Basic Information

Insect: Eudonia lacustrata
Gene Symbol: topi
Assembly: GCA_947562085.1
Location: OX387339.1:43339416-43360726[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.021 2.7 9.5 1.3 1 23 255 277 255 277 0.96

2 12 0.0038 0.49 11.8 1.6 3 23 286 306 284 306 0.92

3 12 0.023 2.9 9.4 2.6 1 23 310 332 310 332 0.98

4 12 0.00079 0.1 14.0 0.9 1 23 337 360 337 360 0.98

5 12 0.00046 0.059 14.7 0.2 1 23 364 387 364 387 0.96

6 12 0.0074 0.95 10.9 0.1 3 21 406 424 405 429 0.91

7 12 0.12 16 7.0 0.3 3 23 439 460 439 460 0.94

8 12 0.75 97 4.6 3.1 2 23 480 502 480 502 0.97

9 12 6.5e-06 0.00084 20.5 0.5 1 23 513 535 513 535 0.99

10 12 6.2e-06 0.0008 20.6 1.7 1 23 541 563 541 563 0.99

11 12 0.0074 0.95 10.9 2.5 1 23 569 591 569 591 0.98

12 12 3.3e-05 0.0042 18.3 0.2 1 23 597 620 597 620 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.021	2.7	9.5	1.3	1	23	255	277	255	277	0.96
2	12	0.0038	0.49	11.8	1.6	3	23	286	306	284	306	0.92
3	12	0.023	2.9	9.4	2.6	1	23	310	332	310	332	0.98
4	12	0.00079	0.1	14.0	0.9	1	23	337	360	337	360	0.98
5	12	0.00046	0.059	14.7	0.2	1	23	364	387	364	387	0.96
6	12	0.0074	0.95	10.9	0.1	3	21	406	424	405	429	0.91
7	12	0.12	16	7.0	0.3	3	23	439	460	439	460	0.94
8	12	0.75	97	4.6	3.1	2	23	480	502	480	502	0.97
9	12	6.5e-06	0.00084	20.5	0.5	1	23	513	535	513	535	0.99
10	12	6.2e-06	0.0008	20.6	1.7	1	23	541	563	541	563	0.99
11	12	0.0074	0.95	10.9	2.5	1	23	569	591	569	591	0.98
12	12	3.3e-05	0.0042	18.3	0.2	1	23	597	620	597	620	0.98

