Basic Information

Gene Symbol
THAP1
Assembly
GCA_951394125.1
Location
OX596030.1:4144438-4146823[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.29 27 6.0 1.8 1 23 420 443 420 443 0.94
2 8 0.0003 0.028 15.4 2.1 2 23 479 501 478 501 0.94
3 8 0.023 2.2 9.4 0.3 2 21 514 533 514 534 0.93
4 8 0.036 3.3 8.9 0.1 3 20 609 626 608 628 0.94
5 8 9.5 8.8e+02 1.2 1.2 3 20 644 661 643 662 0.93
6 8 3.4e-06 0.00032 21.5 1.2 1 23 669 691 669 691 0.98
7 8 0.00016 0.015 16.2 6.6 1 23 697 720 697 720 0.96
8 8 1.7 1.6e+02 3.6 0.1 1 15 726 740 726 743 0.82

Sequence Information

Coding Sequence
ATGCCCTCATTTTGTGTAATTTCAAATTGCCAAGATAAATATAAACACTCGGAAAATGTATCATTTCACAAATTTCCTCACAGTCGTAAGGATCTTCTCGAAAAGTGGATTGAGTTTGCTAGTCGTGAACCAGATTGGAAACCATCCAAATGGAGTGCAATATGTAGTCGGCACTTTGCCTCTGATGATTTTCGCAATGTTAATTCCAGAAAATCACTTAAGAAGACTGCAGTTCCAACAATAAAAACCACCTCATGGAATGAGCACACTGAACAATTGCCACCATCTCTATCGCTTCATAATCTTGAAGCAGAATTGAAGATCCCTGAAAGTAGTTGTCGTCTTTGCGGGATCTGTTGCCGTCCAGTAGCAACATTTGCcacgaattttgaaatttttggtaTGATACAGAAATGCTTCCCTACACTCAATATCCAACTGGATGACAATTTACCAAAAGATATGTGTTCGGGCTGTTTAAAAAGACTCAACAGCTTTTCTGAGTTCATCGACTTAGTTCTAAATACTCAAAAGCACCTCCATGGCACGAttcgaattgaaaaattcataaaaccaCCAGAAAGACAACTAAAAATTAAACAGGAACCAGTCGTGAATGTTAAACAAGAAGTAGCCGAACACTTCGATAGCTTCCTGAGCGACGAGCTTGAAGAAGAACAGGACTGTGAGCAGAAATTCTCCTTCTGTGATTTTCCCATGCTTAACACACAAGATATTATAAACAATTGTGACATCATGGAAATTATTAACCTTGATGATCCCTTCATCGACATACCGGATGATGAAAATGGCAACGAAATTGGAGAAATGGTAAATCAGGACTTTTTCACAGCTACGAGTAAAACGCAGTTACCTTCGAAACTGGACTCCATTAACTTAGTGCATGAGCACAACTACGCCATGCCAATCGAATGCAAAGAATCCATCAACCTCACAAACGTATATAAGACTGAAAAGACGGAAGACAAGGATGACCATGACGTGGTGGCTAGCAACTTCCCGCCGGACACTTTAATCACTGCTAAGCCGAAATTCTGCAACAGTACAGAGTCTACAATCATCAACAATGATTTACAATTCTCACACACTCCATCTTCATCATCGTCCGGTGGAAAGCTGATGGTGACATCAGTAAGCGATTTGCTGCCGCGACCAAAAGTCGAGACGAACATTAAGAAGCCAAATATTGTAGTTCTGAATGAAAGCATTGTGAAGACGGCATCTGCGTTTCAGCTCCATCCTTGCTCCATGTGCCAATCGCAATTCTTCTCCGCTGAGGGTTTGAGTCACCATGTTGCAAAAACGCATTTCCCAATGGTTACGTTGCCCCCAAACATTGCTTCCACTTCAATTCCGATGCCATCATGCAATGTTTCGGAGCAGGTCATTCCTCAAGTTGATACCAAGTCCATATACTGTCCCTTTTGTTCCAAAAGTTTTTCCAATATTCATGATCTCCTCAAGCACAAGATCAAAAGTCACCCCAAGCCAATTGGTAGAAGGAAAAAACGTGGCCGCGAGTGTTCTGCTTGTGAAAAGTTCTTCGTTAGCCAAATGGGATTAAAGAACCATCGTAATTACGTATGTTTATCAAAAGTAAATTCATCCCAGAAGACCTTCAAGTGTCGTTTGTGTTCCAAAGATACGTTCAAACATTGGAGAATTTACAGAAATCATGCATCACGCTGCAAGATTAGAAGCTCAAAAAAACCTgcgaaaatggaaaaaattccAAAGGTTCTTTCAAAAGACAAACCAAAAGTTTCCCAAAAACCGTCAGCAAAAGATATTTTCAACCTTCTCTGCCTTGGTTGTAATCAGACATTCAGTTCGGTTGATGATTTTCGTTTGCATTACATTGAAGATAAGTGCAAACTTCAACCATCAGCCGATCAGGTGCTTGCATTCTGCCGCACTTGTAATCGACCGATTACCAAATTCGCTAAATTGCGTATTCATCGGCATTTTCAGTATTCCTCGAAGTATTACTGTAAGCAATGTCCGAAAGCATTTAAGAACTCAAAGCTTCTAGCTCAGCACCGTATCACACATTCGAATGTACGGAAACATAAATGCCATTTATGCGAGAAGACATTCAAACGAAATTGCGGCTTACAGCAGCATATAAAAGCGATTCATTTGAAACTGAAACCACACGAGTGTGTTGTGTGTAAGAGACGGTTTGCTCTCAAAGGAGATATGTTACGTTGTAAACATTCAATATTGGCACTGCAATAG
Protein Sequence
MPSFCVISNCQDKYKHSENVSFHKFPHSRKDLLEKWIEFASREPDWKPSKWSAICSRHFASDDFRNVNSRKSLKKTAVPTIKTTSWNEHTEQLPPSLSLHNLEAELKIPESSCRLCGICCRPVATFATNFEIFGMIQKCFPTLNIQLDDNLPKDMCSGCLKRLNSFSEFIDLVLNTQKHLHGTIRIEKFIKPPERQLKIKQEPVVNVKQEVAEHFDSFLSDELEEEQDCEQKFSFCDFPMLNTQDIINNCDIMEIINLDDPFIDIPDDENGNEIGEMVNQDFFTATSKTQLPSKLDSINLVHEHNYAMPIECKESINLTNVYKTEKTEDKDDHDVVASNFPPDTLITAKPKFCNSTESTIINNDLQFSHTPSSSSSGGKLMVTSVSDLLPRPKVETNIKKPNIVVLNESIVKTASAFQLHPCSMCQSQFFSAEGLSHHVAKTHFPMVTLPPNIASTSIPMPSCNVSEQVIPQVDTKSIYCPFCSKSFSNIHDLLKHKIKSHPKPIGRRKKRGRECSACEKFFVSQMGLKNHRNYVCLSKVNSSQKTFKCRLCSKDTFKHWRIYRNHASRCKIRSSKKPAKMEKIPKVLSKDKPKVSQKPSAKDIFNLLCLGCNQTFSSVDDFRLHYIEDKCKLQPSADQVLAFCRTCNRPITKFAKLRIHRHFQYSSKYYCKQCPKAFKNSKLLAQHRITHSNVRKHKCHLCEKTFKRNCGLQQHIKAIHLKLKPHECVVCKRRFALKGDMLRCKHSILALQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00427716;
90% Identity
iTF_00427716;
80% Identity
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