Basic Information

Gene Symbol
-
Assembly
GCA_932527255.1
Location
CAKOBP010000025.1:550194-556330[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.014 0.88 10.3 0.1 3 23 30 50 28 50 0.96
2 17 0.00064 0.042 14.4 2.0 1 23 56 79 56 79 0.96
3 17 0.36 23 5.8 0.5 3 23 84 106 83 107 0.85
4 17 0.0058 0.38 11.4 0.1 1 22 114 135 114 135 0.95
5 17 2.8e-06 0.00018 21.8 0.9 1 23 143 165 143 165 0.98
6 17 0.00011 0.0071 16.8 3.5 1 23 171 193 171 193 0.98
7 17 6.9e-05 0.0045 17.5 1.3 1 23 199 221 199 221 0.95
8 17 0.016 1 10.0 1.4 2 21 228 247 227 248 0.95
9 17 0.31 20 6.0 0.2 2 23 688 710 687 710 0.95
10 17 0.26 17 6.2 0.7 1 10 734 743 734 756 0.75
11 17 4.1 2.7e+02 2.5 3.1 1 21 764 785 764 788 0.88
12 17 2 1.3e+02 3.4 0.8 3 23 794 815 794 815 0.96
13 17 0.0063 0.41 11.3 0.3 2 21 828 847 827 848 0.93
14 17 0.00019 0.012 16.1 0.9 1 23 856 878 856 878 0.98
15 17 5.9e-06 0.00038 20.8 1.8 1 23 884 907 884 907 0.97
16 17 6.1e-05 0.004 17.6 1.3 1 23 913 935 913 935 0.98
17 17 0.00039 0.026 15.1 1.1 1 21 941 961 941 962 0.95

