Basic Information

Gene Symbol
-
Assembly
GCA_963859945.1
Location
OY982589.1:4682790-4703748[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.077 7.7 8.1 1.1 1 23 267 289 267 289 0.98
2 10 0.023 2.3 9.8 0.1 1 23 296 318 296 318 0.97
3 10 9.2 9.2e+02 1.6 4.2 1 23 322 344 322 344 0.85
4 10 0.00022 0.022 16.1 0.8 3 23 353 374 352 374 0.97
5 10 2.5e-06 0.00025 22.3 0.2 1 23 383 405 383 405 0.98
6 10 3.6e-05 0.0036 18.6 1.3 1 23 410 432 410 432 0.98
7 10 0.00023 0.023 16.1 0.3 1 22 441 462 441 466 0.93
8 10 0.0001 0.01 17.2 0.1 1 23 471 494 471 494 0.96
9 10 1.1e-05 0.0011 20.3 2.6 1 23 500 522 500 522 0.97
10 10 4.2e-06 0.00042 21.5 1.6 2 21 532 551 532 552 0.96

Sequence Information

Coding Sequence
atgtcttCGTTTTTGTGTTTCATTTGCCATAACGCTGTTAACGCAGATACAACTGAAGAGACGCGTGAAAAGTACCGAGAAGTCGTCGACATGAATctatGTCCTGACTCTCAGCTGTGCTTCATATGCTGTCATTTGGTCAATAAGCTGTGGTTTTTCAAGTCAATATGTATTAAACGAAGCCATGAGTATCCTATGCTGTTTAGcgaaaaatgttcaattaatttacacagaAGTGATattgaaacaataatattatgttcaGAGGAAACTTGCTTACCAAACAGCGCTACCCAGCTGTATTTTCGTTATACCAGCGATCACAGAGATCAGAGCAACGACTATGTTAAATTACAAGATGAGAATAACGATTATGATGAATACGTACCAGAAAACACTGCAGAAGATTATACAGCAGCTAATGAACCTTACAACACAGAATCGGTGTCAACGGTACCTTCTAGAACACAGCCAGATATAGAATATGACAGTTTACAGGCTGTCAATGATTTCAAGGGCTACAATTACACAAACACGGGTGTAGAAAATATGGATGCCACTGAATTAAATGAAACTGACGTTAAacctgaaaataataatgaagataTTGAAGATcatgttcataattttaattgtgataattttaatgaagaAAACGTCGAGGAAGCAGAAACTACTAAACACAATATCGAAAGTAAAAACAATGTAAAGGGCTATGAGAAGACTCTTCTCACTCTAGAAGAGCAGAAAGGAGAATTAGAAGGGCAGAGAAGAAGCAAGAAGTACTTAGACGCTGAGTTCAAATGCTATAATTGTGCTTTGGGCTTCCTGTTCAAGGATTCTTATCAAGCTCATATGATGCGGCATGAAgagTCCAATGGCGAATACGTATGTCTTCTGTGCACGCTTCGCTTTGCTAGCACCGCCGTGCTTCGTGCACACCGAGCCGTGCACAGAGAGCGATATATATGCAGTCACTGCGGTGTGAGAGTGCGAAAGAGACAACGAGATACTCACGCTAGAAAGTGTCATAAGAAAGAAGAGGATAGCGCCGCGTGCCATCTCTGTGGGAATGTGTTTCAAGATGCAAGTGGCCTCCAACAACATTTGAAACGGTTTCACATGAGTAAAACTAGTCATCGAACCTATTCCTGCAACATCTGTGGCAAGAGTTACGAGAACCAAGCCGCCGTCAGAACACATATGATaaaacacATCCAAAGGAAGTTTACCTGTGACCAATGCCCTGCCAACTTCAGTAGCCCGTACACCCTAACTCAGCACAAAAAGAAGCATTCCATTACAAGTACTGACAAAACACACGTTTGTGTAACTTGTGGGGTGGGGTATACCACCAGGAAAAGTCTGCTGGCTCATATGCGAACTGCTCTTCAGCATCAGGAGAGAGTatatgaCTGCCCAATCTGCAGCCGAATTTGTCCAAATCCCAGCGCTTTATCGGCCCACATATCTAGAGTGCATTCTGCGAACAAAGATTTTGCATGCAGTTTATGTGGTCACAAGTTCACGAGCCGGAAGTCCCTATTACGTCATATAAGGGAGCATACGTCACGGGTGAAGGTCAAGAAAGCGCAGTGTCATCTCTGTGGGAAGAGTTTTAAGGGTAACAGCAAGCTCAACAGGCATTTGAGGGAAGTGTGTGGCAAGGATAAATTAGAAGAAGAATTATCAGCTTATCACGAAcaacataatacaatattataa
Protein Sequence
MSSFLCFICHNAVNADTTEETREKYREVVDMNLCPDSQLCFICCHLVNKLWFFKSICIKRSHEYPMLFSEKCSINLHRSDIETIILCSEETCLPNSATQLYFRYTSDHRDQSNDYVKLQDENNDYDEYVPENTAEDYTAANEPYNTESVSTVPSRTQPDIEYDSLQAVNDFKGYNYTNTGVENMDATELNETDVKPENNNEDIEDHVHNFNCDNFNEENVEEAETTKHNIESKNNVKGYEKTLLTLEEQKGELEGQRRSKKYLDAEFKCYNCALGFLFKDSYQAHMMRHEESNGEYVCLLCTLRFASTAVLRAHRAVHRERYICSHCGVRVRKRQRDTHARKCHKKEEDSAACHLCGNVFQDASGLQQHLKRFHMSKTSHRTYSCNICGKSYENQAAVRTHMIKHIQRKFTCDQCPANFSSPYTLTQHKKKHSITSTDKTHVCVTCGVGYTTRKSLLAHMRTALQHQERVYDCPICSRICPNPSALSAHISRVHSANKDFACSLCGHKFTSRKSLLRHIREHTSRVKVKKAQCHLCGKSFKGNSKLNRHLREVCGKDKLEEELSAYHEQHNTIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00157481;
90% Identity
-
80% Identity
-