Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 5.6e-05 0.0048 18.2 0.1 2 23 173 193 172 193 0.96

2 6 3.2e-06 0.00027 22.1 2.1 1 23 200 222 200 222 0.98

3 6 0.0021 0.18 13.2 0.4 1 23 228 250 228 250 0.99

4 6 0.00022 0.018 16.4 1.2 1 23 256 278 256 278 0.98

5 6 0.017 1.4 10.4 2.1 1 23 283 306 283 306 0.89

6 6 1.2e-05 0.001 20.3 0.5 1 23 312 335 312 335 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	5.6e-05	0.0048	18.2	0.1	2	23	173	193	172	193	0.96
2	6	3.2e-06	0.00027	22.1	2.1	1	23	200	222	200	222	0.98
3	6	0.0021	0.18	13.2	0.4	1	23	228	250	228	250	0.99
4	6	0.00022	0.018	16.4	1.2	1	23	256	278	256	278	0.98
5	6	0.017	1.4	10.4	2.1	1	23	283	306	283	306	0.89
6	6	1.2e-05	0.001	20.3	0.5	1	23	312	335	312	335	0.95

Coding Sequence: ATGTTAGCTTATTACTACCAggctacaaaaaataaaataaagaacgAAGCAGAGATCTCGAATTACTACAATGATTTACTAAAAATTAACTCTACTGTTCGAAACCTTTCTTCAGCATGTAGAGTGTGTCTAAAAGAAggaaatatatctatctatacacaGAGCAACAGCAAGGAATTGATTGAAGCGCTAAAAATCTTTGGAAACATTCATTCCAAAGATGACAACATTCATTTGTGTTCCGTTTGTctaaaatttatcaaaacagCAATTTCATTTCGCCAAGTCGCTCTCCGATCAGATGCGTTATTCAAAACATCAGTCAAGgacataaaagttaaaattgagCTGAcacttgatgatgatgatgatgaccggCCTCTTGTCATTCATATAGAAGACCCAGTAACTAAACACCAAGATGTTTTAAGCAAAAAGTCAGACCATGTACCTAGCAAAGACTCAGACCAGAAATTAGGAATAcctaaagaaagaaaatataaaactacCAAAGTATCATGCCCTGAATGTGGCAAAGTGGTAACAAACTCTGCTCTAAAACAGCACATGTTGCTGCAtgatccaaataaaaaaaagtatgtttgccATATCTGTGGTAAAACCTTTTCACTACCCATGTCGTTTCGCAGACACAGTTTGACGCATGGAACCGACTTTCCATACAGATGTAAGCTCTGTCCCTACCGTGGGCAATTAGCTGAACTTTTAAGAAGTCATATGCGTTCCCACACTCTTGATTACAGATACATGTGCACAGAATGCCCGGCAAGATTCTTACACATCAGCAATATGAATAGGCACATGCGAATTCACAAAGAGCCACAGTTCAAATGTGATACATGCAAGAAAAGTTTCCATACTAAACTGATCATGGAAAGACATATTGAATTGGTACATTTAGGGATCAAAAACCATGTTTGCAGTATTTGCGACAAAGCATTTGGcacaagaaaagccttaaggaaTCATGAAAGGGGAGTGCATAAACACAAAAAGGTGTCCTATAGAAGAATGCCATTATATTTAAAAGCAGCAAATTTGAATAAGGAttcaacttga
Protein Sequence: MLAYYYQATKNKIKNEAEISNYYNDLLKINSTVRNLSSACRVCLKEGNISIYTQSNSKELIEALKIFGNIHSKDDNIHLCSVCLKFIKTAISFRQVALRSDALFKTSVKDIKVKIELTLDDDDDDRPLVIHIEDPVTKHQDVLSKKSDHVPSKDSDQKLGIPKERKYKTTKVSCPECGKVVTNSALKQHMLLHDPNKKKYVCHICGKTFSLPMSFRRHSLTHGTDFPYRCKLCPYRGQLAELLRSHMRSHTLDYRYMCTECPARFLHISNMNRHMRIHKEPQFKCDTCKKSFHTKLIMERHIELVHLGIKNHVCSICDKAFGTRKALRNHERGVHKHKKVSYRRMPLYLKAANLNKDST

Sequence clustering based on sequence similarity using MMseqs2