Sequence Information

Coding Sequence
ATGGCCGATGCCAACGATGCTTCCACATCGTCCGCTGCAGCAGCCATGCTCGTTAAACTCTCCACCGATGGCGTTCCCAAACTGTTCTGTCCGGTTTGCAACAAGGCCTTGGTGTCGCTTGCCGGTTATGTAAAGCATGTTAAGAAACACGAACCGCCCGGTGGTTTTGTATGTCGTTATTGTGAGGCGCGTTTCTGTTCCGAAGATGAGTTGAAAAAACATCGGGAATCTGAACATACCACCATCGCCTGCCGTCTATGCAAAGATGTTACCTTCACGAATGAAGATGACTATCGGGTACACATTCGCGATATACACCATGGAGTGGATCGAGAGATATTTACTTGCGAAAAATGCGGAGCCGCTTATAAAACTATAGATCCTTACCGACGTCACATCGAAACGGAGTGTGGTCGTATTAAGCCCTATAAATGTGATAAATGTCCCATGGCATTCGTTACGAAATATAACCTAAAGCAACATTTAGAAAATCATTCAGGCGAACTGAAGTTTTGCTGCAGCTACTGTGGGCGTAACTTTAAACAAAAGGCTCGTTTGGTGGAGCATGAAAGGACTCATACGGGGGAGAAGCCCTATAAATGTGATGTTTGTGGCAAAAGCTTTTCTCATCGTGAAAGCATCGTAACGCATTCTTCTATTCATACTGGTATACGGTTGGTAGAATGCAAAGGATGTGGTTCCAGATTCTCCTGTTATTCCAATCTAATTAAGCATCGGCGCAATCGACCAGATACTTGTGGCTTACCGGAATTTGATCCACCCAGAAATCGTGTTCGAAAATTTACATCCAGAATACCGGCCACGTTGAATCCCACCTCCGAAATCAAGGTGGTTAACGTTAATAAAATAATTAAACTCGACGATCAGGTGAAGGCGGCAAATTCGAAAAAGGAATCGCCCGAAAAAAATTACAGAACAAAACCTACAGCTCGTAAGCGAACAGGAGGTGCTAAACCAGCACCAATTGCTCTACGCAAAAGAGCTCCCAGAAGAAAGGTCATGGGCTTTGATGTTCTAGAAGTCTGTGAGGATTCAAAAACTGAAGCATCCGTTATTAAAGACATTCTTAAGGAGGACGATAGCTCACTTGAACCGAAGCAAAAAATGGAAGTAGAAGGGGAAGAATTTGAGGATGATAATAGTATGCCGCCACCTGTGCCGGAAATCGTTATTAATGATATGCCCTTGCAAGATAAAACTGGTACTCCATGGTCTGATGATAGTGAAGATGAATATGTGCCAGATTTTGAGGCTGATGATTCAGATTCCGATGAAGAAAACGGCAAATCACTTAAAGACTTTAAAGTTCAATTGCCCACAACCTCCATTAAGCAGGAGAACTATGAAGAAGACGACAGAGATGTGGCCGTTGCTACAAACATACAAATAGAATCACTGGCCGATTTCGAGTATACACCCATGGAAGATTCCTATAGCGCTGAGGTAAAATACGAAGATGAAGATAATTTATTTGATGAAAAGGATCGGATATTAGAGCATCTACTAAACGAAAATGATTATAGTACCGTCTCTGAAAAGAGCCAACTTAATTCTGGTTATCAGTCCAGACCGAAAAGGAAGCGTAGAATGCCCCAGAAAAAATATAGTCAAGATTCTGATGATATATTGAGAGAGTCTGAAATGGCGTATATAAAATTTGAAGAAAGTGATGATGTCGATGATGACAGTGAAGACATTCTGGAAAAAAAATTTAAGGCCAGTGAACTTGACGAAGATGACCTCAAAAACTGCTATGTCTTACTGGAGGACGTGACCAGCTGTTTTCCTACGTTGAAGGAAACCTCTTCAGTGAAAGTGCCACGAAACGCTGCACCCTTCTTTTCAAAGTCTGAGAAAATCAAGAAATTTATTAAGAAGCGTGGGAAATATCGGCCCAGGCGATCGAAGAAAATTAAAAACGAGCCCGATTCCGAAGCCGAAGAAGATTCAAAATCTGGAAAATCTTATCGTTTAGCTTCAATATCGGCCAAACAATTAAAGGAACGCATGAAACTTATACGAAAACGCGATAGGTCTTGGAAGTGTCCAGACTGTATAAAAATTTATTACATGCGCAAACCTTATGAAAAACATTTACGTGAAGATCATAAAAGATCCGAAGAGTTTATTAAAGATGTCTTTAAAAATGATTTTGAGGAAGTTTCGAACGATGATGTTTTTAAATGCCATATATGCGATAAAATTTATTTAATGGAGAAACGGCTAATATCTCATATACCCAAACATGGCCCGGATGGTAGTTTGATACACAAATGTCCCTGTTATTGTACTTTATATTTTGCTTCGCGTGAGGAGGCCATCGCTCATGCTCATGACAAACACAAAGATCTCCTGTGGTGTGAAATATGTGAGAAATACATGACCGGCTGTGATGCTCTTAAATCGCATAGAGCACGTATTCATGGCGGTAATAAAGACTATAAAAATTCCCGTAACTTAGTGTGTATGAAGTGTGGCAAGAAATTTATGGGGCGTACTCAATTAACCGATCACGAGCGTTCGGATTGTGGTCGTGTGCCTTTATACCAGTGTCAAGAATGTGGCAAATGTTTGACCACGGCCGGTATACTTAAAACACATATGTTATTGCATAGTGATGCACGACCGTACCAGTGCGATAAGTGTGGCAAAACATTTAAAATCAAGGCTCAATACAAGACTCATATTAAATACGCCCACACGGACGAAAAACGCTTTAAATGCCATCTTTGTCCAAAAGAGTACCCTTATCGCGAAAGTCTACTTACGCATATGTCCGTCCATACTGGTATTAAACGTTTTATGTGTAATGGCTGTGGCAAACGTTTCACCTGTGTCTCCAATCTTCAAGCACATCGTAAAGTTCAGGCTGAAACTTGCGGCCTGTTGCCATTAAATGCCAAAGCTACCCAGTACATGGGTGTGCAAAAAGGCAATCTTCTAATGGGAGCAAAGCCAGAACCGGGATTAGACTATGTAGAAACTAGAACGTTTGTAGCAAAAGAAGTTATTACGCATGATTTGCCGATGGCTCAAGAATTACACAGTCAAAGCAGAGGTTTGCCACATGATGGGTCTCTGAGCGACGGTATTCCTTTAAACTACGTTACTTCAGGATCTGAGTTTATACTGATGTATAACAGAGATTAG
Protein Sequence
MADANDASTSSAAAAMLVKLSTDGVPKLFCPVCNKALVSLAGYVKHVKKHEPPGGFVCRYCEARFCSEDELKKHRESEHTTIACRLCKDVTFTNEDDYRVHIRDIHHGVDREIFTCEKCGAAYKTIDPYRRHIETECGRIKPYKCDKCPMAFVTKYNLKQHLENHSGELKFCCSYCGRNFKQKARLVEHERTHTGEKPYKCDVCGKSFSHRESIVTHSSIHTGIRLVECKGCGSRFSCYSNLIKHRRNRPDTCGLPEFDPPRNRVRKFTSRIPATLNPTSEIKVVNVNKIIKLDDQVKAANSKKESPEKNYRTKPTARKRTGGAKPAPIALRKRAPRRKVMGFDVLEVCEDSKTEASVIKDILKEDDSSLEPKQKMEVEGEEFEDDNSMPPPVPEIVINDMPLQDKTGTPWSDDSEDEYVPDFEADDSDSDEENGKSLKDFKVQLPTTSIKQENYEEDDRDVAVATNIQIESLADFEYTPMEDSYSAEVKYEDEDNLFDEKDRILEHLLNENDYSTVSEKSQLNSGYQSRPKRKRRMPQKKYSQDSDDILRESEMAYIKFEESDDVDDDSEDILEKKFKASELDEDDLKNCYVLLEDVTSCFPTLKETSSVKVPRNAAPFFSKSEKIKKFIKKRGKYRPRRSKKIKNEPDSEAEEDSKSGKSYRLASISAKQLKERMKLIRKRDRSWKCPDCIKIYYMRKPYEKHLREDHKRSEEFIKDVFKNDFEEVSNDDVFKCHICDKIYLMEKRLISHIPKHGPDGSLIHKCPCYCTLYFASREEAIAHAHDKHKDLLWCEICEKYMTGCDALKSHRARIHGGNKDYKNSRNLVCMKCGKKFMGRTQLTDHERSDCGRVPLYQCQECGKCLTTAGILKTHMLLHSDARPYQCDKCGKTFKIKAQYKTHIKYAHTDEKRFKCHLCPKEYPYRESLLTHMSVHTGIKRFMCNGCGKRFTCVSNLQAHRKVQAETCGLLPLNAKATQYMGVQKGNLLMGAKPEPGLDYVETRTFVAKEVITHDLPMAQELHSQSRGLPHDGSLSDGIPLNYVTSGSEFILMYNRD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01376814;
90% Identity
-
80% Identity
-