Basic Information

Gene Symbol
-
Assembly
GCA_018467065.1
Location
CM031594.1:11229441-11234316[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.33 41 6.4 0.5 2 23 211 232 210 232 0.96
2 10 0.00029 0.036 16.1 4.7 1 23 238 261 238 261 0.97
3 10 0.00016 0.02 16.9 3.4 1 23 549 571 549 571 0.98
4 10 0.00018 0.022 16.7 2.0 2 23 577 599 576 599 0.97
5 10 6.1e-06 0.00075 21.3 1.8 2 23 608 629 607 629 0.97
6 10 0.00047 0.058 15.4 3.0 2 23 633 654 632 654 0.97
7 10 0.2 25 7.1 3.8 1 23 696 718 696 718 0.96
8 10 0.0029 0.35 12.9 1.6 2 23 725 746 725 746 0.98
9 10 0.00024 0.029 16.3 1.9 1 23 752 775 752 775 0.97
10 10 0.017 2.1 10.5 3.5 1 23 779 802 779 802 0.96

Sequence Information

Coding Sequence
ATGGAGGAAGATAATTTATCCGAATTTCTGGTTACAAAACAACATATAAAAGAATTACACGAAGAATTGAATATTAAAGAAGATACTGATAGCAACATCAAAGGTGTTTCAAACTTGAAGAGAGAACCGCTGACTACGAAAAATGCTATGAAATTACTATTAGAAGGAACTCTCAAATCGAAAGTTTGTCGATATTGCTTGAATGTGGACTATTCTCTTTATGAAATGGACCAAGTGTTCCAAATTGGGAGTCAAAATTCTCTGTATAAAGTAACTATACGAGACATGGTGGCAGGTTTTTATCCATTTCAGGTGGTAGAAGATCCGAATTGCCCTACAAAAATTTGTGAAAAATGTTTAGATAACGCTTTTCACTCATATCTGTTTACTCAGCAATGTGAGCAGGCTGGGCGAGCTTTACGCAACTGTTTTGAAGATATGTATGAAAAACTGGACAAACTAGATCCATTGGAACGAACAAAGAAGAGAggcagacaaaaattaaatccTAATTATAACACATTATATACAGAACATGAAAAAGTAATAGATTACGCTGATCCTATTATAAACATTGTTAATAAAGGATCTGAGCTAACTGAAAAAAAAGATGGTACAATTAATGACTTGGAATGTCCAAGGTGTTGGCAGACGCACACAAGCCTAGAATCCCTGATAAATCATGAGAAAATCCATCCTAAGTCTATGTGGTTTAATTGCCGTTTATGTGGCAAATCATTTGCGAAAAGACATCTTTATAGAAAACATGTGAAAACGACTCACAATAACTCCAAACAGGTAGCTTTGCCAGATCCCAGCTTTAAATGTTCAGAATGTGATGTTGGCAACGAAACATATGACAAACATTTGCAACATAttgaaaaacataaatttcAAATGGTTATGGAACATTTGGTTGAAAGGAAAATGGACAAACTATGTACTGTATGCTTAACAAAAGATGGCAATATGGTAAAATTAGATAGAACTGTAAATTTGCATGGTGGATGCCCAGAATTAACTGGACACAGGAGTTTGTACAATATTCTTGGTTCTACAATGCCTGAGATGAACATCCTTAGTTCATATACAGGGacaaaaatttgtaaaaaatgcctagaTAGTGCACTGACATCATATATATTCCTAAATCAAGCTCATTATGTAAGAAATAGACTGAAGACATGTGTTGAATTGATGCTCGATTGTTTGATGAATGTAGCCCAACCAGATGGGAAGATATTTGTTGAAATATCACAAGATGTGATACTACCAGCCAAGGAACCAGACTTTATAGATGAAAACTTGCTTATCGAAGCAGAAGAAATAGATGAAAGTAAACTTAGTGTGGACATTTTAGAGGACGAATTTAGAGTCAAAGAGTCTGAGAGTGAAAGTGATGTAGAAACTTCAATGAATAATACTGAAGTAAAGAATGAAAAAGACTTTATAAACGATATTGATATAAAAACGGAAGATTTGACTTTCAATCTAGCTAGAAATGCTACAAAAACATATGTTAAAGAAATGGTTAATGGATTACAATCAAAATTCAGAACTAGTTACAATTCTATCAGTAATGCCTGTAGTGAATTCTTAACattcaaaaagaaaaagaaacccAAAGGAATATATTCATGTAAATTTACATGCCCTTTGTGCAATAAACATTTCATTTCTGATTATTTCCTAAGAAGACACATTAGCAGACATGTTTTGAAGAACGTACAGTGCAAAATATGTAACACACAGTTCAAATCAAAGTTCAACTTGTATGAGCACACGAAAATGATGCATTTATTAGGAAATCCAAACTTCAGCTCATGCAAAACTTGTGGAAGGAATTTTGTAAATAGTAAAAAGTTGGTGAAACATATAAGAACTCATAAGACCAAAGAATGTCTATTATGTAGCAAAATTTTCGCAACACAACATCAGTTTAACAGTCATATGCAAAGGCATAGAATGAAATTAAAGTTTATTAGAGAAAAAGGAGTGCAAACGTGTAGTTTCTGTGAAACGGCTTGTTTAAACGATAACGAACTAACAGTCCATGTGAATAAGGTTCACTTGCAAATAAAACCTTTTAATTGTGATATGTGTGAAAGGCAATTTTATTCTGAAAACAATTTGAATTGTCATAAGAAAGTACACAGCATGAGTTCGAATGAGAAATGCAATTTTTGTAGTAAAACTCTGAAAAATAGAAAGGCATTGGTTATTCACGTAAGAAACCATATAGGTGTTAAGCCCTTTAAATGTTTAATATGTACACAGAGTTTCTATTCGCAAGGAAAACTGAAATACCATCTGAAAATATCTCACGGCGGTAAGTTTTGCTGCAAATTGTGTAAAAGTGTGTTTGTAACTAAATATAGACTCAAAGATCATGTGAATAGGGCTCATAACATTATTTAG
Protein Sequence
MEEDNLSEFLVTKQHIKELHEELNIKEDTDSNIKGVSNLKREPLTTKNAMKLLLEGTLKSKVCRYCLNVDYSLYEMDQVFQIGSQNSLYKVTIRDMVAGFYPFQVVEDPNCPTKICEKCLDNAFHSYLFTQQCEQAGRALRNCFEDMYEKLDKLDPLERTKKRGRQKLNPNYNTLYTEHEKVIDYADPIINIVNKGSELTEKKDGTINDLECPRCWQTHTSLESLINHEKIHPKSMWFNCRLCGKSFAKRHLYRKHVKTTHNNSKQVALPDPSFKCSECDVGNETYDKHLQHIEKHKFQMVMEHLVERKMDKLCTVCLTKDGNMVKLDRTVNLHGGCPELTGHRSLYNILGSTMPEMNILSSYTGTKICKKCLDSALTSYIFLNQAHYVRNRLKTCVELMLDCLMNVAQPDGKIFVEISQDVILPAKEPDFIDENLLIEAEEIDESKLSVDILEDEFRVKESESESDVETSMNNTEVKNEKDFINDIDIKTEDLTFNLARNATKTYVKEMVNGLQSKFRTSYNSISNACSEFLTFKKKKKPKGIYSCKFTCPLCNKHFISDYFLRRHISRHVLKNVQCKICNTQFKSKFNLYEHTKMMHLLGNPNFSSCKTCGRNFVNSKKLVKHIRTHKTKECLLCSKIFATQHQFNSHMQRHRMKLKFIREKGVQTCSFCETACLNDNELTVHVNKVHLQIKPFNCDMCERQFYSENNLNCHKKVHSMSSNEKCNFCSKTLKNRKALVIHVRNHIGVKPFKCLICTQSFYSQGKLKYHLKISHGGKFCCKLCKSVFVTKYRLKDHVNRAHNII*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-