Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.52 92 4.7 0.2 2 8 109 115 108 119 0.89

2 6 2.2e-06 0.00039 21.6 3.5 1 23 193 215 193 215 0.98

3 6 2.1e-06 0.00038 21.7 1.7 3 23 223 243 221 243 0.98

4 6 2.1e-06 0.00038 21.6 1.4 1 23 247 269 247 269 0.98

5 6 0.0015 0.28 12.6 1.6 1 23 285 307 285 307 0.98

6 6 5.7e-06 0.001 20.3 4.0 1 23 313 335 313 335 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.52	92	4.7	0.2	2	8	109	115	108	119	0.89
2	6	2.2e-06	0.00039	21.6	3.5	1	23	193	215	193	215	0.98
3	6	2.1e-06	0.00038	21.7	1.7	3	23	223	243	221	243	0.98
4	6	2.1e-06	0.00038	21.6	1.4	1	23	247	269	247	269	0.98
5	6	0.0015	0.28	12.6	1.6	1	23	285	307	285	307	0.98
6	6	5.7e-06	0.001	20.3	4.0	1	23	313	335	313	335	0.98

Coding Sequence: ATGCATAAACTCGAAGAAATTTACTGGGAGGAACAGTTGATTGACGATATTGagTTGGAGGATCGATCCGTTGAGACAACTATTCGAGGAATCCGCCTAGAAGCTGACAGCCGTTGTAATTTTCCTGTGTCCAATAATCTAAGAGATAGTTTAACCATAAGACCAATAACGAAGACGATTGTATCTAGTCATGGTGACGCTGTTTATGATAATGGATCGATCACTGGTTCAACACCGAATGTTTCTAATATGTACCTCGATAATATTGAAATGCATTCGATTTTCACGCCAGACAAACAGACGAAACCGAAAGAAATTTTTACTCAGTGTCATATTTGTGGAAAGTACGTGATCGTTCAGATGTGTCCCGAGACCGGCGTTTACTCTAAATGCAGATATTGTTTTAATTCACCATTTAGTAACCCGGACgatgttatttttgaaaatctcaaTGTTCTACCAGATGGTATTGAGCCAGAGGTCACAATTACGACGATGGATCTCAACGTTCCTAGAGATGTTCAACCAACCTATTTAACAGCCAGCGGTACTAGCCATTCGAAATCTGACGGATCTTTCAAATGTGAGCACTGCGGTAAATTATTCACTCGAAATTGGTACCTAAAACAGCACGTGAAACTGCATTCGAACGATAAACCATTCGGTTGCGACATGTGTGATAAACGTTTCTTGAACAGTTCGAATTTGAAACAGCACATGAAAACGCATTCTGTTGAATATCGATGCCATGTATGTAACAAAACCTATATCAGTCAGGCGTTATTGAATGAACATCTGATTAAGCATAGCGACGCAGACAtcaaaattccagaaaatttacGAATGCTACGATTTCAGTGTAGTTATTGTAACCAAGGCTTCGACGAAGAAAATCGTTTTAAAGAGCACCTCAAAAGTCATACTAAGGAACTACCATATCATTGCGATAAGTGCGATAAAGCTTTTCGATATAATAATTCATTGCTAAAACACAGAAAAGTGCACGATTTCGAGTGTGAAGAAGCGCTTAATTTGACCAAAACCAAATCTTAG
Protein Sequence: MHKLEEIYWEEQLIDDIELEDRSVETTIRGIRLEADSRCNFPVSNNLRDSLTIRPITKTIVSSHGDAVYDNGSITGSTPNVSNMYLDNIEMHSIFTPDKQTKPKEIFTQCHICGKYVIVQMCPETGVYSKCRYCFNSPFSNPDDVIFENLNVLPDGIEPEVTITTMDLNVPRDVQPTYLTASGTSHSKSDGSFKCEHCGKLFTRNWYLKQHVKLHSNDKPFGCDMCDKRFLNSSNLKQHMKTHSVEYRCHVCNKTYISQALLNEHLIKHSDADIKIPENLRMLRFQCSYCNQGFDEENRFKEHLKSHTKELPYHCDKCDKAFRYNNSLLKHRKVHDFECEEALNLTKTKS*

Sequence clustering based on sequence similarity using MMseqs2