Basic Information

Gene Symbol
br
Assembly
GCA_000507165.2
Location
KZ497570.1:282387-292135[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.002 0.13 12.8 5.6 1 23 308 330 308 330 0.98
2 13 0.007 0.47 11.0 5.1 2 23 335 357 334 357 0.95
3 13 2.6 1.7e+02 2.9 7.0 1 23 390 412 390 412 0.93
4 13 0.00012 0.0081 16.6 7.9 2 23 417 439 416 439 0.97
5 13 0.008 0.54 10.8 5.3 1 23 485 507 485 507 0.97
6 13 0.0004 0.027 14.9 1.9 2 23 547 568 546 568 0.97
7 13 4.6e-06 0.00031 21.0 1.2 2 23 573 595 572 595 0.95
8 13 0.032 2.2 8.9 6.2 1 23 663 685 663 685 0.98
9 13 0.048 3.2 8.4 0.2 2 23 690 712 689 712 0.94
10 13 0.033 2.2 8.9 0.0 2 23 739 761 739 761 0.96
11 13 0.0012 0.082 13.4 2.7 2 23 771 793 771 793 0.96
12 13 0.0031 0.21 12.1 1.2 1 23 813 836 813 836 0.96
13 13 0.28 19 6.0 2.4 1 23 844 867 844 867 0.93

