Basic Information

Gene Symbol
-
Assembly
GCA_018238005.1
Location
DWAJ01004832.1:4487-5851[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00012 0.01 16.8 1.9 1 23 97 120 97 120 0.95
2 10 8.1e-05 0.0071 17.3 3.9 3 23 129 150 128 150 0.96
3 10 0.51 45 5.4 6.4 2 23 158 180 157 180 0.95
4 10 2e-05 0.0018 19.2 0.7 2 23 188 210 187 210 0.92
5 10 0.011 0.94 10.7 8.2 1 23 217 240 217 240 0.93
6 10 0.0062 0.54 11.4 6.3 1 23 246 269 246 269 0.94
7 10 4.2e-05 0.0037 18.2 0.3 2 23 277 298 276 298 0.97
8 10 0.0011 0.094 13.8 2.2 2 23 306 328 305 328 0.96
9 10 8.7e-05 0.0076 17.3 3.4 2 23 335 357 334 357 0.94
10 10 3.7e-05 0.0032 18.4 3.9 1 23 367 389 367 389 0.97

Sequence Information

Coding Sequence
ATGACGGATCAAATGCCAATCTACGAGCAACAAGAAGGCGCCTCCTTCCCACCGTACACAGGCCTAAAGATGGAGGAGCAGCCATATCCTTCCATGGAGCCTGGGTACAGCGAAAACATGGCGCAAACCTTCGAACCTCCTGTAGAACCGAAAATAGAACCGGAACCAGGAAAGCCAATACGATTCATATCAGTCAACAGCACCCAGCTGACTGAAGAGCAAAGAGCTATGTACGAGTCAGTCCTCACCACCTGGAAACCTGTCCTCTTCCCGAAGCAAATGAAGAGGTACATATGCGAAAAGTGCAATAAAGAATTCAAGAATTACCAAAACCTATACCTGCATACCACGAGGGTGCACTCGTCGGAAGAATCGGCGGTTCTCTGCAACATTTGCGACAAGTCATTCAAGAATAAACATTACCTGTACATGCATAGGATGAATAAGCACTATTCGGAGTCCGAGAAGTGCTACTGCCAGTTCTGTCTGCAAGAGTTTAGGACCAGGCGCGCGTTGCATATGCACGTTAAGAGGTTCCACCCAAATACTCTGCCTGAGCTGAAGTGTCCCGAATGTGGGAAGGAGTTCAGAGTTCCCTATAAGCTTCGCTACCATATCGACGCCTGCCACAGGCCAGATAAAGACAAATACAAATGCCATATTTGCCAGAAATTATACAAAAGCCACTTAAACTTGAACAGACACCTGCATTTCCAGCACTCCCAAGTGGAGAGACACCCCTGCGTGTTCTGCAGTATGACGTTTAAATCTCGCCATCATATGAAGCGTCACATCCTGAACATTCACCCTCCATTAGAGTCCAAAGTCCAATGCCCCGAGTGTCTGAAAGAGTTCAAGAACGACCAATATCTCAAAGAGCATATGCAAGTGCACTCGTCACTCGATACGAAAGTGAAGTGCGATCTGTGTGACAAGTTCTTCCATTCAGCGGTTCGTTTGAAGAAGCATAAGAAGATCGTGCATCCGGATAAACCCAAACTTCGCTGCGAAAAGTGTGACAAGGAGTTTGCGCACGCGCACTACTTGAGGCGCCATAACAACTCGGTTCATATGGAAGTAGATGAGAGCCAGTATGAGCATGAGTGCGACCAATGCGGGAAGAAGTTCAAAATCAAGAGATACCTGAACAACCACTTACAAAGGCACGAGCAGCAACATCTAAAGCGTATCTCGCAGATGGTGAAGACGGTGATGGATGATGGGCAAGAGAAGGTGGTCAAGAAGAGAGGCAGGCCTCGCGGCAAGCAGACGAAGACAAGGAAAGAGATAGAGTTCGTCAAGTGCGAGCCCATGTCGTCCGAGGAGGAGTCGGAAGAAGAGActggcgagtccgactcgGAATAG
Protein Sequence
MTDQMPIYEQQEGASFPPYTGLKMEEQPYPSMEPGYSENMAQTFEPPVEPKIEPEPGKPIRFISVNSTQLTEEQRAMYESVLTTWKPVLFPKQMKRYICEKCNKEFKNYQNLYLHTTRVHSSEESAVLCNICDKSFKNKHYLYMHRMNKHYSESEKCYCQFCLQEFRTRRALHMHVKRFHPNTLPELKCPECGKEFRVPYKLRYHIDACHRPDKDKYKCHICQKLYKSHLNLNRHLHFQHSQVERHPCVFCSMTFKSRHHMKRHILNIHPPLESKVQCPECLKEFKNDQYLKEHMQVHSSLDTKVKCDLCDKFFHSAVRLKKHKKIVHPDKPKLRCEKCDKEFAHAHYLRRHNNSVHMEVDESQYEHECDQCGKKFKIKRYLNNHLQRHEQQHLKRISQMVKTVMDDGQEKVVKKRGRPRGKQTKTRKEIEFVKCEPMSSEEESEEETGESDSE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00943106;
90% Identity
iTF_00710462; iTF_00710463;
80% Identity
iTF_00710462; iTF_00710463;