Basic Information

Gene Symbol
-
Assembly
GCA_947578815.1
Location
OX388222.1:5322681-5331020[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 28 0.0041 0.33 12.4 6.1 1 23 38 60 38 60 0.97
2 28 0.00056 0.046 15.1 1.5 2 23 87 109 86 109 0.95
3 28 0.41 34 6.1 0.4 2 23 132 154 131 154 0.93
4 28 0.00065 0.053 14.9 0.3 2 23 160 182 159 182 0.94
5 28 0.089 7.2 8.2 3.5 1 23 189 212 189 212 0.95
6 28 4 3.2e+02 3.0 0.2 2 13 218 229 218 240 0.70
7 28 0.003 0.24 12.9 2.2 1 23 247 270 247 270 0.96
8 28 0.0017 0.14 13.6 1.1 2 23 277 298 276 298 0.95
9 28 0.0016 0.13 13.7 0.6 1 23 304 326 304 326 0.98
10 28 8e-05 0.0065 17.8 1.5 2 23 333 354 332 355 0.94
11 28 0.013 1 10.9 5.6 1 23 392 415 392 415 0.95
12 28 2 1.6e+02 4.0 0.7 2 23 442 463 441 463 0.94
13 28 4.8 3.9e+02 2.7 0.6 2 23 486 508 485 508 0.92
14 28 0.0037 0.3 12.6 0.1 1 23 514 536 514 536 0.95
15 28 0.00036 0.029 15.7 1.8 1 23 544 567 544 567 0.94
16 28 0.076 6.2 8.4 0.4 1 23 572 595 572 595 0.92
17 28 0.0043 0.35 12.4 1.0 1 23 602 625 602 625 0.96
18 28 0.0032 0.26 12.7 0.8 1 23 631 653 631 653 0.92
19 28 0.0066 0.53 11.8 4.1 1 23 659 681 659 681 0.98
20 28 3.1e-08 2.6e-06 28.5 1.9 1 23 687 709 687 710 0.96
21 28 0.00013 0.011 17.1 2.4 1 23 754 776 754 776 0.98
22 28 0.26 21 6.7 0.6 2 23 846 868 845 868 0.96
23 28 0.018 1.5 10.4 0.4 3 23 876 897 875 897 0.95
24 28 0.7 57 5.4 1.1 1 23 902 925 902 925 0.84
25 28 0.085 6.9 8.3 3.8 1 23 930 953 930 953 0.97
26 28 2e-05 0.0016 19.7 3.8 1 23 958 981 958 981 0.96
27 28 0.015 1.2 10.6 0.2 1 23 987 1009 987 1009 0.97
28 28 0.82 66 5.2 0.5 1 23 1017 1039 1017 1039 0.97

Sequence Information

Coding Sequence
ATGTACGTGATTGCGCAACCAAACGCCGCTGACACACATCGAATGAGGAAGTTACTGTGGCTGATCATATTAAACTCAACCGCCATGCCTTTCAGGAGGTGCGGCAACATATATAAATGTTTCTTCTGCTCTAAGACCTTCCACAAATCCAGTGATCTAAAGGTACACACGTCAAACCATGACGATGCCAATCAGAGATTCAGTGTCGTGAGTAGATTCGATGGGAGGGCTTCTATCAAAGTGGACATTACTGAACTGAGGTGTAGGCAATGCGATAAAGAATTCGACACTCTAAAAAATCTCCTCAGCCATCTAAAACAAACCCACAATGAAAACATCGACATGGAAGCGTTGAAGCACATTGACAGCTTCAAATTATCAGATAGCGCACTAAAATGTCTGCTGTGCGATGAAACCTTCGAATATTTCAATCCTCTACTGCTGCATACTTTGAGGTTTCATAAAATGAGGCCGCTCATATGCGAGCTTTGTGGTGTAAGCTTTTCTACCAAACGCAGCATGGCCAGACATTTCCAAAGCGCACACGAAACCAACAGAAGAACTTACAACTGCACCCACTGTAGTAAAAACTTCTCCGCTCCCCACAGACTAGACGACCACGAAAAGCGAATTCACAACATCAAAGCTCGAAAGTGCCATATCTGCGGAGAAGTCCTAGGCAGCACATCCATAAAGGCGAATCATTTGGCGACAGTCCACAACTTCAGGGTGGCGGAATTCAAATGCGAGAGCTGTCCCAAAATCTTCCGTCTCCAACACCAGTTAGCTATACATAACAAGAGAACGCACTTGAAAGAGAAAACTAAAGTGTGTGATGTGTGTGGCAAGAAATTCTTTGACAAAAAGCTCCTCAGCTTGCACAAGGTTAGACACAGTGGAACAAAGTGTTTTGAATGTGATATTTGTAAAAAGAAGTTTTTGAGGAAGAAAGGGCTGGATATACACGTGAGGATTCACACGGGAGACAAGAGATGTGTGTGTACGGTGTGCGGGAAGGCTTTTGTGCAGACGGCGAGTTTGAAACTTCATGGCAGAGTTCACCATGACCACAACATTGACCAAGAGGCCCGTAAGCGGGAGGAACTGGTCAAACTCCTCACCATTATCATAGAGAACTCCACGGTCTTACCCTTCAAATGGCACGCCAACGGCTTCATGTGCTTCTACTGCGGCTGCCCTTTCGCTGATTGTACTGAACTCAAACATCACACCAAGGCAGAACATGAGGACGCCAAACTCAAAACAGTATTGAGGACAACTGTTGCTAAAAGCAGAAGCATTAAGCTTGATGTTTCAGAGCTGTCTTGCAAGAAATGCAAGGAACCTATGCGGAGTTTACAAGAGTTCTTCCTCCATATAGAACAACACGGTTTTAAGGTCGATAAGGAAGCGACGCACTGCTGTTATCCATTCATCCTTAAAGATCACGACTTGTCCTGTCTTGAATGCGGAGTGCTCTTCAGATTCTTTGGACCTCTTCTCATCCACACGCACAAATATCACAGCAAAACTGAGCCGTTCCTCTGTGAGATCTGCGGACAAGGCTTCATAGCGAAAGCTAATGTAGAAAGTCATCGAAAAGTGCATCGAAAACCAGCCACTTCTAATTACAATTGTAAAGAATGTAACGAAACGTTCCCTACACAGTATAAACTAACGTATCATTTTGAGAAAGTCCACACACCAACGAAATTCAAGTGTCCTAAATGTCCTGAGATCTTGGGTAGTAAATACTTGAAGAAGCGGCATTTGGCTTTCGTACACGACATGAAAAGCGCACAGTTCAAATGCGATCAGTGTGAGAAGATATTCCCGTTGAAAAATAAGTTACTACAGCATAAGCTACGCGTCCATTTAAAGGAGAGGAACTTCGCCTGCGAAATTTGTGGTTTTAAAGTGTTTAGTAAAGATCTGTTGAAGCGGCATAAGGTGAAACATGACGATTCCCGACCGTTTGAGTGTGATTTCTGTAAGAAAACCTTTCAAAGGAAGAAGACTTTGGAGTTCCATAGAAGAATTCATACGAACGACAAGAGGTATCAGTGTAAAGAGTGCGGAAGATCGTTTGTGCAGTGGACCAGCCTCAAGCTTCATATGAGAGTGCATCATTCGAAACCAAAGAAGCACGACATCAGAGTACCGACGCAGCTGGACTGGCAGAAGGACGCCGCGCGCCGCTACTGCCACTCCGTCCTCTCCCACTCGTCCCTCCTCCCCTTCCGCTGGCGCGGCAACCGCTACATCTGCTTCTACTGCCACTTCACCTTCCCCGAGGCTTCTGCCCTGCGCACGCACACACGCACACACCAAAACCTGCAGATAATGAAGCATCTAACACAGACCAGGGAATTCACTCCTATAAAAGTAGATGTCGGAGAAACGCTGAAATGCTTGAAGTGTACACATGAGGAGACTAGTTTAGAAGGCTTGATTTTGCATTTAAAAAGCCATAAAGTTATAGGAGATATAGATCAGGAATGCTTCTTGCCTTTCAAGTTAGCGGATAACCAGGTGTCTTGCTTGAAATGCGCGAAGTCTTACCAATTTTTCGGTATGTTGTACTCGCATATGAATAAAGCTCATTTGGAAGGCACTGAGCGCATTTGCGAAGCTTGCGGGCAGAGCTTTTTCTCAGACTTCAGTCTCAGAAAGCATGTCCAATCGTACCATTCGACTGCCGATTTCAAATGCGGGCGCTGCAACCAAACTTTCAAGTTGGACGCTAACCGCATAAGCCACGAGTATAAAGAACATAATATAAAGACTTTCAAATGTTATAAATGCGAGGAAATGTTCGGTTCGCAGTATTTAAGGCGGTTACACATGCACAGCACGCATCTAAAGCTCGAATTCACATGCAAGGAGTGTTCCAAGACATTTCCTCACAAAACACAATTAACGAAACATGTGAGCCGGGTACATTTGAAAGAGAAGAGCTTCTCTTGTGTCATTTGTGGGGATAAATTCTTTGATCTCGCAGGCTTGAACGTGCATACTAAGAAGCATTCGAAAACTGTGGAGAGGAGTTTTCAATGTAAAGTTTGTATGGTATGTGTGGGTAGTAAGATGGAGTTGGATGAGCATATGGTGACTCACGCGGGACAATCGCTGTCACTAAAGTAA
Protein Sequence
MYVIAQPNAADTHRMRKLLWLIILNSTAMPFRRCGNIYKCFFCSKTFHKSSDLKVHTSNHDDANQRFSVVSRFDGRASIKVDITELRCRQCDKEFDTLKNLLSHLKQTHNENIDMEALKHIDSFKLSDSALKCLLCDETFEYFNPLLLHTLRFHKMRPLICELCGVSFSTKRSMARHFQSAHETNRRTYNCTHCSKNFSAPHRLDDHEKRIHNIKARKCHICGEVLGSTSIKANHLATVHNFRVAEFKCESCPKIFRLQHQLAIHNKRTHLKEKTKVCDVCGKKFFDKKLLSLHKVRHSGTKCFECDICKKKFLRKKGLDIHVRIHTGDKRCVCTVCGKAFVQTASLKLHGRVHHDHNIDQEARKREELVKLLTIIIENSTVLPFKWHANGFMCFYCGCPFADCTELKHHTKAEHEDAKLKTVLRTTVAKSRSIKLDVSELSCKKCKEPMRSLQEFFLHIEQHGFKVDKEATHCCYPFILKDHDLSCLECGVLFRFFGPLLIHTHKYHSKTEPFLCEICGQGFIAKANVESHRKVHRKPATSNYNCKECNETFPTQYKLTYHFEKVHTPTKFKCPKCPEILGSKYLKKRHLAFVHDMKSAQFKCDQCEKIFPLKNKLLQHKLRVHLKERNFACEICGFKVFSKDLLKRHKVKHDDSRPFECDFCKKTFQRKKTLEFHRRIHTNDKRYQCKECGRSFVQWTSLKLHMRVHHSKPKKHDIRVPTQLDWQKDAARRYCHSVLSHSSLLPFRWRGNRYICFYCHFTFPEASALRTHTRTHQNLQIMKHLTQTREFTPIKVDVGETLKCLKCTHEETSLEGLILHLKSHKVIGDIDQECFLPFKLADNQVSCLKCAKSYQFFGMLYSHMNKAHLEGTERICEACGQSFFSDFSLRKHVQSYHSTADFKCGRCNQTFKLDANRISHEYKEHNIKTFKCYKCEEMFGSQYLRRLHMHSTHLKLEFTCKECSKTFPHKTQLTKHVSRVHLKEKSFSCVICGDKFFDLAGLNVHTKKHSKTVERSFQCKVCMVCVGSKMELDEHMVTHAGQSLSLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-