Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3.6e-05 0.01 18.4 0.1 3 23 134 154 133 154 0.97

2 6 3.3e-07 9.1e-05 24.9 1.2 1 23 160 182 160 182 0.99

3 6 2e-06 0.00057 22.4 2.7 1 23 188 210 188 210 0.99

4 6 1.3e-06 0.00037 22.9 2.6 1 23 225 247 225 247 0.98

5 6 3.2e-05 0.009 18.6 0.6 1 23 262 284 262 284 0.98

6 6 1.9e-05 0.0052 19.3 3.1 1 23 299 321 299 321 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3.6e-05	0.01	18.4	0.1	3	23	134	154	133	154	0.97
2	6	3.3e-07	9.1e-05	24.9	1.2	1	23	160	182	160	182	0.99
3	6	2e-06	0.00057	22.4	2.7	1	23	188	210	188	210	0.99
4	6	1.3e-06	0.00037	22.9	2.6	1	23	225	247	225	247	0.98
5	6	3.2e-05	0.009	18.6	0.6	1	23	262	284	262	284	0.98
6	6	1.9e-05	0.0052	19.3	3.1	1	23	299	321	299	321	0.98

Coding Sequence: ATGTTCGAACAGCAGATCAAGGCTGAACCCATGAGTTTTTACACAACACATCCACACGTTCACTCTGGTCCCCCCACAATAGTCCGATCGGATTCCAACCATGCGAGCATCATCAATATGAACCAACACCATCAGTCACATCAGGAGGATTCAAAAGACAGCCTCATACAACATCAAGTACAACATCAACAGGATCTCATGGAACAACACCAACAACAACAAGAAATGCAACAACAAGACGATGAGCTAAGCTTCAAAGGAATGGATGATGAAGGGGTTGATATGGATATGGATGGTCGACAATGTTCTCAGGGTATGGGAGTGGACATGGGATCAGTTCAAACTAAAATGGAAGTGGCGAACGGGGGTCAGTCGGCACCTCGTTCCAAGCCTCAAGCCTGTAAGGTGTGTGGTAAAGTCCTGTCGTCCGCTTCTTCATACTACGTCCACATGAAGCTTCACTCGGGAAACAAACCCTTCCAGTGCACTGTTTGCGACGCAGCTTTTTGCCGCAAGCCGTACCTGGAAGTCCACATGCGTACTCACACTGGGGAGCGCCCCTTTCAATGCGATCTCTGCCTCAAACGTTTCACACAGAAGTCCAGTTTGAACACGCACAAACGTGTCCACACAGatgagcacatgcgcgcgttgatggtgaaggagcggccctacaagtgtgaactctgtcagatgcggttcacgcagagctccagcctcaacagacacaagaaaattcacacggAGGAACACAAACGTGCGCTGCTGGCTAAGgaacggccctaccagtgcggcatctgctttgtgcgattcacccagaaatcaagtttgggccggcacggaaaaatacataccgAGGAGCACAGACGAGCCCTGTTAGAGAAAGTgcggccgtaccagtgccacatctgttttatgcgcttcactcagaagtccagcctgggacgacatgGGAAAATACACACTGGAGAGAGAATGTCTGATGGACAAATAACGTGGCTCAAATTCCCTCATGGTAGTGCTCAGTGCTCAGAGCTCAGCGGTCACTGTGGCCAGGGACAGCTCGGTCTCGGTAGTAACGAGTAG
Protein Sequence: MFEQQIKAEPMSFYTTHPHVHSGPPTIVRSDSNHASIINMNQHHQSHQEDSKDSLIQHQVQHQQDLMEQHQQQQEMQQQDDELSFKGMDDEGVDMDMDGRQCSQGMGVDMGSVQTKMEVANGGQSAPRSKPQACKVCGKVLSSASSYYVHMKLHSGNKPFQCTVCDAAFCRKPYLEVHMRTHTGERPFQCDLCLKRFTQKSSLNTHKRVHTDEHMRALMVKERPYKCELCQMRFTQSSSLNRHKKIHTEEHKRALLAKERPYQCGICFVRFTQKSSLGRHGKIHTEEHRRALLEKVRPYQCHICFMRFTQKSSLGRHGKIHTGERMSDGQITWLKFPHGSAQCSELSGHCGQGQLGLGSNE

Sequence clustering based on sequence similarity using MMseqs2