVSQQQQPQQQRFGAKHVSVTTMPERTRNAVPNVRQASVNPDKRYVCRICHQIYTTDSALVEHVSTVHSDPAPRLCCYICDYCAQPLIFESEELLRKHMDSAHNYSCDICHKRYPSRPELMIHMEVHSRNT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00713935;
90% Identity
-
80% Identity
-