Basic Information

Insect: Ennomos fuscantarius
Gene Symbol: ZEB2
Assembly: GCA_905220475.1
Location: HG992053.1:1539282-1558413[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.0028 0.27 12.5 3.0 1 23 431 453 431 453 0.99

2 10 0.0099 0.93 10.8 0.5 2 20 461 479 460 482 0.92

3 10 9.5 8.9e+02 1.4 0.3 1 10 486 495 486 500 0.78

4 10 0.0013 0.13 13.5 0.4 3 23 518 539 517 539 0.96

5 10 6.2 5.8e+02 2.0 1.7 2 19 552 569 551 574 0.89

6 10 0.081 7.6 7.9 4.2 1 23 614 637 614 637 0.93

7 10 1.6e-05 0.0015 19.5 1.4 1 23 653 675 653 675 0.96

8 10 0.0011 0.099 13.8 2.7 1 21 681 701 681 703 0.95

9 10 1.9e-06 0.00018 22.5 0.4 2 23 709 730 708 730 0.97

10 10 6.8e-07 6.4e-05 23.9 0.5 1 23 736 759 736 759 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.0028	0.27	12.5	3.0	1	23	431	453	431	453	0.99
2	10	0.0099	0.93	10.8	0.5	2	20	461	479	460	482	0.92
3	10	9.5	8.9e+02	1.4	0.3	1	10	486	495	486	500	0.78
4	10	0.0013	0.13	13.5	0.4	3	23	518	539	517	539	0.96
5	10	6.2	5.8e+02	2.0	1.7	2	19	552	569	551	574	0.89
6	10	0.081	7.6	7.9	4.2	1	23	614	637	614	637	0.93
7	10	1.6e-05	0.0015	19.5	1.4	1	23	653	675	653	675	0.96
8	10	0.0011	0.099	13.8	2.7	1	21	681	701	681	703	0.95
9	10	1.9e-06	0.00018	22.5	0.4	2	23	709	730	708	730	0.97
10	10	6.8e-07	6.4e-05	23.9	0.5	1	23	736	759	736	759	0.96

