Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0087 0.65 11.2 1.3 1 23 67 90 67 90 0.97

2 6 0.00035 0.026 15.6 0.7 1 23 160 182 160 182 0.98

3 6 0.00018 0.013 16.6 2.2 1 23 186 208 186 208 0.96

4 6 0.016 1.2 10.4 2.1 1 23 213 236 213 236 0.94

5 6 0.018 1.4 10.2 0.7 2 20 244 262 243 266 0.85

6 6 0.00021 0.016 16.3 0.6 2 23 274 296 273 296 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0087	0.65	11.2	1.3	1	23	67	90	67	90	0.97
2	6	0.00035	0.026	15.6	0.7	1	23	160	182	160	182	0.98
3	6	0.00018	0.013	16.6	2.2	1	23	186	208	186	208	0.96
4	6	0.016	1.2	10.4	2.1	1	23	213	236	213	236	0.94
5	6	0.018	1.4	10.2	0.7	2	20	244	262	243	266	0.85
6	6	0.00021	0.016	16.3	0.6	2	23	274	296	273	296	0.96

Coding Sequence: ATGTTAGAAGCTCTGGTCATTCCTGTCAAAACGGAAACAAAGAAGACGAACATAATAGTGATAAATCCAAAAGAGGAAAGAGTTAAACTACAGCTGGTCACGAAAAGATTCAATGAGCTTAGCAAGCATCAGACGAACATAAGGACTATACTACTCTGCACAAACGCAACACCCATCCGCAAATATGGTGGCGTTGGGTACATGTGCTGTTTCTGTGATGGAGAGTACCCTGAGCCGAGTCTGCTGAAGAGTCACACCAGACGAtcacACGACAAATCGATCCTATCGACGTTTACCTCCACGTCATCAATGTCTAACTTAGTGGTGAAGCTTGACATAACCGACCTGAACTGCACTCTATGCGGCTCCCCGCTGTCATCAGTCGAGGCCGCGGCTGATCACCTGGTCGCCGCGCATTCTCAACCTTATTACAAGGAGCTGAAGAGCCATGTGCTACCGTTTAGATTCTCAGGGGGATTTCGGTGTGTTTTGTGTGAAAAGCAGTTTAGTAATTTTAAGGTTTTACTAGAACACATGAACGTACATTTCCGTAATCACGTGTGCGAAACTTGTGGTAAGGGATACGTCAACAAAGTGCAGTTTCAAACGCACACCTACCGCCACAAGACTGGACAGTTCGCGTGCAGCGTCTGTTCTAAAGTCTTTGATACACAGgTTAAGTGTCGCGAGCATAGGAGAGCTACGCACGTGTTAAATAACAAACGTAGTAAATGTGGGTACTGCGGCCAACGTTTCAAAGACTACACAAAGAAACGAGAGCACGAGGTCCTAGCCCACGGCGCGACGGGCGTCTCGCTCCAGTGTCGGGCCTGCGACAGAATCTTTAGCAACCAGCGCGCTTTGTCTGTACACACCAAGACTTATCATCTCATGGAGCGAACTGTGCCCAAGTGA
Protein Sequence: MLEALVIPVKTETKKTNIIVINPKEERVKLQLVTKRFNELSKHQTNIRTILLCTNATPIRKYGGVGYMCCFCDGEYPEPSLLKSHTRRSHDKSILSTFTSTSSMSNLVVKLDITDLNCTLCGSPLSSVEAAADHLVAAHSQPYYKELKSHVLPFRFSGGFRCVLCEKQFSNFKVLLEHMNVHFRNHVCETCGKGYVNKVQFQTHTYRHKTGQFACSVCSKVFDTQVKCREHRRATHVLNNKRSKCGYCGQRFKDYTKKREHEVLAHGATGVSLQCRACDRIFSNQRALSVHTKTYHLMERTVPK

Sequence clustering based on sequence similarity using MMseqs2