Basic Information

Insect: Eumacrocentrus americanus
Gene Symbol: topi
Assembly: GCA_018902335.1
Location: JABSMT010046691.1:940-3188[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 0.091 8.3 7.1 2.2 1 20 231 250 231 253 0.80

2 15 0.0074 0.68 10.6 3.7 2 23 260 282 259 282 0.95

3 15 0.0001 0.0095 16.4 0.4 2 20 289 307 288 309 0.92

4 15 5.1e-05 0.0047 17.4 0.8 1 23 316 338 316 338 0.96

5 15 1.1e-06 0.0001 22.6 1.4 1 23 344 366 344 366 0.95

6 15 0.024 2.2 9.0 0.6 2 23 378 399 377 399 0.96

7 15 0.019 1.7 9.3 3.3 1 23 415 437 415 437 0.98

8 15 0.0061 0.57 10.8 0.4 1 23 443 465 443 465 0.98

9 15 0.0064 0.59 10.8 2.3 1 23 475 499 475 499 0.92

10 15 0.041 3.8 8.2 0.0 1 23 538 560 538 560 0.98

11 15 1.9e-06 0.00018 21.9 3.1 1 23 566 588 566 588 0.98

12 15 0.00066 0.06 13.9 0.5 1 23 594 617 594 617 0.97

13 15 0.046 4.3 8.1 0.7 1 23 623 645 623 645 0.89

14 15 5.6e-07 5.1e-05 23.5 0.5 1 23 651 673 651 673 0.99

15 15 1.1e-06 0.0001 22.6 2.5 1 23 679 702 679 702 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	0.091	8.3	7.1	2.2	1	20	231	250	231	253	0.80
2	15	0.0074	0.68	10.6	3.7	2	23	260	282	259	282	0.95
3	15	0.0001	0.0095	16.4	0.4	2	20	289	307	288	309	0.92
4	15	5.1e-05	0.0047	17.4	0.8	1	23	316	338	316	338	0.96
5	15	1.1e-06	0.0001	22.6	1.4	1	23	344	366	344	366	0.95
6	15	0.024	2.2	9.0	0.6	2	23	378	399	377	399	0.96
7	15	0.019	1.7	9.3	3.3	1	23	415	437	415	437	0.98
8	15	0.0061	0.57	10.8	0.4	1	23	443	465	443	465	0.98
9	15	0.0064	0.59	10.8	2.3	1	23	475	499	475	499	0.92
10	15	0.041	3.8	8.2	0.0	1	23	538	560	538	560	0.98
11	15	1.9e-06	0.00018	21.9	3.1	1	23	566	588	566	588	0.98
12	15	0.00066	0.06	13.9	0.5	1	23	594	617	594	617	0.97
13	15	0.046	4.3	8.1	0.7	1	23	623	645	623	645	0.89
14	15	5.6e-07	5.1e-05	23.5	0.5	1	23	651	673	651	673	0.99
15	15	1.1e-06	0.0001	22.6	2.5	1	23	679	702	679	702	0.96

