Basic Information

Gene Symbol
-
Assembly
GCA_947086465.1
Location
OX352256.1:4355251-4356564[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0036 0.23 12.3 0.1 1 23 118 141 118 141 0.94
2 10 0.0091 0.58 11.0 0.1 2 23 168 190 167 190 0.95
3 10 0.0049 0.31 11.9 2.5 2 23 213 234 212 234 0.98
4 10 0.00017 0.011 16.4 1.6 1 23 238 260 238 260 0.97
5 10 4e-07 2.6e-05 24.7 1.9 1 23 265 288 265 288 0.98
6 10 0.029 1.8 9.4 2.7 1 23 294 317 294 317 0.95
7 10 5.1e-05 0.0032 18.1 3.3 2 23 325 347 324 347 0.96
8 10 7.9e-05 0.0051 17.5 2.5 1 23 353 375 353 375 0.98
9 10 3.6e-06 0.00023 21.7 1.4 1 23 381 403 381 403 0.99
10 10 0.068 4.3 8.3 6.1 1 23 409 432 409 432 0.98

Sequence Information

Coding Sequence
ATGGCCTACAGTGAACTCAAAATTAAAACAGAAGTAAGTGAATCTGAAGACGCTGAAGATGTTAAGCCTAAAATTCAGGAAATATTTTGCAATATCCCAGTCAACCCATCATCCAAGCAACGTCATAAAACTTCTAGTGCACAACGTAAGATAAAACGACCAACGATTCTACGAAGACCAATAAAGGAGACAACTTTAAAGAAAAGTCCGCCTTCTGGTAGTATTCAAATAAAACCAGCCGCAGAAAATTTTCCGGAACAAAAAGAAGTcgaaaaacagcgatataatattcaaacaattttgctaaactctaacgcgacaccaataaaaaactactccctagccagcggttacaactgtgctttctgcaaagttaccttcccagtaccggcggacctcaaagcgcatacaataaatgatcacgacgaccaaactaaaaagagtttaatgaaaaatatatttttattttcttacatagttaaactcgacatcactggactaagctgtaacacttgtaatacaattttagacgatgtagacgaacttatccgccatctaaacagcgtacaccagaaaggattacatactgatgtaaaaagttacattgcctcctttaaattcaacggggaggaaacaaaatgtcacatttgctctgtcgaatatcgtaacttcaaagttttacaagaacacatgaacaaacactccatgaactttatttgtcatgagtgtggaatcggctgcattaatttgagtcaacttaagaatcattccataactcacgtatctgggacatttaaatgcacaaaatgcgataaagtttacaaatccaacctcaacctacagacgcacattcgacgaattcattccggtaaacccatgtacaagtgcaaccattgcgaggatcgatttaaaaatatatataccaaaagaaatcacatgatagaagcacatggaatcgtatttgccgattcagaatgcaattcatgcaataaaacgttcaaaaccccacacggacttcgcttgcacaagaggagagatcatttaatggaaaggcggcacaagtgcaatgtttgcgagcgtacgttcttctcagcgacgtcactgaagaatcatgagataacgcatacggggcagagggatttcaaatgcgatgtttgctctaagtggttttcgagaaagtacgcccttacagagcacatgcggtcgcacactgacgaccgacggttcaagtgctcttactgtgccataacgttcctgcataagtgcagcctgaaaggacacttgcgcactcgacacgATGCTGAACTACAATAG
Protein Sequence
MAYSELKIKTEVSESEDAEDVKPKIQEIFCNIPVNPSSKQRHKTSSAQRKIKRPTILRRPIKETTLKKSPPSGSIQIKPAAENFPEQKEVEKQRYNIQTILLNSNATPIKNYSLASGYNCAFCKVTFPVPADLKAHTINDHDDQTKKSLMKNIFLFSYIVKLDITGLSCNTCNTILDDVDELIRHLNSVHQKGLHTDVKSYIASFKFNGEETKCHICSVEYRNFKVLQEHMNKHSMNFICHECGIGCINLSQLKNHSITHVSGTFKCTKCDKVYKSNLNLQTHIRRIHSGKPMYKCNHCEDRFKNIYTKRNHMIEAHGIVFADSECNSCNKTFKTPHGLRLHKRRDHLMERRHKCNVCERTFFSATSLKNHEITHTGQRDFKCDVCSKWFSRKYALTEHMRSHTDDRRFKCSYCAITFLHKCSLKGHLRTRHDAELQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00701352;
90% Identity
iTF_00706347;
80% Identity
-