Basic Information

Gene Symbol
-
Assembly
GCA_943735975.1
Location
CALSER010000021.1:1031523-1033582[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00013 0.0078 16.9 1.0 2 23 113 134 112 134 0.97
2 13 0.021 1.2 9.9 1.0 1 23 140 163 140 163 0.94
3 13 3.7e-05 0.0022 18.6 0.8 1 23 169 191 169 191 0.97
4 13 6.6e-06 0.00039 21.0 2.6 1 23 197 219 197 219 0.98
5 13 1.6e-06 9.2e-05 22.9 6.0 1 23 225 247 225 247 0.97
6 13 1.9e-06 0.00011 22.6 1.4 1 23 253 275 253 275 0.99
7 13 1.1e-05 0.00067 20.2 0.1 2 23 282 303 281 303 0.97
8 13 0.0023 0.14 12.9 3.3 1 23 309 331 309 331 0.97
9 13 5.7e-08 3.3e-06 27.5 5.4 1 23 337 359 337 359 0.98
10 13 0.0019 0.11 13.2 5.3 1 23 365 387 365 387 0.97
11 13 9.6e-05 0.0056 17.3 0.3 1 23 393 415 393 415 0.99
12 13 5.1e-07 3e-05 24.4 1.3 1 23 421 443 421 443 0.97
13 13 1.5e-06 8.7e-05 23.0 2.8 1 23 449 471 449 471 0.98

Sequence Information

Coding Sequence
ATGCATCAAATTGGAAACACCTATCTTCAAGGAGTTTATGAGAGATTCACTGGGAACATGATTACTGAAAAGACCATTGCTGAACACAACCTTGGTTGGCTGCATAACTTGTCAATGTCTCCCGTAAAAACCCTGTCCACATATGAAGAGGTCACCAACAATGTTGAAATAATCTTCAAGGAAGAAAGAACATCAGATGATGAATCCTTTGTGCTAGATAGCCTTGAGACTTTTGTTGATGTTATCAAAATGGAAGCCATTTCACACGAGGACAAGCCTAATTCCAAAGACAAATTTAATTATACACATAACATTGTTGACTACAATTTACCTATTTCCTGTGAAAAATGCAAAAAAACCTTTGAAAGTGAAGCTAGGCTTGAGAGGCATAAATTAACACACAATAAAGTGAAGTCATACAACTGTGAGTTTTGTATGAAAGTATTCCCCATGAAGAAACTGTTGAAAGTACACACAGTAAAGAATCATACTGGCGAAAAGCCCTACGCCTGCGAAAGCTGCGACAAAAGATTTAACCGTAAACGTCTCCTGATCGAACACAACCGGATCCACAGTGGCGAAAAGCCATATAATTGTGAAGTTTGCAACAAGTCATTTGCCCAAAGTTCCACTCTGAGATGCCACATGAGGGTGCATACAGGTGAGAAGCCCCACATGTGCAATATTTGCAACGAGTCATTCACTCGTAAACATTCCTTGAACAAGCACCTGCGCTCTCACAGTGGGGAGAGGCCTTACACCTGCAATACTTGCAACAAAAGCTTCTCAGCTAAAAGTGTTTTGACTGTACATATGCAACGGCACACAGGTAATAAACCTATAACATGCAAGGTTTGCAACAAAACATTTGCTGTGAAAGATGGCTGGCTGGCACACATGCGGATTCATAATGGAGACAAGCCATTTATCTGCAGTACATGCGGTAAATGCTTTCTTCGTAAAAATCAACTGGTTTTTCACATGAGAGTACATTCTGGTGAAAGGCCACACAGTTGCAACATTTGCAATAAGTCATTCACACATCCTTCTACTCTGACAAGTCATATGCGAACTCACACTGGAGAAAAACCATACAGTTGCAATATATGTAAGAAGTCATACAAGCATAGTGGTACCCTAGCTTGTCATATGCAACAGCATTCTGGTGAAAAGCCTTTTAAATGTTCTATATGCAATAGATTATTTGCTATAAAACCACTTTTGAGGCAGCACATGGCAACCCACACAAATGAGAAGCCTCATGTATGCGATATTTGCGATAAACCATTTATGCGCAGCACTTCTCTCAAGCGTCATATTAAAATTCATACAGGCGAAAAGCCCTATAACTGTAATTTATGTGAGAAAAAGTTTCCTCGCAAAGATTTTTTAAAGCAGCATATGAAAACACACTCTGGAGAGAGATTGTACTATACATAG
Protein Sequence
MHQIGNTYLQGVYERFTGNMITEKTIAEHNLGWLHNLSMSPVKTLSTYEEVTNNVEIIFKEERTSDDESFVLDSLETFVDVIKMEAISHEDKPNSKDKFNYTHNIVDYNLPISCEKCKKTFESEARLERHKLTHNKVKSYNCEFCMKVFPMKKLLKVHTVKNHTGEKPYACESCDKRFNRKRLLIEHNRIHSGEKPYNCEVCNKSFAQSSTLRCHMRVHTGEKPHMCNICNESFTRKHSLNKHLRSHSGERPYTCNTCNKSFSAKSVLTVHMQRHTGNKPITCKVCNKTFAVKDGWLAHMRIHNGDKPFICSTCGKCFLRKNQLVFHMRVHSGERPHSCNICNKSFTHPSTLTSHMRTHTGEKPYSCNICKKSYKHSGTLACHMQQHSGEKPFKCSICNRLFAIKPLLRQHMATHTNEKPHVCDICDKPFMRSTSLKRHIKIHTGEKPYNCNLCEKKFPRKDFLKQHMKTHSGERLYYT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00702227;
90% Identity
iTF_00702227;
80% Identity
-