Basic Information

Gene Symbol
Zfy2
Assembly
None
Location
GWHALOE00000055:706243-708542[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 3.2e-06 0.00023 20.9 0.3 2 23 28 49 27 49 0.96
2 14 1.4e-06 0.0001 22.0 0.6 1 23 55 78 55 78 0.96
3 14 0.00022 0.016 15.1 1.6 1 23 84 106 84 106 0.98
4 14 7e-06 0.0005 19.8 0.7 1 23 112 134 112 134 0.97
5 14 0.01 0.76 9.8 4.6 1 23 140 162 140 162 0.94
6 14 2.1e-05 0.0015 18.3 2.7 1 23 168 190 168 190 0.98
7 14 0.079 5.7 7.1 1.6 1 21 196 216 196 217 0.93
8 14 0.00037 0.027 14.4 1.0 1 23 299 321 299 321 0.98
9 14 3.8e-07 2.8e-05 23.8 0.7 1 23 327 350 327 350 0.96
10 14 0.0064 0.46 10.5 0.5 1 23 356 378 356 378 0.98
11 14 3.7e-06 0.00027 20.7 3.1 1 23 384 406 384 406 0.96
12 14 7.2e-06 0.00052 19.8 0.8 1 23 412 434 412 434 0.98
13 14 1.9e-06 0.00014 21.6 0.9 1 23 440 462 440 462 0.98
14 14 1.7e-05 0.0013 18.6 3.8 1 23 468 491 468 491 0.96

Sequence Information

Coding Sequence
ATGAGCAATAGTTTAAAAAAGTATAATAGAAAATGCAACAAAAAAGGTGTCAATAGTCAGAAAAATCCTAGTGATTTTCTCATGTGTGGTGATTGTGGAAGATTATTCAAAGTGAAGGACTCATTGATGCGCCACTTGCGTATACATAGAGATGAGCGTCCCTTTACTTGCCATGTATGCGGAAAACAGTTTCGTGATTCTGGAGGTTTGGGTAGACATATCAAAGACGTTCATGCGGGATTAAAAAATCATAAATGCGAAATATGTAGCAGAAGCTTCGCATCTAAAGCCACTAGAGATGATCATCAGCGAATTCACACAGGTGAAAGACCTTACATTTGCGATACCTGTGGTAAAGGTTTTAAATCTAAGGCATCGCTTTACACCCATAACAAAATCCACACCGACAACTATCCTTATCCGTGTCTACATTGTGAAAAAAAATTCCGCAGAAGACAAGAACTATTATGCCATGTTTCTATGCATACCGGCGAAAAAAATTTCAAATGTGACGTGTGCTTCAAAAAATTTAGGCTTAAAACAGAGCTTAGAAGACACACCCTTATTCATTCGGATGATAAACCATTCGTTTGTATTATTTGCGGCTTTCGTTGTAGACAAGGACGATATTTGAACAATCATATGAAATTCAAATGCATGAAACTCGAAGATGACGAAGTGATCGCCATCCTAATGACGACGACGTCGCTGAAGAATCAGAAAAAACGAAAGTCGAGGGAACCATTGAATCCAGATGTAAGGCAAGGAAAATCTGGAGGGAAAAGCTGCAGCTCGAAAGAGGAAGTAGGGATCAATAGCGATGGGAGTAGTCGCAGCTTGCAACGCCGACTCGAGGTGGCCGGCTCGAAGGTAATCAACAATGGGGTGACGTACTACAAGTGCCGCAAGTGCCCGAAGCTTCTGTCAACTCCGTATAACTTCCTCGTGCACAACCGCATACACACGCGTGAAAAACTCTTCACGTGCGATATATGCAACAAGAACTTCACAGTCACTTCTTCGCTCACGCGCCACATACGCGACGTCCACGAAAAGATCAAGGATTACAGTTGCAATTTCTGTGAACGCAGCCTCGCTTCTAAAGTTGCTCGCGACGAACACCAGCGGACCCACACGAACGAGAGGCCTCACGTATGCAACACCTGCGGCAAAAGCTTCAGGCAACGGGCCTCCCTCTCTGTCCACAAGAGATTTCATTCCAAAAACTTTTCCTTTAGATGTAAGCTGTGTGAAAAGGCCTTTCCTCGGAAACAAGACATGGAGAGGCACGAGCTTACGCACACTGACCAGAAGCCCTACAGCTGCAAAGTCTGCGGGAAATCGTTCAGAAGCTCAGCCTCGGCGATCAGGCACAAACAGAGCCACGAGGTTCATAGCGTTTATAGATGTGACGTGTGCGGCGAAAGCTTCAGTCGAGAGCGATACTTGAAGAGTCACAAAAGTAAATGTCACAAAAACGATGGAGACAACTGA
Protein Sequence
MSNSLKKYNRKCNKKGVNSQKNPSDFLMCGDCGRLFKVKDSLMRHLRIHRDERPFTCHVCGKQFRDSGGLGRHIKDVHAGLKNHKCEICSRSFASKATRDDHQRIHTGERPYICDTCGKGFKSKASLYTHNKIHTDNYPYPCLHCEKKFRRRQELLCHVSMHTGEKNFKCDVCFKKFRLKTELRRHTLIHSDDKPFVCIICGFRCRQGRYLNNHMKFKCMKLEDDEVIAILMTTTSLKNQKKRKSREPLNPDVRQGKSGGKSCSSKEEVGINSDGSSRSLQRRLEVAGSKVINNGVTYYKCRKCPKLLSTPYNFLVHNRIHTREKLFTCDICNKNFTVTSSLTRHIRDVHEKIKDYSCNFCERSLASKVARDEHQRTHTNERPHVCNTCGKSFRQRASLSVHKRFHSKNFSFRCKLCEKAFPRKQDMERHELTHTDQKPYSCKVCGKSFRSSASAIRHKQSHEVHSVYRCDVCGESFSRERYLKSHKSKCHKNDGDN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-