Basic Information

Gene Symbol
Bcl11a
Assembly
GCA_015832385.1
Location
JACTOM010000178.1:113763-128301[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 6.3 5.1e+02 2.1 0.2 2 23 222 243 221 243 0.92
2 10 1.9 1.6e+02 3.7 6.2 2 23 249 271 248 271 0.95
3 10 0.033 2.7 9.3 0.5 1 23 275 298 275 298 0.95
4 10 4.7e-06 0.00038 21.4 0.8 2 23 302 324 301 324 0.96
5 10 0.0016 0.13 13.4 1.3 2 23 328 350 327 350 0.95
6 10 0.094 7.6 7.9 0.3 2 22 364 384 363 388 0.92
7 10 6.1e-06 0.0005 21.0 0.2 2 23 397 419 396 419 0.94
8 10 0.054 4.4 8.6 3.6 1 23 425 448 425 448 0.92
9 10 0.00031 0.025 15.7 1.3 3 23 459 479 458 479 0.98
10 10 0.00076 0.061 14.5 0.4 1 23 485 508 485 508 0.98

Sequence Information

Coding Sequence
atggaTCCGGTGAAAAGTGAAATAGACAATATATGCCGTGGATGTTTGTGCGTCGATCGCGTTCTCATGCCTCTGAATAAAaatgttgatttattttttattttcttaggCAATGAACTATCCATAGCAGAGAATAGCACCACCACAGTACAATGTCTTTCAAACTTATGCACATCCAAAAAGGAAGACTACGATCATATATTCTTAGAAACCGAGGAGTTTGACCatgaaatatcaaaaataaaaccgGAATCACTCAAAATTGAAGAGAATTTGCAATTCGAAAACGAACTCGCCATTGCAGACGAATACCACATAAAAGAAGAGAATTATGACGACAATAGTATGGAATATGAAGACACTGTGGAGATCCAACCAGATGTGTCAGATAATTGTGTGAAAAAAGAGAAAAAGACGCGTAATTACAAAATCCAAGCGTTAGGCAAAAGGATCAAGACGACTACGGTGAAGTACGCTAAAGAAGAAATGGACAATTATATAGAAACAATCAACAGTACCTTGAACGATATTCTGGCGATGGAAAAGGACGAAAAAAAACCCGGTAGAATAAAGAACATGGAGCATCGGTGTAATCTTTATATAACTAAGTTGttagatataaagaaaaaacatatttctaaaaGACAGAAGGCTGAAGGCATATCATGCTCCGAATGCTGCATAGTGTTGCCAGACCAAGAGGCTATGAAACAGCATTGGGAGAATCATCCTGTATCTTTGTCTAAATGTCACTTCTGTGGTTGGTTGAGCAAATCCAGGTGTAATATCATACATCACATTCAGCAAAGACATTCAACTATATATAATTGCACTTTGTGTAACATTGAATTTAGAGCCTTACCGGAATACTACCGCCATTATAGGGATCTTCACAGGACTCTCATATGTGACTACTGCGGGAAGCGTTTCCAACAGAAAAGCGGGATAGAAAGACACATAAGACGCAAACATCTACCGATGAAATGCGAAATATGTAAGCGGGTTTACAAAAAGGTGGCGTTTTTAAACAATCATATGGCGATCTGCCACCCGGATGTCAAATGGAAGACCATAAAACGTGAGCTAACTTACTGTGTAGAGTGCGACGTGCATTTCCCAACAGAGTATATATACAAACGTCATCTTAGGACAGCAATCGCTCATCGTCCTAAACTGAAGATCAAGGTGCCTTGTCCGGATTGTGGTAAGATATTCAGCAGGAAGAGTTATATGGACAACCATTACAAACTGGTGCACGTCAGGAAGTCACAGCATTATTGCGAAATTTGCAATAAGcATTTCATAAATGGGTACGCTATTAGGACACACAAAAAGTTCGTCCACGATAAATACGAGAAGCCGAAGAACAAAATATGTGATATATGCGGACGTGGGTTTCATACAAATCGAGTGTTAATCAACCACAAACGCACTCATACTGGAGAGAGGCCATACAAATGTACTTACTGCCCCGCTGCGTTTGCACAAAACGTTGCACGAAAAACACACGAAAAGACACAACATAAAAACCTTATCACTGAACTTAAGGGTTTTTCCACATAA
Protein Sequence
MDPVKSEIDNICRGCLCVDRVLMPLNKNVDLFFIFLGNELSIAENSTTTVQCLSNLCTSKKEDYDHIFLETEEFDHEISKIKPESLKIEENLQFENELAIADEYHIKEENYDDNSMEYEDTVEIQPDVSDNCVKKEKKTRNYKIQALGKRIKTTTVKYAKEEMDNYIETINSTLNDILAMEKDEKKPGRIKNMEHRCNLYITKLLDIKKKHISKRQKAEGISCSECCIVLPDQEAMKQHWENHPVSLSKCHFCGWLSKSRCNIIHHIQQRHSTIYNCTLCNIEFRALPEYYRHYRDLHRTLICDYCGKRFQQKSGIERHIRRKHLPMKCEICKRVYKKVAFLNNHMAICHPDVKWKTIKRELTYCVECDVHFPTEYIYKRHLRTAIAHRPKLKIKVPCPDCGKIFSRKSYMDNHYKLVHVRKSQHYCEICNKHFINGYAIRTHKKFVHDKYEKPKNKICDICGRGFHTNRVLINHKRTHTGERPYKCTYCPAAFAQNVARKTHEKTQHKNLITELKGFST*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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