Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.6 36 5.1 1.5 1 23 85 108 85 108 0.91

2 7 1.6 97 3.8 0.1 6 23 138 156 135 156 0.88

3 7 0.035 2.1 9.0 0.4 2 23 179 200 178 200 0.97

4 7 6.2e-05 0.0037 17.7 0.2 1 23 204 226 204 226 0.97

5 7 7.1e-05 0.0042 17.5 1.8 1 23 231 254 231 254 0.97

6 7 0.22 13 6.5 0.7 2 13 262 273 261 284 0.83

7 7 1.4e-05 0.00085 19.7 1.2 2 23 292 314 291 314 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.6	36	5.1	1.5	1	23	85	108	85	108	0.91
2	7	1.6	97	3.8	0.1	6	23	138	156	135	156	0.88
3	7	0.035	2.1	9.0	0.4	2	23	179	200	178	200	0.97
4	7	6.2e-05	0.0037	17.7	0.2	1	23	204	226	204	226	0.97
5	7	7.1e-05	0.0042	17.5	1.8	1	23	231	254	231	254	0.97
6	7	0.22	13	6.5	0.7	2	13	262	273	261	284	0.83
7	7	1.4e-05	0.00085	19.7	1.2	2	23	292	314	291	314	0.96

Coding Sequence: ATGCTTTACGATGGGTTAAGAGGCTGGCGGCAAGGTACGGTACTAGGTGAGCCGACACCACGACGTGTTGTAGTGGACCGAAAGAAAAAGGTACAGAAAATCGTCATAACCCGGCATCAAAACAACCCTGACCAAGTGAAAATTCAGTTCATGCGCAAGAAGGGAGAGGTCGACAAGCACTTGCACAACCTCAGAGAGATTCTGCTCAGCTCGAACGCAACCCCCATTCGCAGGGCCCAACTCGGCAACGGCTACAGATGCTGCTACTGTGTCAACAACTACGCAGAACCGAAAACCTTGAAAGAACACTCCATCAACGATCACGACGAAACAACCAAAGCTTCCTACTTAACCGGCACCATGATGCCAAAATTCATGGTCAGATTGGACATAACCAACCTCAAATGCAATTGCGACGCCGATGTCGAAAGCTTGGAACAATTGATGACGCATTTGCGTGAAGAACACAAAAAAGTTCTGTATACCGATATCAAGCCGCATATCGTTCCTTTTAGGTTCGACAGCGACTCACAAAAGTGCGTATATTGCAGTTACGTGTCGAACAACTTCAAACTCATGGTCGAACACATGAATGTGCATTACAATAACTTCGTCTGTAAGGTCTGCGACGCTGGCTTCGTGAACAGTGATAAGCTCACGTCGCACGCGTCAAAACACAAAATTGGCGAGTTCCGATGTAGTTATTGCTCGAAAGCATTCGATACGCGAGTCAAAATGAAGTCGCACGAACGTTCAATCCATGTTTATATGAGTAAGAGAAGCAAATGCTCGTTTTGCGGCGAAAAGTTCAAGGACTACGTGATTAAGAAACAACATGAGGCGAAAATACATGGTGCTGCGCAGGTGGTGTTGCAGTGTAAAGCGTGCGATAGAACATTTGACAATCAACGCGCGCTGTCGAAACATTTGAAGACTTATCATCTAATGGAACGCAATAAATAG
Protein Sequence: MLYDGLRGWRQGTVLGEPTPRRVVVDRKKKVQKIVITRHQNNPDQVKIQFMRKKGEVDKHLHNLREILLSSNATPIRRAQLGNGYRCCYCVNNYAEPKTLKEHSINDHDETTKASYLTGTMMPKFMVRLDITNLKCNCDADVESLEQLMTHLREEHKKVLYTDIKPHIVPFRFDSDSQKCVYCSYVSNNFKLMVEHMNVHYNNFVCKVCDAGFVNSDKLTSHASKHKIGEFRCSYCSKAFDTRVKMKSHERSIHVYMSKRSKCSFCGEKFKDYVIKKQHEAKIHGAAQVVLQCKACDRTFDNQRALSKHLKTYHLMERNK

Sequence clustering based on sequence similarity using MMseqs2