Basic Information

Gene Symbol
-
Assembly
GCA_955876795.1
Location
OY041623.1:9916072-9930579[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.072 6.1 8.4 8.8 1 21 309 329 309 332 0.96
2 10 0.011 0.97 10.9 9.9 1 23 339 361 339 361 0.98
3 10 0.82 70 5.1 2.9 1 23 365 387 365 387 0.96
4 10 8.6e-05 0.0073 17.6 6.3 2 23 393 415 392 415 0.97
5 10 0.00033 0.028 15.8 0.7 1 23 419 442 419 442 0.97
6 10 0.15 12 7.4 0.1 2 20 460 478 459 480 0.91
7 10 5.9 5e+02 2.4 6.8 3 23 517 538 515 538 0.86
8 10 1.6 1.4e+02 4.1 0.3 1 23 548 569 548 573 0.84
9 10 0.026 2.2 9.8 0.7 1 23 575 597 575 597 0.96
10 10 1e-05 0.00087 20.5 2.1 1 23 603 626 603 626 0.98

Sequence Information

Coding Sequence
atgtcgaaGTTGAAGATGTGCCGCATTTGTCTGAACAAAAACGTAAATGGTTATAAATTCGATGAATTCAACTTAAAACAGCTTTACGAACAACTTACAGGAATAAAAATGAAATCAGCAGATGATCTCCCGAACTGGTTCTGCTATGAGTGTAGCACATTACTGCACAAATTTCACAAGTTTAAGGATAAGTGCTTGAAAGGACAGAAACTTCTTCAGCAGCTATTGAAGCAGGGGCCTATTACGTATGAAGCAACTAAAAAAATTAACCGTGCAATAGAGCAGCTCAAAACCCTAAACATTATGGCAACGAACAAACACGTTAAAACATACATCACAAAACACAAATATATCGCTACAAGAACCACAAGAAGTCGGGGGAGGGTGAAAGCGAAACCTGTTGAAGTGATGATAGATTATAAGAGCGAGGATATCAAGAATGAGGATTCACCAATGATGGATGATCATATAGGGGATGTTGATGAtttggatgatgatgataataagaATGAGGTTGAAGCGGTAGacataaaagaagaagaaaaactaCCAGTACCAGAGAAAATCCTGGACATAATACCAGAACCCGATCCCGTGAAAAATAACATACCTGAGATCAGTAACGAACTAGATTCAGAAAGAAATGATCTCATCATGGACCTAGATGATGCTGATTATGTGCCAACTATTGATGATGACTTCCCGCCTATGGATGATGATCAGTCGTCCAGTGATGATGACTTTGGGGATAAGATTAAGGATGATAAGGACAAATCAGATTCAAAAGAGAAAAAGGTGAAATTCGCCCGGCAGAAACAAGAACACCTTAACCCCGACTTTTGGAAAAAGATACAAATGTCCGATGAAGAGGCATTATTCGAGTTTAAGAATCAGGAGCAAAGCGATAAGTACATTAAGGCGAACTACAAGTGCACAAACTGTTTTAAAGGATTCTCGAAGCATCATATGTTGGTGCGGCATCAGAAATGTCGGCATGAATTGaCCCTAGGTCCATTTGAGTGTCGGTTCTGCCACACGCGGTTCCGGCGCAAATGTCGTCTAACGCAGCACATGAGACAACACTATGCGATCTACCACTGTCTGCGCTGTGACATGCGATTCAGAGTCGAACATTCAGCAATCATCCATGAACGTTACCACAGTGGCCAGCTCACGAAATGCAAGCATTGCGGCGAAGAGTTCAAACACAGATCTACGTACTACTCGCATATGAGAATGTCGCACCGCAGCAACCACGTGTGCAGCCTGTGCGGCGCGTCGTTCTTCAGCGAGGGCGGCCTCACGCAGCACCGGAGGATCAAGCACTTCGATAAGGATACACCGGGAACATCATCAGAAAACGTAATAATGAAGATCTACTGTGAAAAGTGCGACATTAAGTTCGTATCGCAACAAGCCTATGACGAGCATCTGGTGCACTCGAATCGACACGATGAgGTCATCACGGATACGGAGATAAAGCGAAAAAACCTGAAGGGGAAGAAACATCTTGCTACGGGACCCTATAAGAGGAAGAAGCCAACCACTTGTATTCACTGCGGTAAACACTTCTCATCCCAAACCGCGTGTATGAAACACCATCTAGCGGAGCACCCTCGCAAGACGTTCCAGGACCAAAGACACATCTGTGAGATCTGCGGGGCTTCGCTAGCGGCCGTCTCAATAACGAGTCATATGAACATGCACACCCGTGAGCACGTGTTTCCTTGCGGAATCTGCGGGATGGAGTTTATATCCAAACGGAGTCACGACAGGCATCAAGTCACACACACAGGAGAGAAGCCCTACCCCTGTCCGCTCTGCGAGAAGCGATTCACCCAGAAGAACAGCATGAAGCTGCACTACAGGACCTTCCACTTGAAGATGCCATATCCACCGAGAAATAGAAAGAGCAAGACAGACGAAACGCCCCTGAATGAAGCGTGTCGAGAACGAGACGTCGAAAGTAACTTCTTCCCGATCGGTAGATGGCGCTGA
Protein Sequence
MSKLKMCRICLNKNVNGYKFDEFNLKQLYEQLTGIKMKSADDLPNWFCYECSTLLHKFHKFKDKCLKGQKLLQQLLKQGPITYEATKKINRAIEQLKTLNIMATNKHVKTYITKHKYIATRTTRSRGRVKAKPVEVMIDYKSEDIKNEDSPMMDDHIGDVDDLDDDDNKNEVEAVDIKEEEKLPVPEKILDIIPEPDPVKNNIPEISNELDSERNDLIMDLDDADYVPTIDDDFPPMDDDQSSSDDDFGDKIKDDKDKSDSKEKKVKFARQKQEHLNPDFWKKIQMSDEEALFEFKNQEQSDKYIKANYKCTNCFKGFSKHHMLVRHQKCRHELTLGPFECRFCHTRFRRKCRLTQHMRQHYAIYHCLRCDMRFRVEHSAIIHERYHSGQLTKCKHCGEEFKHRSTYYSHMRMSHRSNHVCSLCGASFFSEGGLTQHRRIKHFDKDTPGTSSENVIMKIYCEKCDIKFVSQQAYDEHLVHSNRHDEVITDTEIKRKNLKGKKHLATGPYKRKKPTTCIHCGKHFSSQTACMKHHLAEHPRKTFQDQRHICEICGASLAAVSITSHMNMHTREHVFPCGICGMEFISKRSHDRHQVTHTGEKPYPCPLCEKRFTQKNSMKLHYRTFHLKMPYPPRNRKSKTDETPLNEACRERDVESNFFPIGRWR