Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 9.4e-05 0.024 17.1 0.2 1 21 55 75 55 76 0.96

2 6 0.00047 0.12 14.9 1.8 1 23 84 107 84 107 0.97

3 6 1.5 3.7e+02 3.9 2.6 2 21 175 194 175 195 0.91

4 6 4.9 1.2e+03 2.3 2.4 3 12 205 214 203 216 0.90

5 6 0.00019 0.047 16.2 1.7 3 21 233 251 232 252 0.94

6 6 0.054 13 8.5 5.6 1 23 260 283 260 283 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	9.4e-05	0.024	17.1	0.2	1	21	55	75	55	76	0.96
2	6	0.00047	0.12	14.9	1.8	1	23	84	107	84	107	0.97
3	6	1.5	3.7e+02	3.9	2.6	2	21	175	194	175	195	0.91
4	6	4.9	1.2e+03	2.3	2.4	3	12	205	214	203	216	0.90
5	6	0.00019	0.047	16.2	1.7	3	21	233	251	232	252	0.94
6	6	0.054	13	8.5	5.6	1	23	260	283	260	283	0.95

Coding Sequence: ATGGACCAGCTCAGGCTCAACCTCAACCTGGACTTCAGCGACGCTCAGGTGACATTCGACTCGTTCGAACGTAGCATCCAAAAGCAACGGCCTGCCAACACTACAGCTACTACAAAGACAACGAAGAACAAAAGCACGGATAAAAACGCCAGCGAAAAGTCCTATCCCTGTCCGAACTGCTCGAGTGTGTACAATCGTAGTGACAACCTTACGCAGCATCTCAAGTACGTGTGCTTCCAGAAGCCGAGGTTCAAGTGCCCCTACTGTAACTATGTTACCAAGAGGACCTATAACGTTTACGGTCACGTGCGCAGTAAACATCCAAATGAGAAAGTCGGGTATATAGATTTGGAGGACTCCAATAATCTGGTGACACCACAGGAGTGCGCGCTGCGAAGAAGAACGAGGGATGAACCTACTTATCCTGTGCATCAGTCGTCGAACAACTCCTATGAGGAGAATCTCTTGAACATCCAGCCGAGAAAGAGTTTCGAACGAACTAACGAAATAACAACTTCCAACGTGTGTCCTCAATGCAGCAGGACATACATGTGCTTCTTCAGCCTGAAACGTCATCTCAAATTTGAGTGTAACAAGCCGGCGCGATTTGGCTGCCCTTACTGTAACTATCGGTGTAAACGTTACCTGGCGCAGCCGTACGTCGAGTTTTTCAGGCCCAGTCAGAAAGTTAACTTCTGCGAGCGCTGCGGCAAGTCTTACAAACACGCTCGCAACCTCGATCGTCACCGCAAGCTCGAGTGCGGACTGCAGCCGAGGTTTTGCTGTACCTACTGTCCCTATCGCAGCAAGCACAAGAGCGACACGAGCAAGCACGTCATCAGGGTGCATAACGGCGCCAAGCATGAGTTCTACTTTGACGACAAGTGA
Protein Sequence: MDQLRLNLNLDFSDAQVTFDSFERSIQKQRPANTTATTKTTKNKSTDKNASEKSYPCPNCSSVYNRSDNLTQHLKYVCFQKPRFKCPYCNYVTKRTYNVYGHVRSKHPNEKVGYIDLEDSNNLVTPQECALRRRTRDEPTYPVHQSSNNSYEENLLNIQPRKSFERTNEITTSNVCPQCSRTYMCFFSLKRHLKFECNKPARFGCPYCNYRCKRYLAQPYVEFFRPSQKVNFCERCGKSYKHARNLDRHRKLECGLQPRFCCTYCPYRSKHKSDTSKHVIRVHNGAKHEFYFDDK

Sequence clustering based on sequence similarity using MMseqs2