Eocc034746.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Eurois occulta
Gene Symbol
Ets97D
Assembly
GCA_950022335.1
Location
OX465505.1:2589301-2602961[+]

Transcription Factor Domain

TF Family
ETS
Domain
Ets domain
PFAM
PF00178
TF Group
Helix-turn-helix
Description
Transcription factors are protein molecules that bind to specific DNA sequences in the genome, resulting in the induction or inhibition of gene transcription [3]. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [3, 5, 4]. This domain is rich in positively-charged and aromatic residues, and binds to purine-rich segments of DNA. The ETS domain has been identified in other transcription factors such as PU.1, human erg, human elf-1, human elk-1, GA binding protein, and a number of others [3, 5, 2]. It is generally localized at the C terminus of the protein, with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found at the N terminus. NMR-analysis of the structure of the Ets domains revealed that it contains three α-helices (1-3) and four-stranded β-sheets (1-4) arranged in the order α1-β1-β2-α2-α3-β3-β4 forming a winged helix-turn-helix (wHTH) topology [1]. The third α-helix is responsive to contact to the major groove of the DNA. Different members of the Ets family proteins display distinct DNA binding specificities. The Ets domains and the flanking amino acid sequences of the proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificities.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 45 5.9e-32 2.4e-28 99.4 0.2 1 79 341 418 341 420 0.96
2 45 5.1e-12 2.1e-08 35.5 0.8 44 79 419 454 417 456 0.92
3 45 5.4e-12 2.2e-08 35.4 0.8 44 79 455 490 453 492 0.92
4 45 5.4e-12 2.2e-08 35.4 0.8 44 79 491 526 489 528 0.92
5 45 5.3e-12 2.2e-08 35.5 0.8 44 79 527 562 525 564 0.92
6 45 5.1e-12 2.1e-08 35.5 0.8 44 79 563 598 561 600 0.92
7 45 5.1e-12 2.1e-08 35.5 0.8 44 79 599 634 597 636 0.92
8 45 5.2e-12 2.1e-08 35.5 0.8 44 79 635 670 633 672 0.92
9 45 5.4e-12 2.2e-08 35.4 0.8 44 79 671 706 669 708 0.92
10 45 5.5e-12 2.3e-08 35.4 0.9 44 79 707 742 705 744 0.92
11 45 5.4e-12 2.2e-08 35.4 0.8 44 79 743 778 741 780 0.92
12 45 5.3e-12 2.2e-08 35.5 0.8 44 79 779 814 777 816 0.92
13 45 5.1e-12 2.1e-08 35.5 0.8 44 79 815 850 813 852 0.92
14 45 5.2e-12 2.1e-08 35.5 0.8 44 79 851 886 849 888 0.92
15 45 5.1e-12 2.1e-08 35.5 0.8 44 79 887 922 885 924 0.92
16 45 5.1e-12 2.1e-08 35.5 0.8 44 79 923 958 921 960 0.92
17 45 5.3e-12 2.2e-08 35.5 0.8 44 79 959 994 957 996 0.92
18 45 5.4e-12 2.2e-08 35.4 0.8 44 79 995 1030 993 1032 0.92
19 45 5.2e-12 2.2e-08 35.5 0.8 44 79 1031 1066 1029 1068 0.92
20 45 5.3e-12 2.2e-08 35.5 0.8 44 79 1067 1102 1065 1104 0.92
21 45 5.1e-12 2.1e-08 35.5 0.8 44 79 1103 1138 1101 1140 0.92
22 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1139 1174 1137 1176 0.92
23 45 5.5e-12 2.3e-08 35.4 0.9 44 79 1175 1210 1173 1212 0.92
24 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1211 1246 1209 1248 0.92
25 45 4.8e-12 2e-08 35.6 0.7 44 79 1247 1282 1244 1284 0.92
26 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1283 1318 1281 1320 0.92
27 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1319 1354 1317 1356 0.92
28 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1355 1390 1353 1392 0.92
29 45 5.2e-12 2.1e-08 35.5 0.8 44 79 1391 1426 1389 1428 0.92
30 45 5.2e-12 2.1e-08 35.5 0.8 44 79 1427 1462 1425 1464 0.92
31 45 5.3e-12 2.2e-08 35.5 0.8 44 79 1463 1498 1461 1500 0.92
32 45 5.2e-12 2.1e-08 35.5 0.8 44 79 1499 1534 1497 1536 0.92
33 45 5.2e-12 2.1e-08 35.5 0.8 44 79 1535 1570 1533 1572 0.92
34 45 5.2e-12 2.2e-08 35.5 0.8 44 79 1571 1606 1569 1608 0.92
35 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1607 1642 1605 1644 0.92
36 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1643 1678 1641 1680 0.92
37 45 5.4e-12 2.2e-08 35.4 0.8 44 79 1679 1714 1677 1716 0.92
38 45 5.3e-12 2.2e-08 35.5 0.8 44 79 1715 1750 1713 1752 0.92
39 45 5.3e-12 2.2e-08 35.5 0.8 44 79 1751 1786 1749 1788 0.92
40 45 5.5e-12 2.3e-08 35.4 0.9 44 79 1787 1822 1785 1824 0.92
41 45 4.9e-12 2e-08 35.6 0.7 44 79 1823 1858 1820 1860 0.92
42 45 5.3e-12 2.2e-08 35.5 0.8 44 79 1859 1894 1857 1896 0.92
43 45 5.5e-12 2.2e-08 35.4 0.9 44 79 1895 1930 1893 1932 0.92
44 45 5.3e-12 2.2e-08 35.5 0.8 44 79 1931 1966 1929 1968 0.92
45 45 1.2e-14 4.9e-11 43.9 0.7 44 81 1967 2004 1965 2004 0.96

