Basic Information

Gene Symbol
ZEB2
Assembly
GCA_963564075.1
Location
OY751097.1:13731216-13732514[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 2.3 1.9e+02 3.7 0.3 1 12 9 20 9 23 0.87
2 10 6.9e-05 0.0056 17.9 0.3 1 23 126 149 126 149 0.96
3 10 0.0009 0.072 14.4 4.2 1 23 167 189 167 189 0.98
4 10 5.3e-05 0.0043 18.3 0.8 5 23 198 216 195 216 0.95
5 10 8e-07 6.5e-05 24.0 4.8 1 23 222 244 222 244 0.99
6 10 0.0011 0.088 14.1 5.1 1 23 249 271 249 271 0.98
7 10 1.8e-05 0.0014 19.7 0.4 1 23 277 299 277 299 0.97
8 10 7.6e-05 0.0061 17.8 1.4 2 23 306 327 305 327 0.97
9 10 0.00072 0.058 14.7 0.6 2 23 334 355 333 355 0.97
10 10 1.5e-06 0.00012 23.1 1.7 1 23 361 384 361 384 0.97

Sequence Information

Coding Sequence
ATGGATAATCACATTAGCTCGAGACATGTTTGTAGTATTTGTTTGGAAAGTTTCAAGAAAGATACACATTCTGTAGAGACAGCAGTAGACCCCAAAGAAGTTTGGGAAAAGCTATCTTGGTGTTTTCAAATCACTTCTAACTTTGAAAAGGATCTACCTTATTCATTTTGTCGACAATGCTTGGAAGATTTGGAAACATCATGCCGCTTCAGAATGACATGTATGACTAACCATGAACATTTTCAAGAATACTACAAAAAACGATCTGAAATTACTTTACTAGATAATTCTGAAGTATATGAAGATAGAGAAGTTTTGGAAGATACTCAGTCTGAACTCAAGGAAGATACAATATCATTaaatgaaaaagaaacatttatttgtgATCTCTGCAATAAAGTTCTGATAACAAAGAAGTCCTTAATGAAACACATTGTAACTATGCATGAGAAACGTGATCACCCAGGAAAAGTGACAGGTTTTGGGGGTTCTCGACAATATCACTGCACAAGTTGCCCTTACTCTACTCCTCACAGCCAGACTCTAATCAACCACATGAGGCGACATAGTGGCGAGAGGCCATTTAAGTGTGAATGTGGAAAGAGCTTCACGCAGACATCTAGCCTTGCTGCTCACCGCAAAATTCATAGTTCAACAACATATTATACATGCACTAAATGTGGGAAACAATTTAAACATGCCTTCTCATTAAAAACCCATATGAAAGTACACAGTAATGGCACCTTCTCCTGTCATATTTGTACCAAAGTCCTAAAATCCAAGAGGACTTTGGCTAGTCACTTGCATAGGCATTACAAAATCTATAAATTCAACTGTGAGGATTGTGGGAACACTTTTGTGACATCAGCAGAGTTGCTCAACCATAAAAATAAGCATAGAACGAAGAAAAATATTGTTTGTCATTTCTGTGATTATGCAACAAACTCAAAAAAGAACCTAATAGCTCATCTCAAACGACATGAAGGTGAAAAAGCAAGCAAGTGCATGTTCTGTGAAAAGGCCTTTCTCACAGATGGAAACCTACGGCGGCATATACGCGTCCACACACGTGAAAAACCTTTCATATGCAACATATGCACACAGAGATTTGCACACAGTTCAAGTCTAAACAATCATATGCTAACTCTCCATGGAGTGAAATACAAATGGGGAGAGGACAAACTGAAAAGCAAGACTTTAAAAACGGAAAATAATGAGTAA
Protein Sequence
MDNHISSRHVCSICLESFKKDTHSVETAVDPKEVWEKLSWCFQITSNFEKDLPYSFCRQCLEDLETSCRFRMTCMTNHEHFQEYYKKRSEITLLDNSEVYEDREVLEDTQSELKEDTISLNEKETFICDLCNKVLITKKSLMKHIVTMHEKRDHPGKVTGFGGSRQYHCTSCPYSTPHSQTLINHMRRHSGERPFKCECGKSFTQTSSLAAHRKIHSSTTYYTCTKCGKQFKHAFSLKTHMKVHSNGTFSCHICTKVLKSKRTLASHLHRHYKIYKFNCEDCGNTFVTSAELLNHKNKHRTKKNIVCHFCDYATNSKKNLIAHLKRHEGEKASKCMFCEKAFLTDGNLRRHIRVHTREKPFICNICTQRFAHSSSLNNHMLTLHGVKYKWGEDKLKSKTLKTENNE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00704288;
90% Identity
iTF_00705335; iTF_00704288;
80% Identity
-