Basic Information

Gene Symbol
gtf3a
Assembly
GCA_900475205.1
Location
UXGB01000346.1:20923-24111[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0017 0.2 12.9 1.5 1 23 227 249 227 249 0.97
2 17 2.7 3.2e+02 2.8 3.0 1 19 255 273 255 274 0.89
3 17 3.1 3.6e+02 2.6 1.0 3 23 283 303 282 303 0.97
4 17 0.037 4.3 8.7 1.9 3 23 312 333 311 333 0.96
5 17 0.0033 0.39 12.0 1.3 1 23 340 363 340 363 0.95
6 17 0.00028 0.033 15.4 1.2 1 23 369 392 369 392 0.94
7 17 4.2 4.9e+02 2.2 1.5 2 23 400 420 399 420 0.90
8 17 3.1e-07 3.6e-05 24.7 3.0 2 23 426 447 425 447 0.97
9 17 2.9e-06 0.00034 21.6 0.2 1 23 453 475 453 475 0.99
10 17 0.00063 0.074 14.2 3.1 2 23 487 509 486 509 0.95
11 17 0.017 1.9 9.8 2.3 1 23 515 538 515 538 0.95
12 17 0.014 1.7 10.0 2.8 2 23 560 582 559 582 0.93
13 17 0.00078 0.092 13.9 0.7 2 23 589 611 588 611 0.96
14 17 3.5e-05 0.0041 18.2 1.6 2 23 619 640 618 640 0.96
15 17 0.0081 0.95 10.7 2.4 1 23 646 669 646 669 0.94
16 17 0.86 1e+02 4.4 4.1 2 23 676 697 675 697 0.96
17 17 0.0029 0.35 12.1 2.7 1 23 703 725 703 725 0.98