Sequence Information

Coding Sequence: ATGTCTCCTACTGATGAGTCTGAGGTGATGCATATTGTGATTGGTCTCAGCGATAACTGCGCTGTTGGTGCAGACTTGATATCCGGCAAGGTCCTGAAACGATACGCTCAGTTCCTGATAACCCTGCAAAGCCTTGAGCATATAGATAGGCTGAATTTAAAATTAGTTTCTAATCTTCATGAATATCAAAGTCTAAATGAAGACTGTGTGTATTATTTTACACATGAAGATGAGGTGATAAAAGAAGTAAAAAATGAACCACAAATTGATGAAAAATACGACATTGAACATGAATCTGAGGCTATCAAAGAGGAAATTATGTTTGACGACACTTTGATACAGTTTGGCAGTGACGACGATGACGAACCGTTATCCTTCCATAAAAGCAATAAAGACAAGAAAGTAAAGAAAAAGACTGAGAAGAAAAGGGGTCGTAAAAAGAAAGAGCTGGAGGATGACAAACAATTGATGGAAGAAATACACAAAGCAGAAGTTGAGGCTTCAGAAGACTTATCAGACTTGCTGCCCATACTCGAGGGGGTGACACAAAAAAGAAAACGCGGGCGACCGAAAAAGAACGAGAATTTATCACCAGCCTTGGAGGAGAAAAACAAGAAACAGCGCCGGACGCGGAACACCGGCGGGGTGAACCCGGAGGACTTCAACCTCGAGGAGTACGTTACTATTGTGGAGCTGTCGCTAGAAGAACAAATGGAAGAGGTGAGGAAACGGCAGCAGACGAGTAACTACCAGAACGCGCCGTTCCAGTGCAACCTGTGCTTCCGCGGCTTCATCGACACGCAGGCGTGGAAGCACCACGTCGGGAAGCACGAAGCGATATCTGGCGACATCGAGTGCATAGTCTGCAAGTTCAGATTCAAAACGAAGCGCACGCTGCAGAAGCACGCGTCCACTCACGAGAAGAAGTATAAGTGCAAGTCCTGCTCCTACGTGTCCAAAACTACAACTCAGGCGAAACAGCACCAAAGATGGCACAAAGGCGTCACCTACAAATGTCAGTACTGTGACGAAATATCTACCAAGTGGACGTCGTACCTTAGCCACGTGCGCATCAAGCACCCGTCAGAGTTCGTCTGCGACGTGTGCGGCTACTCGTACGTCAGCAAGCTGGGGCTCACCATGCACCGCACCATGATGCATAAGGACGTCGCGGAGAAGCAAGCGAACGGGAGCTTGAGTGAGGAAGGGCCGTACTGCGTCGAATGCGACGTCAAGTTCATATCGGAGGAAGCGTATAAACGCCACATGGTCACATCTATAAAACACATTCGAAATACCGACCTTAAGAGCGGGTGCCGCGCGTGTGGGCTGGTGCTGGGGAGCGCGGAGGAGCTGCGCGTGCACCACCGGCGCGAGCACGCGCGCCCGCGCCCGCGCAACTACGGCAAGAAGCCCAGCCTCAGCCAGTTCCCCGCCAAGTGCGAGCACTGTTCGGAAGAGATGTGCAACGCGCGCCAGTACTGGGCACACTTCCGACGCGCACACCCGGACAAGAACTATCCCATACAAAAGGACTATGTCTGCGACGTCTGCGGCAAGAGCTTCCGGGGCAACGCGTTCCTCGTGTATCACAAGCGCACGCACCAGGAGGAACGTGCGTTCAAGTGCTCGCAGTGCCCCAAGGCGTTCTTCAACCGCACCAACCTGCTGATGCACGAGCGCACGCACTCAGACACGCGGCCCTACCCCTGCTCCGTCTGCTTCAAGGCGTTCAAGTGCAAGGGCGCTCTCGACAGGCACTTCCGGAGTCACACCGGCGTGAAGCCGTACGAGTGCGAGGTGTGCGGCAAGGCTTTCGGCCAGTCCAACAGCCGCAAGCTGCACGTGCGCACCGTGCACCTCAAGCAGCCCGCGCCCTACGTGTCGCGCGCGCGTCTCGAGCGCCGCACGCGCGCGCGCGACCCGCCCGCGCACTTCATGTACTGA
Protein Sequence: MSPTDESEVMHIVIGLSDNCAVGADLISGKVLKRYAQFLITLQSLEHIDRLNLKLVSNLHEYQSLNEDCVYYFTHEDEVIKEVKNEPQIDEKYDIEHESEAIKEEIMFDDTLIQFGSDDDDEPLSFHKSNKDKKVKKKTEKKRGRKKKELEDDKQLMEEIHKAEVEASEDLSDLLPILEGVTQKRKRGRPKKNENLSPALEEKNKKQRRTRNTGGVNPEDFNLEEYVTIVELSLEEQMEEVRKRQQTSNYQNAPFQCNLCFRGFIDTQAWKHHVGKHEAISGDIECIVCKFRFKTKRTLQKHASTHEKKYKCKSCSYVSKTTTQAKQHQRWHKGVTYKCQYCDEISTKWTSYLSHVRIKHPSEFVCDVCGYSYVSKLGLTMHRTMMHKDVAEKQANGSLSEEGPYCVECDVKFISEEAYKRHMVTSIKHIRNTDLKSGCRACGLVLGSAEELRVHHRREHARPRPRNYGKKPSLSQFPAKCEHCSEEMCNARQYWAHFRRAHPDKNYPIQKDYVCDVCGKSFRGNAFLVYHKRTHQEERAFKCSQCPKAFFNRTNLLMHERTHSDTRPYPCSVCFKAFKCKGALDRHFRSHTGVKPYECEVCGKAFGQSNSRKLHVRTVHLKQPAPYVSRARLERRTRARDPPAHFMY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00682729;
90% Identity: iTF_00682729;
80% Identity: -