Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 2.1e-05 0.0021 19.4 1.4 1 23 183 206 183 206 0.97

2 4 0.00076 0.076 14.4 0.8 1 23 212 234 212 234 0.96

3 4 8.3e-08 8.3e-06 26.9 1.7 1 23 240 262 240 262 0.98

4 4 1.1e-05 0.0011 20.2 4.3 1 23 268 290 268 290 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	2.1e-05	0.0021	19.4	1.4	1	23	183	206	183	206	0.97
2	4	0.00076	0.076	14.4	0.8	1	23	212	234	212	234	0.96
3	4	8.3e-08	8.3e-06	26.9	1.7	1	23	240	262	240	262	0.98
4	4	1.1e-05	0.0011	20.2	4.3	1	23	268	290	268	290	0.97

Coding Sequence: ATGAAAGTCAATTTGTTGCAGCGACATGATACGGCCCATTTCGTTCAAGCGACAAATGAAATCAAGTTTGGAATCAACCGCTTAGTAAGCGATAGAACCGAAGAGGAAGAAGAGGATAATTATCAAGAGCCAATACAAGAAAATGTCTCTCCCACATCACGCTGCGGTAGTCCGTGCTGGGTGGCATCACCACAATCCCCTAGATCTGTACGATCCTCTTCACCTGAACTCGAAGTGGATTCACCTCCATTGTCTCCGAGAAGGCTACCAGATACTCCACCTCCACCAAAAAGATCAGAAGCTTTCTCCGTCAGCGCTTTATTGAAACCTGATGCTCCGAGAATTCAACCACAAAGACCTTTGTTGTATCCAGAATTACCATTTGCGAATATTCTTAGAGATGCAAGAAGTTTGGCAATCCCAGGATGGCCTAGTTATAGCCATTTTTACCTTCATGCTATGCAAGCAGCAGGCCCTGATCTAATTAGGGCTGCAGTATTAGGAGCACCTGGATCGTTCCCGAGATCTTTGCCTGTTGGCGATGTATACTCGTGTGTTAAATGTGAAAAAATGTTTAGTACTCCGCATGGTTTAGAAGTTCATTCCAGAAGATCCCATAACGGGAAAAGACCATTTGCATGTGAACAATGTAGCAAAACCTTTGGACACGAAATTAGCCTCAGTCAGCACAGGGCCGTCCACAGTGTGGAGAAAGTGTTTGAATGCAAGCAATGCGGAAAGACTTTTAAGAGATCCAGTACACTTTCCACTCACCTGCTCATCCACTCCGACACCAGGCCGTATCCATGCCAGTATTGCGGCAAACGGTTTCACCAGAAATCAGACATGAAGAAAcacacttacatacatacagTGAGTGTGAAAGAGATGACAACTATGTTGATATTCAGAGTGAAAGAGATGAAGAAGAAGGGCTGGGTTAGTTATTGGGCACATGTTTTTGTTAAATGA
Protein Sequence: MKVNLLQRHDTAHFVQATNEIKFGINRLVSDRTEEEEEDNYQEPIQENVSPTSRCGSPCWVASPQSPRSVRSSSPELEVDSPPLSPRRLPDTPPPPKRSEAFSVSALLKPDAPRIQPQRPLLYPELPFANILRDARSLAIPGWPSYSHFYLHAMQAAGPDLIRAAVLGAPGSFPRSLPVGDVYSCVKCEKMFSTPHGLEVHSRRSHNGKRPFACEQCSKTFGHEISLSQHRAVHSVEKVFECKQCGKTFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTVSVKEMTTMLIFRVKEMKKKGWVSYWAHVFVK*

Sequence clustering based on sequence similarity using MMseqs2