Edem037280.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Epinotia demarniana
Gene Symbol
-
Assembly
GCA_945869435.1
Location
CAMBUM010000811.1:338078-358363[+]

Transcription Factor Domain

TF Family
P53
Domain
P53 domain
PFAM
PF00870
TF Group
Beta-Scaffold Factors
Description
P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [PMID: 20066118, PMID: 12629332, PMID: 1397838, PMID: 6544917, PMID: 19826090, PMID: 19776744, PMID: 6278740, PMID: 221923, PMID: 6318442, PMID: 20030809].This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [PMID: 11780147]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PMID: 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 25 1.3e-49 6.9e-45 154.8 0.0 3 191 81 272 79 274 0.90
2 25 0.36 1.9e+04 -3.2 0.2 181 191 318 328 317 329 0.92
3 25 0.16 8.2e+03 -2.1 0.2 181 191 374 384 372 385 0.91
4 25 0.36 1.9e+04 -3.2 0.2 181 191 430 440 429 441 0.92
5 25 0.36 1.9e+04 -3.2 0.2 181 191 486 496 485 497 0.92
6 25 0.36 1.9e+04 -3.2 0.2 181 191 542 552 541 553 0.92
7 25 0.16 8.2e+03 -2.1 0.2 181 191 598 608 596 609 0.91
8 25 0.36 1.9e+04 -3.2 0.2 181 191 654 664 653 665 0.92
9 25 0.36 1.9e+04 -3.2 0.2 181 191 710 720 709 721 0.92
10 25 0.36 1.9e+04 -3.2 0.2 181 191 766 776 765 777 0.92
11 25 0.36 1.9e+04 -3.2 0.2 181 191 822 832 821 833 0.92
12 25 0.36 1.9e+04 -3.2 0.2 181 191 878 888 877 889 0.92
13 25 0.36 1.9e+04 -3.2 0.2 181 191 934 944 933 945 0.92
14 25 0.36 1.9e+04 -3.2 0.2 181 191 1030 1040 1029 1041 0.92
15 25 0.36 1.9e+04 -3.2 0.2 181 191 1086 1096 1085 1097 0.92
16 25 0.36 1.9e+04 -3.2 0.2 181 191 1182 1192 1181 1193 0.92
17 25 0.36 1.9e+04 -3.2 0.2 181 191 1238 1248 1237 1249 0.92
18 25 0.36 1.9e+04 -3.2 0.2 181 191 1357 1367 1356 1368 0.92
19 25 0.36 1.9e+04 -3.2 0.2 181 191 1413 1423 1412 1424 0.92
20 25 0.36 1.9e+04 -3.2 0.2 181 191 1469 1479 1468 1480 0.92
21 25 0.36 1.9e+04 -3.2 0.2 181 191 1525 1535 1524 1536 0.92
22 25 0.36 1.9e+04 -3.2 0.2 181 191 1581 1591 1580 1592 0.92
23 25 0.36 1.9e+04 -3.2 0.2 181 191 1677 1687 1676 1688 0.92
24 25 0.36 1.9e+04 -3.2 0.2 181 191 1773 1783 1772 1784 0.92
25 25 0.36 1.9e+04 -3.2 0.2 181 191 1862 1872 1861 1873 0.92

Sequence Information

Coding Sequence
ATGCTGAAGCAGGAGAGCTCGAGTATCACCGAATTCGAATTCGGTGATCTGGGCGACACCGACATACTAAGCGGTGTCAACCTGGAAGACCTAGAGCGTCTCGGCAGCTTCAACAGCCAGGGCAACTTGCAGGTGCTCTCTCCAGACTCTGAGGTGACGCTCGACATCAGCTATGCCATTCACGACGTACCCAGTACTGAAAACATGATGCCGGTGTCCCCGCGCGGCCCGCCCGCCCGCACGTCCTTCGCAGGCGGCCTCAACTTCGCCGTGGAAATCAACGCTGCGGACACCAATAGAAAGAAGTATCTCTACTCGGACAAGCTGAACCGTATCTACGTGGACATAAAGACGAATTTCGCGGTTCAATTCCGATGGGACTTCGACGTCGCTGCGACTCCGATGTTCGTGCGCGCCACCACCGTGTTCTCGGACGAGGCGCAGTCCGAGAAGAGGGTCGAGAGATGTCTGCAGCACACACATGAAAGTGCTAATGCTGCCATAGATCCGGTGATAGTGAAGAACGTCCTCCACTCGTCCGCCGCCCCGGGCACCCAGGGCGTGTTCTACTGCGGAGCGCCCTCTGTCCCGGACTCGTGGTACTCCGTGCTGCTGCGCTTCGACGGGCGCCCGCAGGAGCCCTACTCGCACGCCTACCAGTTCGTGTGCAAGAACTCCTGCTCCAGCGGGATCAACAGGCGCTCTATAGAAATCATCTTCACTCTGGAGGATCATACAGGCCAAGTGTACGGCCGGCAGACCGTGGGTGCCCGTGTGTGTGCctgcccgcgccgcgacaaGCTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCCctgcccgcgccgcgacaaGCTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCCctgcccgcgccgcgacaaGCTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCCCTGCTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGGTCAGTACACTGGTCACATTCCCTGCTCcctgcccgcgccgcgaccagcTCAAGGACGAGGAGGTGGAGCCGCGGCCCAACAAGCGgcgcgcgtcgccgcccgcgcagccgcaGCCCGGGAAGAGGGTCAAGGTGGAGCCCGATGACGACGTGCTCGTGCTGCCCGAGCTTCCGATAGTGGGCAGGCGTACCATGATCACCGGCCTTGAAGTCATGCTCAACATGATGGAGGCAGTGGCGACCAAGACGCCCGATCACGACCAGGACAAATACCAGACCTCCATCCGAGCGCTCCGGGACAAGATAGAGGAACTGAGGGGTCCGCAGGCTGAGTAA
Protein Sequence
MLKQESSSITEFEFGDLGDTDILSGVNLEDLERLGSFNSQGNLQVLSPDSEVTLDISYAIHDVPSTENMMPVSPRGPPARTSFAGGLNFAVEINAADTNRKKYLYSDKLNRIYVDIKTNFAVQFRWDFDVAATPMFVRATTVFSDEAQSEKRVERCLQHTHESANAAIDPVIVKNVLHSSAAPGTQGVFYCGAPSVPDSWYSVLLRFDGRPQEPYSHAYQFVCKNSCSSGINRRSIEIIFTLEDHTGQVYGRQTVGARVCACPRRDKLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDKLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDKLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPELKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPELKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCSLLPARAATSSRTRRWSRGPTSGARRRPRSRSPGRGSRWSPMTTCSCCPRSVHWSHSLLPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPELKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPELKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPEVSTLVTFPAPCPRRDQLKDEEVEPRPNKRRASPPAQPQPGKRVKVEPDDDVLVLPELPIVGRRTMITGLEVMLNMMEAVATKTPDHDQDKYQTSIRALRDKIEELRGPQAE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-