Basic Information

Gene Symbol
-
Assembly
GCA_947095575.1
Location
OX352714.1:3964872-3969483[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 2.9e-05 0.0014 19.1 2.4 2 23 171 192 170 192 0.96
2 14 0.00013 0.0064 17.0 1.8 3 23 200 220 199 220 0.98
3 14 0.00041 0.021 15.4 0.1 1 23 226 248 226 248 0.95
4 14 0.0014 0.071 13.7 3.4 1 21 254 274 254 276 0.94
5 14 3.5e-05 0.0018 18.8 3.0 1 23 282 304 282 304 0.98
6 14 5.1e-06 0.00026 21.4 0.5 1 23 310 332 310 332 0.98
7 14 0.19 9.3 7.1 0.5 1 20 338 357 338 359 0.90
8 14 9.3e-07 4.6e-05 23.8 2.8 1 23 386 408 386 408 0.98
9 14 3.3e-05 0.0016 18.9 0.7 2 23 415 436 415 436 0.97
10 14 3.4e-05 0.0017 18.8 3.6 1 23 442 464 442 464 0.99
11 14 1.5e-08 7.7e-07 29.4 0.9 1 23 471 493 471 493 0.98
12 14 1.8e-05 0.0009 19.7 0.1 1 23 499 521 499 521 0.95
13 14 1.6e-05 0.00078 19.9 3.5 1 23 527 549 527 549 0.99
14 14 0.0083 0.41 11.3 3.3 1 23 555 578 555 578 0.97

Sequence Information

Coding Sequence
ATGAGCATAGCCCTTTGCCGAGCGTGTCTAACTGAAAATGCAAAAATGCAGGCCATCCGCGACACCCAACTTCATGAAGTCTACGAAAAACTGTCCAACTCTAAGCTTATAACAGAGGATGGAAGGCCTGATACAGTTTGCTACACTTGCTACTCACAGCTGCAAAGATGCCACAACTTTTCCGTTATGAGCCAAAAAGCTAACAAGTTACTTAAACAAAAGTATTGTGATGGCATTGAGATATCACAAGTAGATGTTTCTACACTACCTGAAACCTCTAACTCATTGGGCTCTTTGAAGAATTCTCCGGTCGATTCTCAACCACAAGACAATAAAGCTTGCAATGGAATTAAAATAGAATGTGATTCTGTTAAAACAGAATTAGTTCAAAGTGATGGAAGCTTCTGTGACATCAAAATAGAAGATACAAATAGCAATGACATCACAAGTTTAGAAGCATCAACGAAGAAATCAGTCAAGAAAAAAAAAACTTTTCgcgaaaagtcttgtgtctgtgataagtgcgataaaaagttcgcaaacgaaacatatttaaaagcacacgaaaagacccatagcgaagaaaagacaagtgcctgtgacaggtgcggtaaaacgtttcttgataaatatcgattgaagagacatatgaaatctcacacaggagaaaaaccatatgcttgcgaccaatgtgccagaacttataaagatataggcaacttgagaaaacatatagcggaccatacaggcgaaaagccacacatttgcacggaatgcagcgcgtcgttaacacgaaagggaagtttgcaacggcatatgagatgtcacactggggaaaagccttattcttgtgatgtttgtcaaaaatcaatgtctacaatgactcatttgaaaaggcatatgagaatccacacaggcgaacggccatacccatgtgatgtatgcgggaaggcatacgccgataaagacgattgcaaaaggcacatgcgaatacactctggagaaaaaccatacttatgcaacatttgtgattataaaagttttttcaagaaagctttaaagttgcatttaggaaACTTACAAGAACACGATCATAACAAGAAAAGTACGACACATGTAGATCAGCCACAGAAGAATCCGATAAGAAAGTCATTGtacagttgtgatatgtgttttaaaacatttgcacataatactaacttaaaagcacatatgaaaattcacattggagagaaattgaatgtttgtgatagatgcggaaaatcattcctaagtgcatatcagttaaaaaggcatgtgcgatctcacaccggagaaaaaccatataaatgcaatttctgttatagaacattctcagacaaaggtaaccaaacgaaacacgttcgaagtcattcagaaaacaaccgttcattcgtctgtacggaatgtaacgcatcattttcccaaaaaggcaacttacagcgccatatgagatctcacaccggagaaacgccatttttatgtgatatctgtctaaaatcactacccgatgctagtttgttaaaaagacacatgagaattcacacgggagaaaagccatacgtgtgtaacacgtgtggcaaagcatactctgataaggataactataaatgccatatgagacgtcacactggagaaaagccatatgtttgtaaattatgtgaTTACAAGTGTGCTTATGCGACTAGCTTGAGATATCATTTATCTAAAAAACATTCTGAAAACCAGTAG
Protein Sequence
MSIALCRACLTENAKMQAIRDTQLHEVYEKLSNSKLITEDGRPDTVCYTCYSQLQRCHNFSVMSQKANKLLKQKYCDGIEISQVDVSTLPETSNSLGSLKNSPVDSQPQDNKACNGIKIECDSVKTELVQSDGSFCDIKIEDTNSNDITSLEASTKKSVKKKKTFREKSCVCDKCDKKFANETYLKAHEKTHSEEKTSACDRCGKTFLDKYRLKRHMKSHTGEKPYACDQCARTYKDIGNLRKHIADHTGEKPHICTECSASLTRKGSLQRHMRCHTGEKPYSCDVCQKSMSTMTHLKRHMRIHTGERPYPCDVCGKAYADKDDCKRHMRIHSGEKPYLCNICDYKSFFKKALKLHLGNLQEHDHNKKSTTHVDQPQKNPIRKSLYSCDMCFKTFAHNTNLKAHMKIHIGEKLNVCDRCGKSFLSAYQLKRHVRSHTGEKPYKCNFCYRTFSDKGNQTKHVRSHSENNRSFVCTECNASFSQKGNLQRHMRSHTGETPFLCDICLKSLPDASLLKRHMRIHTGEKPYVCNTCGKAYSDKDNYKCHMRRHTGEKPYVCKLCDYKCAYATSLRYHLSKKHSENQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-