Sequence Information

Coding Sequence
ATGGAGGTGACAGACTTAAACGATCTGCTGAATGTTCGGTCGATCAAAATGGAGCAAGGGGAAACTGGATTTGACGAAAACACTGTGGAAACATCTGACCCTCTATCTATTATACCTCAATATGTGACCGAGTCTGATTTAGGTCTCATGCAGACTGGAGGTGAGATACTGCAGACGCCGCTAGCAGTGTTCTCTGACACTCCTGATGAAGACGACACCATGCAGAGCACGGAGAGCAGTGATGAGGTGATTGTCCAGCTCATGGATATCAGGACCAATCTGTCTCGTCTCAGAGCGATGCTAGAGAGAAGACTGGGTTTGGATCTCTCAGATTACACATTCTGGCTGCAAAACGCAAAAATGCTGGAGAACCACAAGACTCTAGTAGAACAGTGCATACGGGGAGAAGGAGTGGTGCAGGTCAACATCCAAATACGCTCCTCGGAGAGGAAGATCAATATCTTGGATGTGTTGAAACCTGATGAGGAGTTGGTTCAGCTGCCTAATCAGATGGATGATGAATTGCTGGAGCTGGCGGAGCCACTGGGCGCGCCAGCCACGCGCACCGGGCAGGACGTGGTGTCGCACGCGGCGGCCGTCAAGTGGGTCGTGGACGCGCAGTTCAAGAGCGAGCACCGCGTGCGCGTGCCCGACGACCCCGCGCTCTGGTCGGTGCAGCACGTGAAGCTGTGGATACAGTGGGCGGTGCGCCAGTTCAACTTGACCGGCATCAAGCTGTCCGACTGGAACATGAGCGGGGAGGAGCTTTGTACGCTCAACAATGAGGATTTCAAAGAAAAAGTACCTTCTGACCCGGGAGACATATTCTGGACACATTTCGAGTTGCTAAGAAAGTGCAAATTTATTGCCGTGATTCAGACCGACGAGCAGCCAGTCAAGGATCCTCTCGAAGTCCCGCAGTCAGCTATTAAGAAGAAGCCTAAACAGGTGGTGATCCGGCCGACGGAGGACGACTGGTCGACATACGTGACGTCACGCAACGGGAACAACGGACAGATCCAACTGTGGCAGTTCCTGCTCGAGCTGCTCACCAGCGCCGAGTACTTCGAGGTCATCCGGTGGCACGGCACGGAAGGCGAGTTCAAGCTGCTGGAGCCGGAGCGCGTGGCGCGGCTGTGGGGAGCGCGCAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTACGTACACTCGTACAAGCACAAGCCCGCCATGAACTACGAGAAGCTCAGCCGCGCGCTGCGCTACTACTACGACGGCGACATGATCGCCAAGGTGTCCGGCAAGAGGTTCGTGTACAAGTTCGTGTGCGACCTGCGCCAGCTGCTGGGCTACGGCGCTGGCGAGCTCGCCGAGCTGGTGAAGGAGGTGCACGACGGCAGACCCATCATCAAGTCCATAGACGACGTCAAGAAGATCGTCTTCTAA
Protein Sequence
MEVTDLNDLLNVRSIKMEQGETGFDENTVETSDPLSIIPQYVTESDLGLMQTGGEILQTPLAVFSDTPDEDDTMQSTESSDEVIVQLMDIRTNLSRLRAMLERRLGLDLSDYTFWLQNAKMLENHKTLVEQCIRGEGVVQVNIQIRSSERKINILDVLKPDEELVQLPNQMDDELLELAEPLGAPATRTGQDVVSHAAAVKWVVDAQFKSEHRVRVPDDPALWSVQHVKLWIQWAVRQFNLTGIKLSDWNMSGEELCTLNNEDFKEKVPSDPGDIFWTHFELLRKCKFIAVIQTDEQPVKDPLEVPQSAIKKKPKQVVIRPTEDDWSTYVTSRNGNNGQIQLWQFLLELLTSAEYFEVIRWHGTEGEFKLLEPERVARLWGARKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRYVHSYKHKPAMNYEKLSRALRYYYDGDMIAKVSGKRFVYKFVCDLRQLLGYGAGELAELVKEVHDGRPIIKSIDDVKKIVF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-