Basic Information

Gene Symbol
-
Assembly
GCA_947578425.1
Location
OX387983.1:8571215-8579240[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.027 2.3 9.4 0.1 1 23 193 215 193 215 0.93
2 10 0.097 8.4 7.7 0.0 2 20 243 261 242 263 0.93
3 10 0.00018 0.015 16.3 0.3 3 23 288 308 286 308 0.96
4 10 6.1e-07 5.3e-05 24.1 0.2 1 23 312 334 312 334 0.98
5 10 0.043 3.7 8.8 0.6 1 23 339 362 339 362 0.94
6 10 0.14 12 7.2 0.4 1 23 368 391 368 391 0.92
7 10 6.3e-05 0.0055 17.7 0.7 1 23 398 421 398 421 0.98
8 10 2.2e-05 0.0019 19.1 2.3 1 23 427 449 427 449 0.98
9 10 1.4e-05 0.0012 19.8 2.3 1 23 455 477 455 477 0.97
10 10 1.5e-06 0.00013 22.8 1.0 1 23 483 505 483 505 0.98

Sequence Information

Coding Sequence
ATGGATTCAGAGATAATGGTGGAGGCGTTTCCTTTGCTGGGGATGTGCAATTTGTGTTTAAACGAAGGAGCGGTCAAGAGTATGTTGATTGGGTATAAGCACAATGGAACATCGGAAGTGTATGCTGAGATGCTAATGAAATGCTTTGCAGTCGACGTAGCTCAACTGCAGGTAGGAGACACAAAGCGCCTAATATGCGAGCCGTGCATCAGCAGGCTGCGCGACTGTGTGCTCTTCAAAGATCAGGTGGAGGCGTCGTTCAGCACTCTAGAAACTACTTATAAGTTGCATAAAGAGAAAAATGAATCCGATGGTATTAAAAGAGAAATAACTTTACATTGTAATTTTGGTGATGACTTCCAGCAGGATATTGATGATGAAGACGATGACACCGACGATCCAGATTTAAAACCTTTAGTTATCAAAATGGAACCGGATGAATGCACCAGAAAAACTAGAAGTAAAACTGTGAAAAAAATAACAAAATGCCCCGTGAAGAAATCCCACGATTTCAACGACACGGAGACCATGTTAAAAACCGGATTATTCCCATTCAAAATCCGGAAAAACAGAACTTTCTCTTGCTCTATATGTCCTGAAAAATCAACGAATTTAGACGACATAAAAGTTCATGTAGACGACCATAGTAAGACAAATCTGCATATGGCTTTTAAAAAGATGATATTTTCTAACTCCAACCGGTTCTACAAATCCGGAACGAAATTGAGATGCAAAATATGCACCACAGATGTAGCCACCTATGAAGAACTAAGACAACATGTAGAAAATTGTACTCGCCTAAAATTCTCCAGCCGTAAATGGAATAACCTACCTTTCAAACTCGAAAAAGATCAATTGGACTGCCCAGTTTGCAAGAAAACGTTTTTAAACTATGTCAGTTTAAACACACATATGAATGTTCACTACCCCAACTATATTTGCGAGAATTGTGGCAAGGCTTTTGCGTCAAAAGCTCGTTTAAGAGGTCATATGAGGACCCACGAAGTCGGGAACTTCCCCTGCCGGTATTGCGACGCAACATTCGACAGAGTAACAAAGAGAGAGAACCATGTATCAAAAGACCACAAATCCGGGATAAGATATGCTTGCAAGCGATGTAATATATCTCTGACGTCGTTTTACGCTCGCCAGAAGCATTTAGCCGAGGTCCACAATGAGGAATTGAAACGGTACAAGTGTAAGGCTTGTCCTCAGAGTTATATAACTCCTGGTCATCTATCCAGTCACGTACGGAGAGACCATTTGAACGAAAGGAATCATAAGTGCGACAAATGCGATTTGGCGTTTTATACGAAAAATGCTTTGAAAATGCATATGATTAAACATGATGGTGAAAGAATACACATTTGTCCGGTTTGTCAAAAGTCTTACCAAAGAAAAAAGACTTTAAGAGAGCATTTGAGAATACATAACAATGATAAAAGATTTGTTTGTCCGGTATGTGGGAGAGCCTTTACTCAGAAATGCACTCTTAAAGGGCATTTGAAGGTCCATGACCGGAAACCTGATGTTGATGATCGTGTGGTCCAGCCTCTACATTCTATTTAA
Protein Sequence
MDSEIMVEAFPLLGMCNLCLNEGAVKSMLIGYKHNGTSEVYAEMLMKCFAVDVAQLQVGDTKRLICEPCISRLRDCVLFKDQVEASFSTLETTYKLHKEKNESDGIKREITLHCNFGDDFQQDIDDEDDDTDDPDLKPLVIKMEPDECTRKTRSKTVKKITKCPVKKSHDFNDTETMLKTGLFPFKIRKNRTFSCSICPEKSTNLDDIKVHVDDHSKTNLHMAFKKMIFSNSNRFYKSGTKLRCKICTTDVATYEELRQHVENCTRLKFSSRKWNNLPFKLEKDQLDCPVCKKTFLNYVSLNTHMNVHYPNYICENCGKAFASKARLRGHMRTHEVGNFPCRYCDATFDRVTKRENHVSKDHKSGIRYACKRCNISLTSFYARQKHLAEVHNEELKRYKCKACPQSYITPGHLSSHVRRDHLNERNHKCDKCDLAFYTKNALKMHMIKHDGERIHICPVCQKSYQRKKTLREHLRIHNNDKRFVCPVCGRAFTQKCTLKGHLKVHDRKPDVDDRVVQPLHSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00906417;
90% Identity
iTF_01084522;
80% Identity
-