Sequence Information

Coding Sequence
ATGCttttgataaaagtaaaaaagatgGATAAAtcatctgaaaagaaaggggATAAAgttggaaagaaaaaagagtcTACAGTAATGCACAGAATATTTCCAAAGTATGATGGAAATAGCAGTAAGGGTAGCATAATCGACGAACAgatagaagtatataaaaagaaaagagtagAAATATTAGGTGAATCAGCTATTGTTTCAGAGATGGAGATGGAAGTGGAAGAGCCGGAAATTAGAGCAGCAGGAGGACTTGAAgtaacaaatgaaaaagatgaaaaagagcaaaaaaatgaattagaagatgattctaaaaaagtattacatgTAGAAGGTTCATTAGATGGTAATAAATTGTCTATTTCTGCATTAGAGCAGCCTTCAAATCTTGATAAGCTAAAGCAACGCTggaaagatattaaaaaaacccaCGACACTATTACTAAAGATTTATCAGAAGATTGTTCTGCCAGATTACGAGCACTTCTCAAACAAAAGGATGAATATATAGCAGAATTTGTTAGCTATTTAAAGCAGAGAAGAATTGTAGTATCGCGTCTCAAAGACGAAGATATTATTAcattgtatgaaaaaaaaaataatgtaattatagaGAGACCTTCTGCAACAATTAAAGAGGAGGTGCAAGAAATAGATCCATTTGCATGCTTAAAAAGTTATGAGTGCGATTTCTGTTTCAAATCATTTCCGGACAGAGATGAGATGTTTGAGCACTCGAAGTACCACGATTTTAGAATAATGCACTATTGCGAAGATTGTaagcaagaattttttacccaCAAAGCCAAACGCGCTCACAATCCCGACTGTTTACAAAAACTGCTATGCAGGTACTGCGATGTGATGTTAGAATctaaaggaaagaaaagacaACACGAGCAGAAGCACTGCGACGACGAGCACGGCCAGTTATGCGATAAGTGTGGTGATAAATTCAAACATCAAGGTACCTTAGATCAACATGTGAAATTGCGACACATGcagttggaaaaaattttcaaatgtccGCAATGTCCGAAAAGATTTGCTTTAAGACAGAAGCTGACCTTTCACTTAAAATCTGTGCACACCACCAGTAGACCTTTCCTCTGCGAAGATTGCGGATCGGACTTCAAAAACCCTGCAAGCTTAAGGCACCACAGAATACGAAAGCACCAGCCGACAAATAGCAAAAAGGAATGTACGGTCTGTCAGAAGATGATTCCAGTCTATAGTATGTCGAAGCACATGCACACGCACAAATCGTACTCTATCAAATGTCCTCACTGTGacaaaatgttcaaaaacaCCTCGACCTTGAAGCAGCACCTACGAATCCACGAGGATCAAAGGCAGTACAAGTGCGACATGTGCGGTGTCGGTTTCAACAGGCGTGACGGTCTGAGGCTGCATCTACGGGTCCACGAGAAGACCGACAGTCGAGGCCTAAAGGAGTGCTCGTGCCAGGTCTGCGGCGAGAAGTTCCCCAACCACTCGACCCTCGTCATCCACCGAAACCGTACACACAAGGACGGACGCAACTATACGTGCCACATATGCAACAGATCGATGATATCCACGCGTTCGCTCGAGTGGCACTTGTCGCATATCCACAACGAGCCGCTGCCAGGCCTCGTAAAGGACGAATCGAGCATCGACGCCGAGACGAAGCGCGTCTCCTGCTTCCACTGCGACAAGACCTTCAAGACCGAGATGATTCTGCGGACGCACGTGAAGAACACGCACACGCAGAAGGAGCCGATAAAGTGCCTGGACTGCGAGTTGATGTTCACGTCGGAGGTGAGACTGAAGCACCACATGATGGTGGAGCACAACCGGTTAGAGGGCACTCTCTCTTGTCCTCACTGTCCTAAACGCTTCGTCAACCAACTGAGACTAAAGACGCACATGATCTCGCACTCGGACGAGCGGCCGCACTCCTGCGACCTGTGCGGTTTCATGCTCAAGACGAAGATACAGCTGATCAAGCACAAGCAGAACAGACACAGCAACGAGAGACCGCTGCAGTGTAGGTACTGCTCCTGGCGGTGCAAACAGGTGAGCGCGCTCGTTTGTCACGAGAGGACACACACGAACGAGCGGCCCTACAGCTGCAGCGTCTGCAAGCAAAGATTCAAGTACCTGGGCGACAAGAACAAACACGAGAGACGGCATGAAAGCCTCGGGGGCAGCGGTTTCAAGAGAATCGTCACTGGTAGAAACACAAACAAAAGTATCAAGAGGAGGGAGGAAGGCAACTCGACGGAGATGGATTCGGAAATTGAGCGCGAAGCGTACAACAAAGAAGAAGAGGTTGAAGGGCAGATCGAGCAGGATGAGATCGAAACTTTTGACGaaacaaaaattgtcaaattCGATACTGATGAAATGGTTGCACAAAGTTCAGAAGACTTTCACCAGatTTACGTGCAGGAAGTCACGCAAGATATGGACACTACAACTGAAGTTGTAGTGGGTGTGGAAGAAACGTCCGTTTACACCGAAGAAGTTACCGCAGGTTACTCTAAGCAGGGTGTGATAGCCGGCATAATAGATGAACAAATGTTACAACCCGGTACGGTTGTTCATCTCGAACAGGAAGATGAAAACGGAAAAATTCAAGTGATACCCGTGATGCTGTCCCTCCCAGATTTAACGGATGGTACATCTGAAGTAAATTTAGCAACGGCATCAATAATGTATAGTACCTAG
Protein Sequence
MLLIKVKKMDKSSEKKGDKVGKKKESTVMHRIFPKYDGNSSKGSIIDEQIEVYKKKRVEILGESAIVSEMEMEVEEPEIRAAGGLEVTNEKDEKEQKNELEDDSKKVLHVEGSLDGNKLSISALEQPSNLDKLKQRWKDIKKTHDTITKDLSEDCSARLRALLKQKDEYIAEFVSYLKQRRIVVSRLKDEDIITLYEKKNNVIIERPSATIKEEVQEIDPFACLKSYECDFCFKSFPDRDEMFEHSKYHDFRIMHYCEDCKQEFFTHKAKRAHNPDCLQKLLCRYCDVMLESKGKKRQHEQKHCDDEHGQLCDKCGDKFKHQGTLDQHVKLRHMQLEKIFKCPQCPKRFALRQKLTFHLKSVHTTSRPFLCEDCGSDFKNPASLRHHRIRKHQPTNSKKECTVCQKMIPVYSMSKHMHTHKSYSIKCPHCDKMFKNTSTLKQHLRIHEDQRQYKCDMCGVGFNRRDGLRLHLRVHEKTDSRGLKECSCQVCGEKFPNHSTLVIHRNRTHKDGRNYTCHICNRSMISTRSLEWHLSHIHNEPLPGLVKDESSIDAETKRVSCFHCDKTFKTEMILRTHVKNTHTQKEPIKCLDCELMFTSEVRLKHHMMVEHNRLEGTLSCPHCPKRFVNQLRLKTHMISHSDERPHSCDLCGFMLKTKIQLIKHKQNRHSNERPLQCRYCSWRCKQVSALVCHERTHTNERPYSCSVCKQRFKYLGDKNKHERRHESLGGSGFKRIVTGRNTNKSIKRREEGNSTEMDSEIEREAYNKEEEVEGQIEQDEIETFDETKIVKFDTDEMVAQSSEDFHQIYVQEVTQDMDTTTEVVVGVEETSVYTEEVTAGYSKQGVIAGIIDEQMLQPGTVVHLEQEDENGKIQVIPVMLSLPDLTDGTSEVNLATASIMYST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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