Basic Information

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.035 3.7e+02 2.3 0.0 32 52 5 25 1 29 0.73

2 4 0.0038 40 5.4 0.2 33 40 76 83 29 140 0.65

3 4 0.0056 59 4.8 0.1 32 41 159 168 125 210 0.60

4 4 0.0021 22 6.2 0.0 13 13 238 238 192 288 0.60

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.035	3.7e+02	2.3	0.0	32	52	5	25	1	29	0.73
2	4	0.0038	40	5.4	0.2	33	40	76	83	29	140	0.65
3	4	0.0056	59	4.8	0.1	32	41	159	168	125	210	0.60
4	4	0.0021	22	6.2	0.0	13	13	238	238	192	288	0.60

Coding Sequence: ATGCTGCAAATTCAGAAGTTCCCTGGACGAAACCACACAGTAGATGCAGCTGTACTGAAGTTCCCTGGACGAAACCACACAGTAGATGCAGCTGTACTGAAGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTCCGTGGACGAAACCACACACTAGATACAGCTGTACAGAAGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTCCGTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGTTGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTCCGTGGACGAAACCACACTCTAGATGCAGCTGTACAGAAGTTCCGTGGACGAAACCACACACTAGATACAGCTGTACAGAAGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTCCGTGGACGAAACCACACACTAGATGCAGCTGTACTGAAGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTTCGTGGACGAAACCACACACTAGATGCAGCTGTACTGAAGTTCCCTGGACGAAACCACACACTAGATACAGCTGTACAGAAGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTCCGTGGACGAAACCACACACTAGATGCAGCTGTACTGAAGTTCCCTGGACGAAACCACACACTAGATGCAGCTGTACAGAAGTTCCCTGGACGAAACCACATAGTAGATGCAGCTGTTCTGAAGTTCCCTGGAAGAAACCACGCAGTAAATACAGCTGTACAGAAGAttgcgaaaataaattattaa
Protein Sequence: MLQIQKFPGRNHTVDAAVLKFPGRNHTVDAAVLKFPGRNHTLDAAVQKFRGRNHTLDTAVQKFPGRNHTLDAAVQKFRGRNHTLDAAVQKFPGRNHTLDAAVQLFPGRNHTLDAAVQKFRGRNHTLDAAVQKFRGRNHTLDTAVQKFPGRNHTLDAAVQKFRGRNHTLDAAVLKFPGRNHTLDAAVQKFRGRNHTLDAAVLKFPGRNHTLDTAVQKFPGRNHTLDAAVQKFRGRNHTLDAAVLKFPGRNHTLDAAVQKFPGRNHIVDAAVLKFPGRNHAVNTAVQKIAKINY

Sequence clustering based on sequence similarity using MMseqs2