Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.31 39 6.5 2.1 2 21 49 68 48 71 0.87

2 6 0.00021 0.026 16.5 7.5 1 23 77 100 77 100 0.96

3 6 0.00029 0.036 16.0 3.8 3 23 110 131 108 131 0.96

4 6 0.00085 0.1 14.6 1.8 1 23 138 160 138 160 0.95

5 6 1.8e-05 0.0022 19.9 4.4 3 23 168 189 166 189 0.96

6 6 7.4e-06 0.00091 21.1 0.5 2 23 195 217 194 217 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.31	39	6.5	2.1	2	21	49	68	48	71	0.87
2	6	0.00021	0.026	16.5	7.5	1	23	77	100	77	100	0.96
3	6	0.00029	0.036	16.0	3.8	3	23	110	131	108	131	0.96
4	6	0.00085	0.1	14.6	1.8	1	23	138	160	138	160	0.95
5	6	1.8e-05	0.0022	19.9	4.4	3	23	168	189	166	189	0.96
6	6	7.4e-06	0.00091	21.1	0.5	2	23	195	217	194	217	0.95

Coding Sequence: ATGGAAAACCCTAAAACTTTCGTGACAGCTTCTGATTCTGTGTTTGAAACTGAAGGCGCCAAATTTGCGGTCAATTCATTTGCCATCGCCACTTTGGAGATGGATAACAATGAAACAAATCACAATTCCGATCCGTACTACAGCTATTGCAGCCATTGTAATCTTAACTTTGAGAATGTGATCGAATTTGAACATCATAACACCGAAATGCACAGTCAAAGTAAGTTACACAAATGCAATTGTTGCGATGCTACGTTTAGACGTCAAGACCATTTAAAAAGACACATTCAAAGTTTACATTCAAATTCGGACGAGAAGTATTGCTTGTGCCCTGTCTGCGAGAAGGATTGCTCGCGACGAGATCTATTACTCAAGCATATAAGGAACAAACACACTAGTAAAAGTGAAGTTTTCAAGTGCAGAGTTTGTGATTTTAAGTGTACAACATTGTCTGGTCTTGAAAAGCATGAAATCGGACATTCCAAGACTGAGCGGCAGATATGCCCGCACTGTGACACCACATTTAAAAGACGAGACCATATGTTGAGGCATGTTAAGTCACAACATCTGAATGAGATAGTATCGTGTCCAGTTTGTGGGCAAGTGTACAAGAGGAAAGATCATGTGGCAAGGCATGTGAGAGAAAAGCATCAGATGGGGTTTCTGAACGGACGTTTGGTTAGGTCTGTGGATCTCATACAATCATAG
Protein Sequence: MENPKTFVTASDSVFETEGAKFAVNSFAIATLEMDNNETNHNSDPYYSYCSHCNLNFENVIEFEHHNTEMHSQSKLHKCNCCDATFRRQDHLKRHIQSLHSNSDEKYCLCPVCEKDCSRRDLLLKHIRNKHTSKSEVFKCRVCDFKCTTLSGLEKHEIGHSKTERQICPHCDTTFKRRDHMLRHVKSQHLNEIVSCPVCGQVYKRKDHVARHVREKHQMGFLNGRLVRSVDLIQS*

Sequence clustering based on sequence similarity using MMseqs2