Sequence Information

Coding Sequence
ATGGGGAGCCAACAGTACTCTCTGCGATGGAACAACTACCTACGCCACATTACCTGCGCATTCGATTCCTTACGCAGTGATAAAGACTTGGTGGATGTGACCCTAAGTTGTGACGGGCAGAAGGTCCAAGCCCACAAGATGCTCCTATCAGCCTGCAGTTCCTATTTTAGAGATTTATTCAAGGAAAATCCTTGCCAGCACCCTGTAGTCATCTTCCGCAATGTGCGTTTTGAAGACCTTCTAGCGTTGATTGACTTCATGTATCAGGGGGAGGTGAATGTGGAGCAAGAGCAGTTGGCATCCTTCCTAAACACAGCTGAGCTACTACAAGTACAGGGACTCACAAATTCCAATTCGGAAAACAACACAATGACTGATGACTCACATACTAACACAGAGCCCAAGCTGGACGTTCCACCACCTGAAGTTCAATTTGAGGGTGACGACAGGTCTCCCAGATTCTTGCGAGAAGACTCCCCAATTTCTACTAAACCCTCGACCTCTTCTGCGCCGGCAGCCAAGCGACGGCgCACAGACGGAGGCTCAGACATTGGCAAGAGGAGTTGCAGTCCACCTGTAGAGATAACGCCGATGAAGATGGAGGCTCCGGACTATGTGGAGGAGGAGGACCAGGGAGACAGGGAAGATACAACGGAGGACACACTGGCAAGACTGAGAGAGAACGATGAACTGTTGCTAACCAAGAGCTCCTCCAATCAAAGGCTTGACCCTCATAGCTTCGGTACCAGTAGCATCACTCATCCCATGGATATTCTGCATACCACAGATACAGAAGCATTGGCTACAGCTGGCCCCTCCAGTGATGGTCACTCTCAAGATGGTTTACAAGGTAGCCTGATTCCAGGCCCCTCCCCCTCTCAAGCTGCAAACTTTATTGAGCGTTCCCGAAGTCACACTGGCTACTCATGCCGACTCTGTGGCAGGACATTTAACCACCGCGACTCTTGTCAAAAGCACATGGCCATGCACTTAGGCACATCCAAGTGTTACGTTTGCTCGTATGTGCTTAGTCGCAAGAGCCACATGAAACGCCATTTAAAACACGTTCACGGAATAGATCAGGATAgcTTTGCAACCCACTATCCTGATAGTTCTCCTTCTGATGCCTCAAGTGTGCTTACAATATTGAGGAACAACAGCAGACTCTTTGTCTGCAGCTTCTGTAACCGAGAATTCAAGCACAGAGTATCATGCCACCAGCATTTGGCATTGCATAAAGGAACTTCCAAGTGTCACATTTGCAACTGTGTGCTGAGTCGCAAGAGCCACTTAAAAAGACATCTCAAGACCATCCATGGCATTTGTAGTAGTCGACAGTATAGGTTGGCACCCCCTTCCTCTCACAAGCTACCACCTGCTCAACTGATACCCATTCGGCAACAAAAGACACCCTCTTTGAAAAACTTAATAGTGAGCGGTGCTGATGACAGTTTCATGTGCATGGTATGTGGTCGAGCATTCAAAGACCGCAAGTCATGCCACAGACACATGTCCATGCATCTCGGAACTTCGACTTGTCCCATTTGCTTCAGCATCCTCACCACTTGGATCAATGGGAGTGGAGGAGGACAGCAAcctgcagcagtagcagcagcaacagcccAGACATATGAGAAGGTTTGCAGTCAATGTGGCAAGGAGTTCAAACATTACATGTCTCTCGTGATGCACCGGCAAGTGCACATAGGACTCACCACCTGTTCCATTTGTGGTAAAGTCTTCAACCGAATGTACGATATGAAGAAACATATGAAAGCTAAACATTCTCACCAACATACAGACTGGCAAGCTGTCACTGCCATGGCAACAGCAGTGGAGAACTTAAAGCATTATTTCCTCCTTACAGATGGCTGGTTGCCGGCTCTCCCTCAGGCTCAGGACTCTGAAGTTTTGCCTCCAGAATGGTGTGGCATAACTCCCTCTACGGCCCCTGAATTTGTGATAGAACATGACAGCAAGAAAACTTTCCGATGTTCTTTGTGTAACATGGAGTACAAATCCCAGTCTTCTCTCAACTGCCACATGCATAGTCACACCAACAAAAGCAGGTGTCCTGTGTGTGGATCACTGCTCAACAGAATCTATGACTTGCGCAGGCACCTCATTAACACTCACAAATTGGAGCCAAGACCTGTGTTGAGTGGCAGCAAACTGCACCTTCCTACAGCTTCATACTCAAGCACTGGTGACCGTCAATGTCCTCTGTGTGGCCTCATCATGGCACCTTCCACTTCCCTCAAGAGACACATAATTAGTCTACACTCATCTGCAGGAGAGGCCCATGAAGCCACTTGCCCGTTCTGTTTCAAAGTGTTCAAAAACAAATACACTATGTGGAGTCATCGCAGCAAATTCCATTCCTatGCAGAGGATGTGGATCTAGGTCGTGTGGAATACCGCAAACTTGGAGACAGATTTCAGTGTGCCTCTTGTGATTGCTCTTATGCCAGATTACTTAATTTATCCAGACATATTGCTTCGAAACACATTCAAAATTACAACGGTATGTTCATGTGCTTTACGTGTCAGCGTTGGTTCAAAACTAAGTGGAGTTTGGCAACACACAACAGCCGTTTTCATCGAGCAAGCACAGACGGATCAGGATTGCAAGAATTAGACCAGCAACAGCTTCCCAACTTAAAATGTGAGTCGTTTGATCCTCTACAGAATCCAACAAATGATGTAATTTTACCAATGTAA
Protein Sequence
MGSQQYSLRWNNYLRHITCAFDSLRSDKDLVDVTLSCDGQKVQAHKMLLSACSSYFRDLFKENPCQHPVVIFRNVRFEDLLALIDFMYQGEVNVEQEQLASFLNTAELLQVQGLTNSNSENNTMTDDSHTNTEPKLDVPPPEVQFEGDDRSPRFLREDSPISTKPSTSSAPAAKRRRTDGGSDIGKRSCSPPVEITPMKMEAPDYVEEEDQGDREDTTEDTLARLRENDELLLTKSSSNQRLDPHSFGTSSITHPMDILHTTDTEALATAGPSSDGHSQDGLQGSLIPGPSPSQAANFIERSRSHTGYSCRLCGRTFNHRDSCQKHMAMHLGTSKCYVCSYVLSRKSHMKRHLKHVHGIDQDSFATHYPDSSPSDASSVLTILRNNSRLFVCSFCNREFKHRVSCHQHLALHKGTSKCHICNCVLSRKSHLKRHLKTIHGICSSRQYRLAPPSSHKLPPAQLIPIRQQKTPSLKNLIVSGADDSFMCMVCGRAFKDRKSCHRHMSMHLGTSTCPICFSILTTWINGSGGGQQPAAVAAATAQTYEKVCSQCGKEFKHYMSLVMHRQVHIGLTTCSICGKVFNRMYDMKKHMKAKHSHQHTDWQAVTAMATAVENLKHYFLLTDGWLPALPQAQDSEVLPPEWCGITPSTAPEFVIEHDSKKTFRCSLCNMEYKSQSSLNCHMHSHTNKSRCPVCGSLLNRIYDLRRHLINTHKLEPRPVLSGSKLHLPTASYSSTGDRQCPLCGLIMAPSTSLKRHIISLHSSAGEAHEATCPFCFKVFKNKYTMWSHRSKFHSYAEDVDLGRVEYRKLGDRFQCASCDCSYARLLNLSRHIASKHIQNYNGMFMCFTCQRWFKTKWSLATHNSRFHRASTDGSGLQELDQQQLPNLKCESFDPLQNPTNDVILPM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00651035;
90% Identity
iTF_00651035;
80% Identity
iTF_00651035;