Sequence Information

Coding Sequence: ATGAACTGGGAACCAGTGAGTCCATTGAGTGATATAGAGAATGAAATAAATAATGTTGTACAAGAAGATCCAATGCCTCCATGCGCAGTCATCGATCTAGATTCTAAACCACTAAATACTTCGTCCTCATTGTGTCGATTGTGTGCAGGTCGAACGACTGATCCAATCTACATCTACTCAGAATTCGGAGAATCTTTGCATCTTGCAGATAAAATAAACGCTTGCCTAAGCATCAAGGTTCGAAAGACTGATCTTTTACCCAAACAACTATGTGTTCATTGTGTTGAAAAAATCAATTGGAACAACGCTTTTGATTTACAATGTATTGAAGCCGAAGAAACGTTGTCAATGATCCTAAATGATAATAAAATCAATGAAGTCCAACACAAAATAATTAATAAGGTCTGCGATGATCAAGATCCACTATGTTTAGAAGACCACATGGTAACAATCGTTGAAAATCTCGAAGAAACCTACCAGAATCCAATAGTGATCTCTAGTAGTGACGAGGACAATCTATTGAAGCATCTTCAGCTAGAAAATACAAATAAACTCGAAGGAACATCAGTGATCCCTCAAGACCTAAATAATGGTCTGGAGCAGGACAATGCCTCTATGAATTTCTACAGAAGTAAAGAGTCACCGGACAGCCACAAATACAAGCTGAGTACCCAGAATACTCTTCAACCCTACAAATGTCACATCTGTGACGCGACATTTCCCTTCGAGGAACGTCTGAAGTTTCACGAGCAGTTCCACCAAAGTGCCAAGAGCCTCAACTGTGACATCTGCAAGATAACTTTCAATAAAGAGCAAAAGCTGTTTCATCACTACAAGCGCTATCACTGCGACTCATCCACAATCTCTTGTCTTCAGTGTGGAAAATTCTTTGAAGACCAATCGGAGCTACGTGCTCACGTGTGTCTCGATGGAAAAACACGTCCGCACATCTGCGAAGTCTGTAACAAAGGCTTCACTGATGGCTACACATTGAAACGCCATGTCGTTACTCATCTTCCTGAGAAGCCATTCAAGTGTAATCAGTGTCCGAAGAGTTTTACGCAGAAATCAAGGCTCAATAAACACGTAGCTGGTCATGGGATTATCATAGAGCACTCACAAACCTGCTGGAAGTGTCTGGAGTGTGGCGAGATATTCGCTAGCTGCGAAGAGGCAGGTCATCATTACAAAGTTCATGAGAAAACAATAAGGTTGATTGAAGAATTCTCAGCAACTAAGGTCTACCACTGCGAGTTCTGCAATAGCTTTTTTATCGAAGCTCAGACATTGAAGACTCATCAAAGTACACATAAGGCAGAGAAGTCTTTCAGCTGTAATATTTGTTTAACAGACTTCAAGTCTTATTCAGAAGCAGTTGCCCATTGGAAAAAACATCCTCGTGCATTTAAAATCATGACTGTCTTCATGTGTAATGTTTGCAATAAAGACACGAAGGAGCTGTCTCTTCTCTATAAGCACAAAAGAAAAAGACAGCATTTTACTCCAAGAACATCAACAACTGGAGAGCAGAAGTACATTTGTGAACTCTGCGCCGGTCTTTTCAGTAAAATGGAAGAAATAATAAATCATGAAAGAGAAGCTTGTTCAAAATTTCCCTGTGATATCTGTGGCAGTCTTCTTCCCACTGCAACGTCTTTAGGAGCGCACAAGAGACGTCACAGTGGGCTACGTCCCTACGTTTGCAATATTTGTGGCAAGAGCTATACACAGTCGAGCCACATGTGGACTCACAAGAGATTCCACATGGGCGTCAAGCCCTATGCCTGTGAATTCTGCGATCAGAAATTTACTATTAAACCTGACCTCGCAGATCACACGCGAAAGAAGCACACGAGAGAACGACCTTTCAAGTGTGATGTTTGCAACAAAGCCTTTCTCACTGGCTCTGTTTTCTATCAACATCGACTAATTCATCGTGGCGACAGGAGATACAAGTGCAACCTCTGCGACAAGGCGTTTACCAGGACTGAGGCATTGAATAATCACGTGAAGATTCACACAGGAGAGAAACCACATGCCTGCGATGTCTGTGGAAGGAGTTTCAGACAAAAAGGAGACATGAGGAAGCATAGAAGGACTCAGCACGGCGTCAAGGATGATGAGATGGTGTTCAATGGACAAATCGTTGAGAGCCTCGACGATATTGTTGGAATTATAGATACTTAG
Protein Sequence: MNWEPVSPLSDIENEINNVVQEDPMPPCAVIDLDSKPLNTSSSLCRLCAGRTTDPIYIYSEFGESLHLADKINACLSIKVRKTDLLPKQLCVHCVEKINWNNAFDLQCIEAEETLSMILNDNKINEVQHKIINKVCDDQDPLCLEDHMVTIVENLEETYQNPIVISSSDEDNLLKHLQLENTNKLEGTSVIPQDLNNGLEQDNASMNFYRSKESPDSHKYKLSTQNTLQPYKCHICDATFPFEERLKFHEQFHQSAKSLNCDICKITFNKEQKLFHHYKRYHCDSSTISCLQCGKFFEDQSELRAHVCLDGKTRPHICEVCNKGFTDGYTLKRHVVTHLPEKPFKCNQCPKSFTQKSRLNKHVAGHGIIIEHSQTCWKCLECGEIFASCEEAGHHYKVHEKTIRLIEEFSATKVYHCEFCNSFFIEAQTLKTHQSTHKAEKSFSCNICLTDFKSYSEAVAHWKKHPRAFKIMTVFMCNVCNKDTKELSLLYKHKRKRQHFTPRTSTTGEQKYICELCAGLFSKMEEIINHEREACSKFPCDICGSLLPTATSLGAHKRRHSGLRPYVCNICGKSYTQSSHMWTHKRFHMGVKPYACEFCDQKFTIKPDLADHTRKKHTRERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCNLCDKAFTRTEALNNHVKIHTGEKPHACDVCGRSFRQKGDMRKHRRTQHGVKDDEMVFNGQIVESLDDIVGIIDT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -