Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.3 20 6.3 0.3 3 17 161 172 160 179 0.73

2 6 1.3 86 4.3 0.1 5 23 188 207 185 207 0.83

3 6 0.00054 0.035 15.0 0.1 1 23 212 235 212 235 0.93

4 6 0.011 0.75 10.8 1.2 1 17 244 260 244 267 0.88

5 6 3.8e-05 0.0025 18.6 0.9 2 23 274 295 274 295 0.97

6 6 1.4e-06 9.5e-05 23.1 1.2 1 23 301 324 301 324 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.3	20	6.3	0.3	3	17	161	172	160	179	0.73
2	6	1.3	86	4.3	0.1	5	23	188	207	185	207	0.83
3	6	0.00054	0.035	15.0	0.1	1	23	212	235	212	235	0.93
4	6	0.011	0.75	10.8	1.2	1	17	244	260	244	267	0.88
5	6	3.8e-05	0.0025	18.6	0.9	2	23	274	295	274	295	0.97
6	6	1.4e-06	9.5e-05	23.1	1.2	1	23	301	324	301	324	0.97

Coding Sequence: ATGATATACTTGCAGATTGAAAATCTTGATGGGTACCCTGAGAATATCTGTGAGTCCTGCAATACCATACTGGATACTGTGTACAAATTTATCACAAAATACAAAACAAGCAGCGAGATACTAGAATGTGGCCTTACTGTAGTTAAAGAGGAAGTTGATATTGAAATCTCAGAAGGAGCATTTGAAATAGAAATTTTAAAAAATGAACCGTTATCTGACTACGATGACTGGGCTTTCCTGGAGCCACAGGTCCAAAGACCAGATAATTCTTTGACAGAAATCAAGGCAAAGCTCAAAAATCTCAAGGAAATTGATATCAAACAGGCACCAGTTCGAAAAAGCCCCTGCAAAACCAGTAGAGTAGTTTTATCTGTTTTGGAAGACTGGAATGGAGAAAGGTCTGAAAACAATAAGGAAATAACCAAACAACCAATGCAAAACCTAAAGCTGTCACCACCAGTGTATGGGAAGAAAAAACTATGTGACTTATGTGGAGAGGCTTTTACAAATCTTGATACACACATAAAGAATAAGCATAACAAAAAGAACGTAAGATGCATCCTGTGTTCAGTGGTTTTGTCAGGTGAACGAGGCTTAAAACGGCATATGCAAGCAATACACAATGACAAGCCTTTTATTTGTGAAACATGTGGAAAACGCTTCGGTGTCAAAAGAGTTTTAAAGTCTCACATAGAGGGAGTTCACTTAAAAACTAAGAAAAAGATCAAATATCCATGTCACAAATGTGACAAGGTATATATTTCTAAAGTGGGTCTTATCTGCCATGATAGAAATGTTCACACTGGATTTAGACCAGCTGTATGCGAAGAGTGTGGGAAAAGCTTCGTCTGTGCATCCTATCTCAGGGAACATCAGAGATTACACACAGGAGAGACACCATACAAATGTCCCGTTTGTGGCCGCGGATATGCTCAAAAAGGCAATATGAGAAGCCATATGAAACATAACCACCGAATGGCTGATTTAAGCCTGGAATTGTTGAGAACTAAACCAAGTTGGTTAAAATATTTAAAGAGGTCTTAA
Protein Sequence: MIYLQIENLDGYPENICESCNTILDTVYKFITKYKTSSEILECGLTVVKEEVDIEISEGAFEIEILKNEPLSDYDDWAFLEPQVQRPDNSLTEIKAKLKNLKEIDIKQAPVRKSPCKTSRVVLSVLEDWNGERSENNKEITKQPMQNLKLSPPVYGKKKLCDLCGEAFTNLDTHIKNKHNKKNVRCILCSVVLSGERGLKRHMQAIHNDKPFICETCGKRFGVKRVLKSHIEGVHLKTKKKIKYPCHKCDKVYISKVGLICHDRNVHTGFRPAVCEECGKSFVCASYLREHQRLHTGETPYKCPVCGRGYAQKGNMRSHMKHNHRMADLSLELLRTKPSWLKYLKRS

Sequence clustering based on sequence similarity using MMseqs2