Basic Information

Gene Symbol
Kr-h1
Assembly
GCA_018467065.1
Location
CM031567.1:6506410-6507486[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 8.9e-06 0.0011 20.8 0.3 1 23 18 40 18 40 0.98
2 8 2.1e-05 0.0025 19.7 2.7 1 23 47 69 47 69 0.98
3 8 2.8e-07 3.5e-05 25.5 2.3 1 23 75 97 75 97 0.98
4 8 2.9e-05 0.0036 19.2 1.7 1 23 103 125 103 125 0.99
5 8 1.9e-07 2.3e-05 26.1 1.6 1 23 131 153 131 153 0.97
6 8 8.3e-05 0.01 17.8 1.1 1 23 159 183 159 183 0.99
7 8 0.12 15 7.8 2.3 1 23 189 211 189 211 0.96
8 8 7.5e-05 0.0092 17.9 0.7 1 23 217 240 217 240 0.97

Sequence Information

Coding Sequence
ATGATTTCTACATTTAAATCGTATCGTTCGACAGGTGACGAAGAACGTGTTCATCAGTGCGGTGAGTGCGGATTGTCACTCTCTACGCGGAGTGCTCTGACGGCTCACGCGCGTTCCCACCGTGTTGCTGCTGATGCTCATCGCTGTGATGTTTGTCACAAAACATTTGCCGTTCCTGCCAGATTAGTTCGCCATTACCGAACTCATACTGGTGAACGACCTTTCGAGTGTGAGTACTGCCACAAGATGTTCAGTGTCAAGGAGAATCTTCAAGTACATCGTCGTATCCATACGAAAGAAAGGCCGTATCGCTGCAACGTTTGCGACGCAGCCTTTGAGCATTCAGGGAAGCTTCATCGTCATGCTCGGATCCATACTGGGGAACGTCCACATGCTTGCCCACATTGTGACAAGACATTTATACAGTCTGGTCAGTTAGTTATTCATCtgcgaactcacactggagaaaAACCTTACCGGTGCCCTGCTCCTGGATGTGGCAAAGGATTTACTTGCTCAAAGCAATTAAAAGTGCACTCGCGTACCCACACAGGTGAACGGCCTTATACTTGTGATATTTGCCTTCGAGATTTTGGATATAATCATGTTTTAAAATTGCATCGTTTTCAACATTACGGTGAGCGCTGCTATCGTTGTACAGTATGCGATGGAACATTTaacacgaaaaaacaaatggAGGCACATATTTATAAAGAACATGGTGCTGAAACTCCTCGCACTCAAACCTTACAGTCTTCAGTGCCAATTGTAGTAAATGGTAACGTCATGTGCGATTTAGTAGAAGCAGCTCTTCAACAATTGCCTCCAACGCCACCTAGTTCTCCTCCATCTCCGCAATGTCAAAGTGCACCGGTCGTGTCTGTTCCTGCTCCGTCATCTTTATCTCCAGTACATTTACCAAGTCAAGCGACGGCGTCTATACAGTATACAACAGTACATTCTTCATTACCACCGCGAAAGCGCAAGTTTATTCCTCAGCCAGAACCGGCACCTGTGCCAGTAGTGCGACACACTTCTGTAATACAATTTGCACCTGCAGTGGTCGATGCATCCTAG
Protein Sequence
MISTFKSYRSTGDEERVHQCGECGLSLSTRSALTAHARSHRVAADAHRCDVCHKTFAVPARLVRHYRTHTGERPFECEYCHKMFSVKENLQVHRRIHTKERPYRCNVCDAAFEHSGKLHRHARIHTGERPHACPHCDKTFIQSGQLVIHLRTHTGEKPYRCPAPGCGKGFTCSKQLKVHSRTHTGERPYTCDICLRDFGYNHVLKLHRFQHYGERCYRCTVCDGTFNTKKQMEAHIYKEHGAETPRTQTLQSSVPIVVNGNVMCDLVEAALQQLPPTPPSSPPSPQCQSAPVVSVPAPSSLSPVHLPSQATASIQYTTVHSSLPPRKRKFIPQPEPAPVPVVRHTSVIQFAPAVVDAS*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2