Basic Information

Gene Symbol
Hsf
Assembly
GCA_013282895.1
Location
scaffold:35421898-35430169[-]

Transcription Factor Domain

TF Family
HSF
Domain
HSF_DNA-bind domain
PFAM
PF00447
TF Group
Helix-turn-helix
Description
Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 4.8e-34 1.3e-29 103.2 1.0 1 100 15 113 15 113 0.93
2 3 0.48 1.3e+04 -2.7 0.1 70 88 218 236 202 239 0.68
3 3 0.23 6.5e+03 -1.7 0.0 45 65 362 382 349 405 0.82

Sequence Information

Coding Sequence
ATGCCTGATGGTAATCCTGCAAATGATCAACGGATAGCCTTATTTTTACGAAAACTTTGGACTTTGGTTAATAGTCAAGAGACTGATAATGTCATTACTTGGAGTGAGGATGGTGACAGTTTTATTATAAAAAACCAAGTAGAATTCTGTGAAGTTTTACCTAGATACTTCAAGCATAATAACTTTATGAGTTTTGTACGGCAGTTACACTTATATGGTTTTAATAAAAGAATATCTGATATTGATCATACATCTAATCATAATGGAACGTTATGTGAATATGCACATCCATACTTTATGAAAGAACATCCTTGTTTATTATTATCAATTAAGCAAAAGAGAGGGGAAAAAGTGCAACCAAGCATAAAACATGATATTGATTCAATTGACACAATAAATACACTAATAAAAGAAGTAAATACAGTAAAAGACAAAAATAAAATGCTCGATTCTAAATTTATGGCTATGAAACATGAAAATGAGTGTTTATGGCGTGAATTAGCAGTTATCCGCCAAAAGCATATGAAACAACAAAGGATTTTAAATCAGTTAATCCAATTCTTAGTTACTTTAAGACAACCTGGCACAAATAATACATTGTGTCGAGAAGTTAAAAATAATGTTAGATATGTTCTCCCTATTATGCATCACAAAACATCAGAAAAGGCAAATTCGAGTGAAACATTTACTAATCCAAAATATAAACAGTCTACTTCATATGGACCTGTGATACATGAGTTAGATGCTGCCGATATCTTGAATTCAAATGATGTTCGTAAAAGTCATAAAGAAATTCTAAATGAAGTAGTAGAGTCTGAAGGTGTGGTCCTTAGTCCTAGCAGTACATCTAAAATGTTTAATAGTCCTAGTGGTTCAACAGTTGAAGATTTTTTCCCATCTAATGAAATCATAATAAATTCACCATTAGATGATTTGATTAGAGAAGTATCAGTATCACCTACTGAAGAATTATTAGAACCAAAGTCAACTGTAGTCACAGTTTCTTCATCAAAACCAGAAAAGAAAATTGATAAACTAATTAAGAACTCAAATACAAAGAGAGGTAAAAAGGATATTAACCCCAAAAAGAAGAAAGTGAAGTCAAATTTGGACGATACAAATATTTATCAATTTAAACCAGTGATTTCTGACAAGCCTTATGTGATTAAAGTAGAACCATCGGGGGATGATCCACCAGTTATTTCTATTCCGGACGTGGATTTCGTTGAGCCTGAAATCAGGGAAGCTGTCACTAAACAAATTGATACGGTTCAAACAGAATTAGAAAATTTATTGAAAGGATTAAATGATAAGTTTACATTCGATGCAAATATGTTTCTTAATTATATTAATGATGACCCAACAAATTTAAATTTACCTATTAAGACAGAAGAACAGTCTCTTAATGATGCAAAAAATGGATTGAATGTTACACCAGACAATCAAATTGTTTCATGTCTATCACCAAACACATACGATCTAAATGATCTAATGACTGCTTCGGATGACTGGACAATACCAAATACACCCATGTCTTTTGATTCATCAATTGAAAATTATACTTTAGATACTCCAGTTGTAACTGATTCTTTATTAAATTCTGACTCACTTTTTCCAAATACAATCATATCTGATCCTCCTATAAAATAG
Protein Sequence
MPDGNPANDQRIALFLRKLWTLVNSQETDNVITWSEDGDSFIIKNQVEFCEVLPRYFKHNNFMSFVRQLHLYGFNKRISDIDHTSNHNGTLCEYAHPYFMKEHPCLLLSIKQKRGEKVQPSIKHDIDSIDTINTLIKEVNTVKDKNKMLDSKFMAMKHENECLWRELAVIRQKHMKQQRILNQLIQFLVTLRQPGTNNTLCREVKNNVRYVLPIMHHKTSEKANSSETFTNPKYKQSTSYGPVIHELDAADILNSNDVRKSHKEILNEVVESEGVVLSPSSTSKMFNSPSGSTVEDFFPSNEIIINSPLDDLIREVSVSPTEELLEPKSTVVTVSSSKPEKKIDKLIKNSNTKRGKKDINPKKKKVKSNLDDTNIYQFKPVISDKPYVIKVEPSGDDPPVISIPDVDFVEPEIREAVTKQIDTVQTELENLLKGLNDKFTFDANMFLNYINDDPTNLNLPIKTEEQSLNDAKNGLNVTPDNQIVSCLSPNTYDLNDLMTASDDWTIPNTPMSFDSSIENYTLDTPVVTDSLLNSDSLFPNTIISDPPIK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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