Basic Information

Gene Symbol
Scrt1
Assembly
GCA_945859775.1
Location
CAMAOS010002110.1:10513-22999[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 1.9e-07 2.4e-05 25.3 1.6 1 23 460 482 460 482 0.99
2 5 0.00062 0.081 14.2 0.3 2 23 492 513 491 513 0.97
3 5 1.4e-05 0.0018 19.4 0.4 1 23 517 539 517 539 0.97
4 5 4.6e-08 6e-06 27.2 0.6 3 23 547 567 545 567 0.98
5 5 6.6e-05 0.0085 17.3 2.2 1 21 573 593 573 594 0.94

Sequence Information

Coding Sequence
ATGCCACGTTGTTTAATGGCTAAAAAATGGAAGGCATATCCTTGGCCCGACCGAACTGAATCCAAACACATAAGCAACAGCATCAGCTGCAACAACAACAATAACAATAATTCACAAATTTTGGATGACGAGGAGGACGATTCCTCATCCGAGTGCAATTTGCAAATTGTCATTGAAGAAAAAATTCCAACAACACCAACAACGAATCAACAAAGTGTGATTGTTGATTTACCAATAAGTGTTGATGATGACGAAGAAATTGATGTTGTTGGTGATAATACATCGGCGACATTAATTCATGGAAAACATCAGCACCAACATCAACATCAGCATCAACAACAATTAGATCAACGCACAACATCATCAACGACAACAACAGCATCAGCTACAACAGCAGCAGCATCTTCTACAACGCCATCTACCTGTTGGGGTCCATCTTCACCAACAGCGGGCGCCACGGCACCTAGTCCACCTCCCCATTCACCGGAAGCGGCAACGCGTGGTTCAACAACTTTATATAATGGATATGGTCACGACGCATCGCCAATGCACTTCACTGCGTACCTGCCACGAATGGAGAACGAAGTAACCGTTATCACATCACATCCGCCCCGACCCCCATTGGCGTCACCGACCTCTAATTCCTCTCAATATTCCTATCAGACAAATTCTTCTTCTTTGTCTTCGCCATCCTCACCCTCGAATTCGTCGGATCGCTTTAGTCCGCCTATGATTCGCATTAAGACCGAGTACGACAACGACTTACATCACAATAACAACAACGTTAATAGAAAATCCCTAGCCATGTGCTTTACAAGCACAGGAGCAGCTCTGTCATTGCCTCCAAAGAAAAAGGACATTTACCGGCCGTATTCGCTGGACGATAGGCCATCGGCCATTGATCGCATTCGAACCTATGAAATGCGAATACCGGCTGAGGAGGATTTGCATGCAGCACATGCAATTCTGGATCTGAGTGCGTCAACAGCCTTCCATCCACCAACGCAACCGCATCAGTTGCAACAACTTCAGCAACAACAGCCAGCTCATCATTTGCATCATTTGACGCATGCGATACAGTTGCAACAGCAGCAGGAGGATGACGACGAACGCCCCGATAGCCAACTATCGATGCATAACGGACATGTACCTGAAGTTGACTGCAAGAGTGGTCCCATTCAGAATGAGAACAGCAACACGACGAACATTGGGGCGCAACAAATCGGTTCGTGTTCCAGTAGCCCGGGCACTCCACAGCCCGGTGCCAAGACCGTTGCCTACACATACGAAGCCTTCTTCGTTAGTGATGGGCGTTCAAAGCGGAAAAACGCAACCGATCCGGCTGCCGCAGTAATCGTGCCCGAGCACAAGGCAAAGTACACAtgcacagaatgtggcaagcaatatgcaacatccagcaatctgtcgcggcacaaacagactcatcgcagtttggactcccagtcggcgaaaaaatgccacacctgtggcaaggcctatgtgtccatgccggccctggcgatgcacgttctcacgcacaaactctcacacagctgcggtgtctgcggcaagctcttctcccggccttggctgctccagggtcaccttcgatcgcataccggcgaaaagccctacggttgcgcccattgtggcaaagcattcgccgaccgttccaaccttcgagcgcacatgcaaacacattcgatagacaagaacttcgagtgtaaacgctgtcacaagaccttcgctcttaaatcctacctgaacaaacaTCTCGAATCGGCCTGTTTGAAAGACGAAGGCTCCTCCGATTACTCCGATCCCATGAGTCCCGAACCACCATCATCGATGATGCTCGATATGGTCAAAAGCAGTCCAATCAGAACAACACCAGTTAAAATCGAAGCCTCCTACGGTGGGTAA
Protein Sequence
MPRCLMAKKWKAYPWPDRTESKHISNSISCNNNNNNNSQILDDEEDDSSSECNLQIVIEEKIPTTPTTNQQSVIVDLPISVDDDEEIDVVGDNTSATLIHGKHQHQHQHQHQQQLDQRTTSSTTTTASATTAAASSTTPSTCWGPSSPTAGATAPSPPPHSPEAATRGSTTLYNGYGHDASPMHFTAYLPRMENEVTVITSHPPRPPLASPTSNSSQYSYQTNSSSLSSPSSPSNSSDRFSPPMIRIKTEYDNDLHHNNNNVNRKSLAMCFTSTGAALSLPPKKKDIYRPYSLDDRPSAIDRIRTYEMRIPAEEDLHAAHAILDLSASTAFHPPTQPHQLQQLQQQQPAHHLHHLTHAIQLQQQQEDDDERPDSQLSMHNGHVPEVDCKSGPIQNENSNTTNIGAQQIGSCSSSPGTPQPGAKTVAYTYEAFFVSDGRSKRKNATDPAAAVIVPEHKAKYTCTECGKQYATSSNLSRHKQTHRSLDSQSAKKCHTCGKAYVSMPALAMHVLTHKLSHSCGVCGKLFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTHSIDKNFECKRCHKTFALKSYLNKHLESACLKDEGSSDYSDPMSPEPPSSMMLDMVKSSPIRTTPVKIEASYGG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00992079;
90% Identity
iTF_00984523;
80% Identity
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