Sequence Information

Coding Sequence: ATGTACAATTTTAAACAGAAATGTGTTATCGCCTCTAACATTTTAAAGTCTTGGAGGGCATCTAAATTAAAGGAACCCCTAAACACAATACACGAGAAACTGCCTCCAACTTCACTTGGGCTCTGGATTCCAGATAATGCCAAAGTCTTCTATTATGAAGAGGGAGAATTTGAAACAAAAACAATTAAATTAGAAGACGATCTAGAAATAGATGAAGATATACAATATGATGAATTAGTAGAGATAAATAATGATGTACAACATTATGAAGTTCCACCGAGTAACGAAGTACCAGAATCAAATAATAATACACCATCAATACTTGAAGCTACATTAACAAACATAGGGCCAAGATTCAGTAAAAATACATCAATATGTGCAGTAAGACCAAGTAGTATAGATGTATTAGAAAATATGAATGTACCAAATGAGACAAAGCAAGCACCGGTGTTGTGGAAATATTTATCCAGAAATGAAGTAACACCTAATCTACAAGACACAAAAAGTAATACTGAAGCTCTATCAAATATGCCAAAATCAGAATTGACACAAAGTTTAAATGAATCAAAAGAAATTGGTCAAAGCTACACCACATCAAATACAGAACAGACAGCATCTGCATTTGATACAATCATCATGATTACTGTGAACTTGAGGGTGTACCGCAACCACGTACATCGAGGAAGAGACCGCGAGCGCGTGAGACTTTTAAACGGGGAAAAAGTACGAGAAAACCAAATGCTCGTAAGCTTTAAAGTATTGTTAAGAGAATATTTTTCTTTATGTGGCGAGCTCAAAACCTTCAACGGTACAACCATAGACAAAGATTTTATATTAAGTCTTGTGGACCACAAGCTGTCGGAGAGGAGAATGCGGATGCTCTGGAAACTAATATACGAATACGACATCACACTCGACACTACATTCGCGACGATCAAACTGGAAACGACTAAATTGCATGAGAGAGCACGTGCGACTGAGTGTAAGCCGCGGGCCGCGCCGCGCCTATGCCGAGTGATGCCGCGCCGCCCGCGCACCCCATTTCCCCGTAGGCACACAGGTGCAGGAGCGGCATGCTACAAAAGAGCCGACAAAGGCGGCCCCCGTTTGTCGGTTCCGCATACAACTAAAATGAAACCAGGCGTAGTTCGCCTTCTAGGATTGATACAAAACTCATACAAAAATGAAGAATACGAATCTGTGTTTAACATAGTATATCTGAACACAGAGGAGGATGTGCGAAAAGAGTTCCAGAATAGGAAGACGTACAAGTGCTACACGGGCGCGGAGTTCAAATGCGAGATATGCTACGAAGGGTTTACGCACGAGAAGCGGCTGATTTACCATCAGAAATCACATGACGAGAGTACGGGTAACGTCGTATGTGATATATGCAGCAAACGGTTCAACAACAAAAAGAGATTGTACATTCACCGACCCCTGCACGAGATTGTCTTCAAATGCAAGCTGTGCCCAATGGTCACTTTCTACAGAAGCATGTCCGTTTTCGTCACACACTGCAATAACTTCTGCAAGGGTGCCCCTAACTTTTGTACTATCTGTGGACGGAAATTCGTCAAGGAATCGGTGCTGAAGTTGCATTTGGCCAAAGATCACAAGGACGAGCCCCCAACTGATCCCGAGAACTGCGTACAGTGCCCGCACTGCATGGTCGGGTTCAGTACAGAACGAGCAATGTATAGGCACTGTCTCAACACACACGGCAAGCAGCATTGGTCAGTAACGTCTACTAGTAAAGCACCATTAAAGAAAACTCGGAAGGAAAGGGCACCTCATCCTGAGAAAGGGGATAACCCTAGGAAACCAATAGATAGAAGACACACTTGTCAATTGTGCAACGAAGTCTGCGAAAACAAGTATTGGTTGAAAATGCATTTCACCGTGAAACATCCACTATTGGATATGGAATCCTTTTTATACCCAACTCCGCAACCGTATCTGTGCCACATTTGCGGAAGGTCGTTTAAGGTTTACAGTGCTTTATTTGATCATTTGAATTCTCATTCGGGCAAGCGACCGTTCGAATGTCCCGAGTGCCGTAAACGTTTCCAGCGCAGCGTGGGCCTGGCGCACCACATGCTGTGCCACCGGCCCCCGGACCAAGTGTGCTATGTTTGCGGGAAAATGTTCAAAACTAAAGTCAATATGATGATCCATATGCGGATCCACAAAAACGATCGTCGCTACAAGTGTCATATTTGCGGGAAAGGCTTCATTCAATCTTACGCGCTTAAAGAACACGTCAGAGGGGTTCATGAGCAAATCAGACGCCCTAGAAAGACTCCGAGAAAAGCTCCTGAAGCGAAAAAGATAGCTTACAGCGGAAATAAACGCGACGGGAATGCTTTGAGTGAACCCGTGAGAGGTGTTCGTCAGAAAATACGACGCGTTAAAAAGAAACGCGACGAGATCGCTCCTGAGACGACAGAGTTGGTTTATAGCGGGAATGAAAGCGACGGGAATTCTTTGAGTGAACACGTGAGAGGGGTTCATCGGGAAATACGACGCGTTGAAAAGAAACGCGACGAAATCGCTGCAGAGGCGACAGAGTTAGTTTATAGTGGGAATGAAAGCGACGAGAATGCTTTGAATGAACCCGTGAGATGGGATCATCAGAAAATACGACGCGTTGAAAATAAACACGACGAGTTCGCTCCTGAAGTGACAGAGATAGTTTATAGTGGGAATGAAAGCGATGAGAATGCTTTGAGTGAACCAGTAAGAGGGGTTTATCAGAAAAAACGACGAGTTGAAAAGAAACGCGACGAAATCGTTGCAGAGGCGACAGAGTTAGTTTATAGTGGGAATGAAAGCGACGAGAATGCTTTGAGTGAACCCGTGATAAAGGTTCATCAAAAAATACGACGCGTTGAAAATAAATTCGATGAGATCGCTCTTGAGACGACAGAGTTAGTTTATAGCGGGAACGAAAGCGACGAGAATGCTTTGAGTGAACCCGTGAGATGGGATCATCGGAAAACACGACGTGTTGAAAAGAAACACGACGAGATCGCTCCTGAAGTGACAGAGTTAGTTTATAGTGGGAATGAAAGCGACGAGAATGCTTGGAGTGAAGAGTCTACTCAATAA
Protein Sequence: MYNFKQKCVIASNILKSWRASKLKEPLNTIHEKLPPTSLGLWIPDNAKVFYYEEGEFETKTIKLEDDLEIDEDIQYDELVEINNDVQHYEVPPSNEVPESNNNTPSILEATLTNIGPRFSKNTSICAVRPSSIDVLENMNVPNETKQAPVLWKYLSRNEVTPNLQDTKSNTEALSNMPKSELTQSLNESKEIGQSYTTSNTEQTASAFDTIIMITVNLRVYRNHVHRGRDRERVRLLNGEKVRENQMLVSFKVLLREYFSLCGELKTFNGTTIDKDFILSLVDHKLSERRMRMLWKLIYEYDITLDTTFATIKLETTKLHERARATECKPRAAPRLCRVMPRRPRTPFPRRHTGAGAACYKRADKGGPRLSVPHTTKMKPGVVRLLGLIQNSYKNEEYESVFNIVYLNTEEDVRKEFQNRKTYKCYTGAEFKCEICYEGFTHEKRLIYHQKSHDESTGNVVCDICSKRFNNKKRLYIHRPLHEIVFKCKLCPMVTFYRSMSVFVTHCNNFCKGAPNFCTICGRKFVKESVLKLHLAKDHKDEPPTDPENCVQCPHCMVGFSTERAMYRHCLNTHGKQHWSVTSTSKAPLKKTRKERAPHPEKGDNPRKPIDRRHTCQLCNEVCENKYWLKMHFTVKHPLLDMESFLYPTPQPYLCHICGRSFKVYSALFDHLNSHSGKRPFECPECRKRFQRSVGLAHHMLCHRPPDQVCYVCGKMFKTKVNMMIHMRIHKNDRRYKCHICGKGFIQSYALKEHVRGVHEQIRRPRKTPRKAPEAKKIAYSGNKRDGNALSEPVRGVRQKIRRVKKKRDEIAPETTELVYSGNESDGNSLSEHVRGVHREIRRVEKKRDEIAAEATELVYSGNESDENALNEPVRWDHQKIRRVENKHDEFAPEVTEIVYSGNESDENALSEPVRGVYQKKRRVEKKRDEIVAEATELVYSGNESDENALSEPVIKVHQKIRRVENKFDEIALETTELVYSGNESDENALSEPVRWDHRKTRRVEKKHDEIAPEVTELVYSGNESDENAWSEESTQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -