Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 5 3.4e+02 2.8 0.6 2 19 174 191 173 196 0.90

2 6 0.99 67 5.0 4.7 1 14 203 216 203 222 0.86

3 6 0.00015 0.01 17.0 2.3 1 23 233 255 233 255 0.98

4 6 0.00014 0.0092 17.1 1.6 1 23 268 290 268 290 0.98

5 6 4e-06 0.00027 21.9 0.4 2 23 298 319 297 319 0.96

6 6 3.4e-05 0.0023 19.0 0.8 1 21 325 345 325 346 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	5	3.4e+02	2.8	0.6	2	19	174	191	173	196	0.90
2	6	0.99	67	5.0	4.7	1	14	203	216	203	222	0.86
3	6	0.00015	0.01	17.0	2.3	1	23	233	255	233	255	0.98
4	6	0.00014	0.0092	17.1	1.6	1	23	268	290	268	290	0.98
5	6	4e-06	0.00027	21.9	0.4	2	23	298	319	297	319	0.96
6	6	3.4e-05	0.0023	19.0	0.8	1	21	325	345	325	346	0.95

Coding Sequence: ATGTCCTGGAAAACCGTAACACCAAATAGTGATATGTACACATACGAATACTTCCTGACGGAATACGTTTGCAGAATATGCTGGTGCCAGAATGGAGTGAAGGAAATAACTTCGGATGTCCCTGAAGATGTTGAAACGAACCTTACTATTCCTGAAAAATTATTAGAATACATCGGTGTTGATCTGACTGTCAACCCGCGACCCACGAAAATCTGTCCTAGTTGCTGGAAAGAAGTTGAAAACATCAGTGAATTCAGAAGTTTTTGTCTTACAACTCAAAGAAAATTGTACGATATACTCCAAAAAGGTCCGCAGATGCCAATACAATCAGATCAGAAACTAGTTGTAGAAGAAAATAATTCAATTGAAGATTACAGACCTAGTAATTCCAATGAATTTGATTTGGAACTCGCAAACACAATAAACAACCTCTTTGAAGATTTGAATAACGAATCGGATGGTAGAGATGAACCGTCCCCAAAAAAgcccaaaaaaacaaaaaagctaAGGTCTGAAACATACTGTACATCATGTAAAACTGATTTGGGGTCTCAAGATTCATTTAAACAACATAATGTAGACATACACAGCTTGGAAAATGGttgttttaaatgttttggCTGCAATAGACCTTTTAAACATAGAAAGCGTTGCCTGAGGCATGAGACAGATTATTGTAAAGCTCTTAAAAAAGGTTACAAATGTGGAATTTGCAAAAAGTTTCTACAGAAAAGGAGTAATTTTGAGAAACATTTAAGGGcacataaagaaaacaaaaatttgGATTTGCCAGAAGAACTATTTCAATGTAAAAAATGTGTGAAACAATATACGAGCATGGAGTCATTGAATGAGCACATGACAATGCATGAAAAGGATAGGAATAATTGGGTCTGCGATACGTGTGGGCGTGTGTTTTCGAGACGAGACTACCTTTACAAACACAAGTTGATACATGAGGGGACCAAACAGCATGTATGTCCGCACTGTGGCTTCAGGACCATACAGAAGTCATCTCTCAATGTTCACATCAGGTACAACGCGCCAGCTGTCTTACACATGAATCAGccgcatttattattattatga
Protein Sequence: MSWKTVTPNSDMYTYEYFLTEYVCRICWCQNGVKEITSDVPEDVETNLTIPEKLLEYIGVDLTVNPRPTKICPSCWKEVENISEFRSFCLTTQRKLYDILQKGPQMPIQSDQKLVVEENNSIEDYRPSNSNEFDLELANTINNLFEDLNNESDGRDEPSPKKPKKTKKLRSETYCTSCKTDLGSQDSFKQHNVDIHSLENGCFKCFGCNRPFKHRKRCLRHETDYCKALKKGYKCGICKKFLQKRSNFEKHLRAHKENKNLDLPEELFQCKKCVKQYTSMESLNEHMTMHEKDRNNWVCDTCGRVFSRRDYLYKHKLIHEGTKQHVCPHCGFRTIQKSSLNVHIRYNAPAVLHMNQPHLLLL

Sequence clustering based on sequence similarity using MMseqs2