Basic Information

Gene Symbol
Brd8_1
Assembly
GCA_947086405.1
Location
OX352285.1:3327588-3351162[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.012 0.84 10.7 0.7 1 23 1020 1043 1020 1043 0.97
2 10 0.0016 0.12 13.4 0.4 1 23 1050 1072 1050 1072 0.96
3 10 0.012 0.9 10.6 0.4 2 23 1108 1130 1107 1130 0.93
4 10 7.6e-05 0.0056 17.5 0.5 3 23 1134 1155 1132 1155 0.96
5 10 1.5e-05 0.0011 19.8 1.5 1 23 1161 1183 1161 1183 0.97
6 10 4.9 3.6e+02 2.4 0.3 3 22 1194 1213 1193 1217 0.92
7 10 0.00056 0.041 14.8 3.7 1 23 1222 1245 1222 1245 0.95
8 10 0.0067 0.49 11.4 2.3 1 23 1251 1274 1251 1274 0.97
9 10 0.00051 0.038 14.9 4.7 1 23 1282 1304 1282 1304 0.97
10 10 0.0017 0.13 13.3 0.4 1 23 1310 1333 1310 1333 0.96

Sequence Information

Coding Sequence
ATGGACGAAGAGCTCGAAATTTGTCAGACTTGTCTCAGCAGTGATCGATTTCTATATCCTGTTACAGATGTAAAAGATTTTCTTAGCGTTCTCCAAATTGAGGTTGAAACAAAAACACCAGGCTTCGGTGTATGCTGGGAGTGCAAAAGATTATTTGAGAAGTTCTCCAGCTTCAAAGCTCAAGTTTTAAAAGCACAAGAGCTATTAAGTAGTAATGAAAAGGTGGAAAACCTGAAATCCTTAAGTGCGCTGTCTGCACAAAAAAAGGTCTACCATGATTCATGTCTAGACCCCATTACAAATAATATTCTAGTCACATGCACAGAGACTGGACCAATTTTGATAAAACAAGAGGTGACTGAATGTACAAATGATTGTGAAGCGCATGACACAAGTATTAATGAGCAAAATGTTCTGGAGAGGAATTGTCATGATGAACAGAATACAAAGTCGAATGAAAGTGGATCTCATAATAGGGAAGCAGAAGAGCAAACAAACATAAGCGAACTACCAAGGATAACTCTAGTCGAATCTCTAACAGAAAAGTCGAATGATTCAAACATACTAACTCAGCCTGGTACAGAAATAGAACCACACATAGAACTGAACATTCCCATATCACCCCCAGTCACAGCCCACGAAGATGGAGTTAGTATGCCTTTGGTCAACAGGCTTAATGGAGTAACGGGCAAGGAACATCAGAACAATAGGAGGGAGCATCTGGAAGCAAATGTGGTAGCGAATAGTAAAAATACTCATGTAGGCAAGGAAGTATTAACAAATATGGAATCTATAATGGTAAAAGTGGTGTACAAGGATTATGAGACAGAAGTGCATGGGGTCAGAATAAAGGAGGAGCCAGCGTCTGAACCTGAGGATATGGATGACCCTATCACGTTAAACCATACAGAAGAGACGAGAGAAAATACAGTCGTAAATTCCAATTCTACTGTGTCTGTAAGCGAGATGAAGCAGGAGGCACAAACTTCAGATGAAGTGCTGGAACATAGACTGTGGAAGAAATCTGTCTTGCTTGTGTACAACAGGATCCGCGGGCACAGGTACGCGTCTCGGTTCCTCCGCCCCGTGACTGACGCCGTCGCGCCGGAGTACAGCCAGGTGGTCAGGGAGCCGATGGACCTCGGCACCATCAAGAAGAAAATTGATGGCGGCCTCATCAGGACTACGGCGGAGTTCCAGCGCGACATGCTTCTAATGCTTTCCAACGCCCTAATGTACAACAGTAGTGATCATTACATCTACGACATGACAAAGGATCTGCTCGAAGAGGTAAAATACCAACTAGGTCTTCTACTGACGGTACACGCTCACTCTGTACTGCCTAATGACGCACCTGTCACTCGCCCGCGGCGTCGCTTGGACATCGATTTTCTATCCCCACCTGCTAAACGACCTAGAATATCTACTGCTAAACCTACAATTATAAGACCAACTCTCACACCTAGAACTAAAAAGAAAGCTAAGAAAATTAGACCTAAAGTTGAAAGAAAGTCTGTAGCAGCCAAAGTTACTCCGAAACGAATTAGGCCGAAACAGGAAAGAAAATCTACTGTGACTAAAGTTAAAGCTAAGAAAATAACACCCAAAGTTGAAAGAAAATCGATTGCTAGCAAAGCTGCTCCTAAAAAAATAGTACAAAATAAAAGAAAGTCCGTAAGTGGTAAAGTAGCAAAAAAAATTAAAGCAGAGAGGAAATCTATTGCTTGCTCTGCGATCGAAAACGTAACTCCAACACCGGAGGTGAAAATGGAAGGCAGGAGAAAGTCTACAAGAATTCGAACAATCAAAAGATATTCTCCATGCTTTCTACCAAATCCCGTTAAAACAAGCAAAGTCAGTAAAAAACAGCATATATCAACTCTGAAGTCGGAATTTAAATCAACAGGTACTGATATGGTACCTATTGTACCTCAGACTGGGAAAAAACGTGGCAGGAAACCAAAGGCAGACAGCTATATGGACGATGTTATAACTGGGTCGGAGGTAAACATGAATGATTATTGTGTTGCAATAACGACAGAACCGCAAAGAGATCTAAGTAGAGACGAAGCGAGCTATGTAAAGAAAGTATTGGAAGAAAAAATCTTAAATCTAGCTTTGGATTTTAGCCAATTTGCGCCAAGATTTAGAGGGAAACCTGTTATAGCTGACGGTGTAGTAAAACTCTGGTGCGATGATCAGAAATCTCTAATCTGGCTAATACAAACCATATCTAATTTTCCAAAGAAAGTTGGCAAGTTTGTTGTTAGAAACCAGACAGATTTGCCTAAGAAAATAAAGTCTGCAATTGTTGTACCAGGGTTTAACGGTGAAGTGGAAGTTATATTAAAATTGCTTAGAGCGCAAAATCCTTGGGCTCAAGTGGAGTCCTGGGCAGTGTACAGTGCAGAACAGAGAGGTGAGAGCATGATTCTACTGCTAGGCATACCAGATACGTTAAATGCTGTGAAAGGTGGTGTTTGCTGGGAGTGCCGCAGTGTTATGACAAGGTTCACAAGGTTTAGAACACAGGTGCTACAAGCACAGAACTTGATATGTCAGTGTAATAAGCTACAAGAACTAAAATGTTTAAGTAAACTATCATACAATACAAATTGCTACTACAATTATGAATTTTCCTACAACCTGGATTCCCTAACCAATTCCAAAGATGTTAAAATCAAAGAAGAAATAGATATGTCTGATATTTATGAAGAAACTTTTAATAATGATGATGAAAAACAATATTTAACAGAAATTGAGGAAAGAGTAAATGATATTGAAGAACTACTCAACGATTGTGATGAAAAACCATTAACAATAGACACTAGCGATATGTATGTTGAAATTTTAAATTCAGAAACAAAACTAAACTTAAATAAAATAAGAAGAGTCGCACCAAAGAGGTTTAAAAACAGTAGAACACCAAAAATAGGAGATACTGATACAGAAGAAGAAGAATTAAGACATAAATTTACAACTGTTGTATTCACAGAAGAAGAGATGTTAAGAAATAGGGAAGAGAAGAGAAATCAGCCAAATTTCAAGAAAATACCGTATAAGTGTGATTCGTGTGTTTTAGGGTTTACAAGAAATGATACATATGATGTACATATGGAGAAAAAGCATGATATGAATATCGGCGACTACCTCTGCCCAGTCTGTCAAATCCGCTTCCCGAACGAGAAGCTAGTCGAACGCCATAAGCGGAAACACTATGTCTGTTACCGGTGTCGTCTGTGCAAGTATGAAACCCTGGAGCTGTGGTCAGCACTCAGCCACTGTCGCCTGAAGCACGTCGGTGACTCCAGGGAAAGCATACACTGTCCCTACTGCACTACTGTCGCCAAAACAAAAGAGGAGCTTTCACAGCACATTGGTTCTCAGCATGGTGTCATTTGCAACGAATGCGGGGAGAAGTTCAAAGGGTTAAGTACCCTGAAGTCACATAAACGACGAATCCACGGCGTGAAACGAGAATTCATTTGCGACATGTGCAGCAAGACGTTCAAGACTAAATCCCGCCTGGAGTCCCACATGGTGTCTCACAACTCGACGCTGGCGCAGTCGCTGGCGTACTGCGCGGTGTGCCGGGTGCAGTACAAGAACATATACGTGTACAGAAATCATTTAAGGACAAGCGCCAACCATGCAGATCAGGCATATCAGTGTCGGGATTGCAACAAGAAATTCGCCTCGAAGGTTTACTGGAAGAAACACTACAACTTCTACCATCTGCATAAGTCCCAGTTTCACTGCGAAATTTGCAATAAGCTATTCATCTCGGAGTGGCGGCTGAGGAGTCACAGACAGACGCAGCACGGGCTGAGCCGGTCACGTGACCACCACTGCAACGTGTGCGGCAAGCAGTTCTTTACGTTGTCCACGCTCAAAGGCCACCAGCTAACGCACTCTGAGCAGAGAACTTTCATGTGCGAGGATTGCGGCGACACTTTCAAGCAACGGCCGGCCCTGTACACTCATTATAAACTAGTACACAAAGGCATAAAACGCAGGAAGAAACTGTAA
Protein Sequence
MDEELEICQTCLSSDRFLYPVTDVKDFLSVLQIEVETKTPGFGVCWECKRLFEKFSSFKAQVLKAQELLSSNEKVENLKSLSALSAQKKVYHDSCLDPITNNILVTCTETGPILIKQEVTECTNDCEAHDTSINEQNVLERNCHDEQNTKSNESGSHNREAEEQTNISELPRITLVESLTEKSNDSNILTQPGTEIEPHIELNIPISPPVTAHEDGVSMPLVNRLNGVTGKEHQNNRREHLEANVVANSKNTHVGKEVLTNMESIMVKVVYKDYETEVHGVRIKEEPASEPEDMDDPITLNHTEETRENTVVNSNSTVSVSEMKQEAQTSDEVLEHRLWKKSVLLVYNRIRGHRYASRFLRPVTDAVAPEYSQVVREPMDLGTIKKKIDGGLIRTTAEFQRDMLLMLSNALMYNSSDHYIYDMTKDLLEEVKYQLGLLLTVHAHSVLPNDAPVTRPRRRLDIDFLSPPAKRPRISTAKPTIIRPTLTPRTKKKAKKIRPKVERKSVAAKVTPKRIRPKQERKSTVTKVKAKKITPKVERKSIASKAAPKKIVQNKRKSVSGKVAKKIKAERKSIACSAIENVTPTPEVKMEGRRKSTRIRTIKRYSPCFLPNPVKTSKVSKKQHISTLKSEFKSTGTDMVPIVPQTGKKRGRKPKADSYMDDVITGSEVNMNDYCVAITTEPQRDLSRDEASYVKKVLEEKILNLALDFSQFAPRFRGKPVIADGVVKLWCDDQKSLIWLIQTISNFPKKVGKFVVRNQTDLPKKIKSAIVVPGFNGEVEVILKLLRAQNPWAQVESWAVYSAEQRGESMILLLGIPDTLNAVKGGVCWECRSVMTRFTRFRTQVLQAQNLICQCNKLQELKCLSKLSYNTNCYYNYEFSYNLDSLTNSKDVKIKEEIDMSDIYEETFNNDDEKQYLTEIEERVNDIEELLNDCDEKPLTIDTSDMYVEILNSETKLNLNKIRRVAPKRFKNSRTPKIGDTDTEEEELRHKFTTVVFTEEEMLRNREEKRNQPNFKKIPYKCDSCVLGFTRNDTYDVHMEKKHDMNIGDYLCPVCQIRFPNEKLVERHKRKHYVCYRCRLCKYETLELWSALSHCRLKHVGDSRESIHCPYCTTVAKTKEELSQHIGSQHGVICNECGEKFKGLSTLKSHKRRIHGVKREFICDMCSKTFKTKSRLESHMVSHNSTLAQSLAYCAVCRVQYKNIYVYRNHLRTSANHADQAYQCRDCNKKFASKVYWKKHYNFYHLHKSQFHCEICNKLFISEWRLRSHRQTQHGLSRSRDHHCNVCGKQFFTLSTLKGHQLTHSEQRTFMCEDCGDTFKQRPALYTHYKLVHKGIKRRKKL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-