Basic Information

Gene Symbol
-
Assembly
GCA_963662185.1
Location
OY759255.1:16806626-16812457[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 8.6e-05 0.011 17.5 3.6 1 23 188 210 188 210 0.98
2 14 0.33 43 6.2 2.2 2 23 214 235 213 235 0.85
3 14 0.004 0.52 12.3 1.7 1 23 240 263 240 263 0.93
4 14 9.8 1.3e+03 1.6 0.8 1 8 289 296 289 305 0.90
5 14 0.97 1.3e+02 4.8 1.5 3 19 321 337 320 342 0.90
6 14 0.65 84 5.3 5.1 1 20 348 367 348 369 0.95
7 14 0.086 11 8.1 2.0 1 21 378 398 378 399 0.87
8 14 7.2e-05 0.0092 17.8 3.3 1 23 407 430 407 430 0.97
9 14 0.68 88 5.3 0.5 1 10 435 444 435 460 0.78
10 14 0.029 3.7 9.6 0.3 2 23 468 489 467 489 0.96
11 14 1.4 1.8e+02 4.3 3.0 1 19 495 513 495 516 0.92
12 14 0.12 15 7.7 0.2 2 23 523 543 522 543 0.94
13 14 0.00013 0.017 17.0 1.2 2 23 549 570 548 570 0.97
14 14 0.21 27 6.9 1.0 2 23 575 595 574 595 0.94

Sequence Information

Coding Sequence
ATGGAGAACTGGAAGTTGAAACTGACGCGTATTCTGCACGAAACGAAGTTCTGTGGTATCTGTTTGAACGCTGAGGATGGCATGAACGCGATCAGTGATGAACTAGAGATAGTTCACTGTGAAACAACTTATAAGAACACATTGCGGCATATTGTGGACAGAGTGTTTAAAGAGactgACTATCCACTAGCTAATTCACAAGTATGCGAGAGTTGTACAAAGAAACTCATTCAGTCATATATGTTCATACGAAACGCCGAAGAGACGGCGAAATTGCTGAATTTTCACTTGAATGagttatattataaaacgtGTTACATACGTAATAATGATTTGAAACATAAACAAGCCGGTTCTGAGATATATAACGTTGTTATTGCATTAGACAAAGAAATACCGAAAGGTTTTGACTGTGATATTGCGCCAGAAGAGCCCAAGACGGCTGAAAGTAATCGAAGTCATCCCAGAGCCAAACGAAAACTGAAGTGTGTTAGTTGTAATGTGATACTACCCTCACAAAGAGCGTGGAGGGTACACGATACAAACACTCACAAGAATAATCACAGATGTCCATTGTGTCTGCAGAGTTTCAGAACGCGTCAGGACTTTACTGCACACTATAGGACGCATTTGAAGTTACGATGTACGATTTGTCACAAAACAGTTCGTGATGGAAGACTGCTGCAGCATCTGAAGCGACGTCACAGACATTCCGTGTATTTGTGTTCAACCTGTGATGTTGCTTTCTATAGCGCCAAAACTTTGGAGAGGCACAACAGAGAGTGTCATTATAGCACCGACTCTAGATGTGTAACATGTCTCCACAGTTCGTCCCTTGGCTCGTTACAGCAGCACCGGTGCAGGTTCTCGTGCCCCGAGTGCGACGAGGCGCCTTGTGTGCACCACGAGCACTTGATGTCGTACAGAGCGCAGGCGCTGAACCTCGCAGGCAGAGCCGCGTGCGCACGCTGTAGCTACGTGTGCACCACCAAGGAGGCGCTAGTAGCGCACTGCAATGCACTACACTTGAAGGTTCAGCCGTACCGCTGTGAGAGGTGTACGCAGAGGTTTTATTGTAAATCGGACTTGACGAACCATGTTTGCGAGTCGAAGCAAACGAAAAAAGGTGTCCACGTTTGTGAATATTGTGACAAGCAGTTCAGTGTAGAGGTGATGTGCCAACGACATAGAAAGGAGTGCGGTCGCATTCAGCGACAGCACCAGTGCGATTATTGTCCCGCGAATTTTGATTCGTCGAACAATCTCACAAAACACAGAAAACGCAAACATGGTAAACATGCGTTTTCGTGTAACTTGTGCGACAGAGTTTTTTTAAACGTCATGaagaaaagaaaacatttcCTGCAAGTTCACAGCAGACACGTAGAAAGAACTAGCTCAGAGTGTGTGGTGTGTCGAAAAAAGTTTCTATCTAAGGCAGCTCTGCTGCTACACTTGAGATATCATGAATCCGGCACAAAGTTCCCCTGTAAGGGCTGTAGGACTCAGTTCGACACTGTGAGACAATTCAGTACTCACAATTGTAAACGTGTGCGTTCATTGACGATGTGTGAGATGTGTGGTCAGCTGGTGAGACAGGTTCAGTTGAAGCAACATGTAAGAGCGCACGCGGGCGGCGCAGTGACGTGTGACACGTGCGGCAAGTCCTTCCAGAATGTGACGTCACTGCAGTATCACCGCCAGCGGCATCTGAAGAACGTATCGTGTGGTAAATGTAACAAGTCGATTAGTTCCGCGAAGTTTTGGAGGCACTTTAGGAACCATCTTATTAAAGACTCCTTTCAACAGAAACTCACGTATTAA
Protein Sequence
MENWKLKLTRILHETKFCGICLNAEDGMNAISDELEIVHCETTYKNTLRHIVDRVFKETDYPLANSQVCESCTKKLIQSYMFIRNAEETAKLLNFHLNELYYKTCYIRNNDLKHKQAGSEIYNVVIALDKEIPKGFDCDIAPEEPKTAESNRSHPRAKRKLKCVSCNVILPSQRAWRVHDTNTHKNNHRCPLCLQSFRTRQDFTAHYRTHLKLRCTICHKTVRDGRLLQHLKRRHRHSVYLCSTCDVAFYSAKTLERHNRECHYSTDSRCVTCLHSSSLGSLQQHRCRFSCPECDEAPCVHHEHLMSYRAQALNLAGRAACARCSYVCTTKEALVAHCNALHLKVQPYRCERCTQRFYCKSDLTNHVCESKQTKKGVHVCEYCDKQFSVEVMCQRHRKECGRIQRQHQCDYCPANFDSSNNLTKHRKRKHGKHAFSCNLCDRVFLNVMKKRKHFLQVHSRHVERTSSECVVCRKKFLSKAALLLHLRYHESGTKFPCKGCRTQFDTVRQFSTHNCKRVRSLTMCEMCGQLVRQVQLKQHVRAHAGGAVTCDTCGKSFQNVTSLQYHRQRHLKNVSCGKCNKSISSAKFWRHFRNHLIKDSFQQKLTY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-