Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00047 0.046 15.4 0.3 1 23 64 86 64 86 0.97

2 6 1.2e-05 0.0012 20.5 3.2 1 23 93 116 93 116 0.97

3 6 1.9 1.9e+02 4.0 1.2 8 21 124 137 124 138 0.91

4 6 0.00051 0.051 15.3 3.8 1 23 146 169 146 170 0.95

5 6 9.2e-05 0.0091 17.6 4.7 1 21 212 232 212 233 0.95

6 6 0.0004 0.04 15.6 5.2 1 23 241 264 241 264 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00047	0.046	15.4	0.3	1	23	64	86	64	86	0.97
2	6	1.2e-05	0.0012	20.5	3.2	1	23	93	116	93	116	0.97
3	6	1.9	1.9e+02	4.0	1.2	8	21	124	137	124	138	0.91
4	6	0.00051	0.051	15.3	3.8	1	23	146	169	146	170	0.95
5	6	9.2e-05	0.0091	17.6	4.7	1	21	212	232	212	233	0.95
6	6	0.0004	0.04	15.6	5.2	1	23	241	264	241	264	0.93

Coding Sequence: ATGCGTAAGAAGAATCAGTTTTGCCGTGACACAGTTCAGCATGTTTTGAACTCCTGCTCAGCGCTGGTGGCGCAGGCCAAGTTCCAGCAGCGCCTGGCGATGGAGCTGCTGTCGATGCGGCTGAAGGTGGGCGCAGTGCCGTGGGGTGAGGAGATGGAGGACCGCAGCAAGGTGGGGGGCGCAGCACCCTACGCGTGCCCGGACTGTGGCAAGACCTACATGTGGAAGCAGGGGTTGAACACACACAAGAGACTGCACTGCGGGAAGGAGCCTAGGTTCCAGTGTCCGCACTGCCCCAAGCGCTGCTACCAGAGGGGCAACCTGGACAGTCATATACGGAACGTGCACATGCTGCCGATACTCAAGATGAAGAGATACCGGCACCAGCGAAGTCTGCGGAAGCACGAACGTCTCGAATGCGGCAAGTCACCCCAGTACCACTGTCCTTTCTGTGAGAGAGCCTTCCACCAGCGCGGGAACCTGAAGATCCACGTCGCCGTGAAGCATCATGCGTGTGAGGAGGCCTCACACGAGCTTGAAGGAAGCTTGTTGGGTCTTTTTACTCCTCAAGAAGTATTTGAGCAAGAGATGGTGGGATTCTCTTCCTCCCCGAGCGGTGATCTTTCCGTCAAGTTTCCGTGTCCGCAGTGCAACCGTAGTTACCGGCACAAGTGTGATCTCAAGCGACATCTCAAGTTCGAGTGTGGGCAACAGCCGAACTTCCTCTGCGTCCACTGTCCCCGCAGATTCCACCAGAAGACAAACCTGAAGAGACATGTGTTCACGGTGCACTCGGCTCTGCTCGCGTCGTCTGCAAACGGAGACATCGATCAGCTGATGGAGTTGAGTCTGCCGTCGCTCCTCTGA
Protein Sequence: MRKKNQFCRDTVQHVLNSCSALVAQAKFQQRLAMELLSMRLKVGAVPWGEEMEDRSKVGGAAPYACPDCGKTYMWKQGLNTHKRLHCGKEPRFQCPHCPKRCYQRGNLDSHIRNVHMLPILKMKRYRHQRSLRKHERLECGKSPQYHCPFCERAFHQRGNLKIHVAVKHHACEEASHELEGSLLGLFTPQEVFEQEMVGFSSSPSGDLSVKFPCPQCNRSYRHKCDLKRHLKFECGQQPNFLCVHCPRRFHQKTNLKRHVFTVHSALLASSANGDIDQLMELSLPSLL*

Sequence clustering based on sequence similarity using MMseqs2