Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0032 0.31 13.0 0.6 2 23 158 180 157 180 0.93

2 6 2.6e-05 0.0026 19.6 0.6 2 23 204 226 204 226 0.96

3 6 1.8e-05 0.0018 20.1 0.3 1 23 232 254 232 254 0.98

4 6 0.0032 0.31 13.0 0.4 2 22 263 283 262 287 0.92

5 6 2.3e-05 0.0022 19.8 0.4 1 23 295 318 295 318 0.91

6 6 0.041 4 9.5 0.4 1 13 324 336 324 337 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0032	0.31	13.0	0.6	2	23	158	180	157	180	0.93
2	6	2.6e-05	0.0026	19.6	0.6	2	23	204	226	204	226	0.96
3	6	1.8e-05	0.0018	20.1	0.3	1	23	232	254	232	254	0.98
4	6	0.0032	0.31	13.0	0.4	2	22	263	283	262	287	0.92
5	6	2.3e-05	0.0022	19.8	0.4	1	23	295	318	295	318	0.91
6	6	0.041	4	9.5	0.4	1	13	324	336	324	337	0.90

Coding Sequence: ATGGAAAGGAGTATGCTGGGTGTCCGAAAGAGTGACCGAATGAGAAACTCCGAGATAAGGCATAAGACCACAGTACAGGATGTCTCGACCAAAGGGACTCCGAAATACGCGCTCTACCAGCCGCCTCGGCTGTCGACCCATCTTGTAACGGCTGTGAGCTATCCCCCGTTGGACATTAAACCGGAGCCAATAGACAACGCAGTCAATGTGGAGTTCATAGACGATATAAAGGTTGAATTGGACGATACCGTAGAACACTGTGAACCGGAGGCATTTGTCAATGAATTGGAACTAAAGAAATGCGAGGATTTAGAGAAGAGTCAGGATTTGAAAAAGCCaagcaagaagaagaaaaagaagttAAAAGGAGgtaaaaagaagaagaaattaGACGAGCCTGTGTCAGATGGGATCAGCGACAGAGACTGTGATAATATTGACGATGAGGATAACGGTATTCCTGTCAAATGTATGTGTTCCGAGTGCGGGCTCACTTTTGATGACAGGCCATCCATGGATCGACATGTCAAGGAGGAACATTTGaagGATAAGGTTGTGAATGCACCGAAACCCAGGACCAGGAGTAAAGAGGTGTTAGCGGAGCGGCCCACATGCGCCGAGTGTGGAAAGGTCTTTAGTTCTAGGAAGACTTACAGATACCATCTCAATGTGCTGCACAAGGGACAGAATAGGTATCCGTGCCCGCGCTGTGGCAAGGTGTACCAGTGGAAATCCAACCTCGGCCGCCATCTTAGAACACACAAGGCGAGAGACGACGGAGAGTTGTACTGCGCCCTCTGCGACAAGCGTTTCGCTTCGGTGGCGACATACCGGCAACATCTGCGCGTGTCGCGGCGACACGTCTCCGAGAGCGAGTTCAGTTTCGTGTGCAACGAGTGCGGTAAGAAGTTTGTGAACAAAACAAGACTGCGCGACCACGTGGATTGGGAGCATTTGAAGAAAATCAAGTTCCGCTGCCAGCAGTGCAATAAGGTATTTgaacgtctgtctgtctgtgtaaaGGCGGGGTCCCACGGCCCGCGTTTTGCACAGGCCAGGCCACGCCTGTGA
Protein Sequence: MERSMLGVRKSDRMRNSEIRHKTTVQDVSTKGTPKYALYQPPRLSTHLVTAVSYPPLDIKPEPIDNAVNVEFIDDIKVELDDTVEHCEPEAFVNELELKKCEDLEKSQDLKKPSKKKKKKLKGGKKKKKLDEPVSDGISDRDCDNIDDEDNGIPVKCMCSECGLTFDDRPSMDRHVKEEHLKDKVVNAPKPRTRSKEVLAERPTCAECGKVFSSRKTYRYHLNVLHKGQNRYPCPRCGKVYQWKSNLGRHLRTHKARDDGELYCALCDKRFASVATYRQHLRVSRRHVSESEFSFVCNECGKKFVNKTRLRDHVDWEHLKKIKFRCQQCNKVFERLSVCVKAGSHGPRFAQARPRL

Sequence clustering based on sequence similarity using MMseqs2