Basic Information

Gene Symbol
-
Assembly
GCA_017562165.1
Location
chr31:11826395-11863900[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.036 2 9.1 4.0 1 23 476 499 476 499 0.97
2 12 0.0037 0.21 12.2 0.8 1 23 506 528 506 528 0.97
3 12 0.077 4.3 8.0 1.3 1 23 532 554 532 554 0.97
4 12 0.0022 0.12 12.9 2.9 1 22 560 581 560 583 0.88
5 12 0.024 1.3 9.6 0.2 1 23 588 611 588 611 0.95
6 12 0.0029 0.16 12.5 0.5 2 23 624 646 623 646 0.95
7 12 0.35 20 6.0 2.6 2 23 658 680 657 680 0.95
8 12 1.7 98 3.8 0.1 2 23 690 711 689 712 0.94
9 12 7.2e-06 0.00041 20.7 0.4 3 23 729 749 727 749 0.96
10 12 9.4e-05 0.0053 17.2 0.2 2 23 755 776 754 776 0.96
11 12 2.1e-05 0.0012 19.2 4.2 1 21 781 801 781 803 0.96
12 12 4.6e-05 0.0026 18.1 0.4 1 23 809 832 809 832 0.97

Sequence Information

Coding Sequence
ATGATGGAGTTTAATGATATATGCCTCATTTGTTTACGGACcgatagaaaattaaaaactgcACCCGCAGCATTATCGAAATACCACTATGAAATGACAAATCACTGTtTTGATATCaaacagttaaattactgtTGTATTTGCGAGCATCTCCTGAGAAAAGCTTATAAGTTCCATCAAAAATGTCTGACTGCAACAAAAGTATTGAAGAATTGGGAAAACTCTACAGCACCAAACAAAACCCCTATAGATCAGCTCCACCTGAAGTTGTTCTCCCTGGGTACCCTGGGTCCGTGGACCGCTGACAACAACAAAGTATACTTCTATAATGCACCTGATGAAGATGCAGGAAACTCATTCGTTGCTCCTATTAAAgtaCCAAAGTTAGAAATTATACCATTATTAGAGACCCCAGCAGTAGAGATTAAGCAAGAAATTGAATGTGATTTAGAAGAAACTAACATAGAAGCTAATGTAGATCCACAATATACCATTGACAATATAGAAGTCAAGGAAATAAAGTATACACCAGATGATACATATTCAATAGAAGTAACAAACACAGATAttggaaacaataaaaaagttcaaaaaactTTGAATACACAAAGAAGAATTAAACATGACAGAGATGTAAAGGTTGAAGAAACTGAATTAGAAGATGATACCATGTATTTAAGCGATGATGATTGCAATGATGATACTATTGAGGAAGTTAAACAACTTGATTATACAAGTGGAAATGATGATAATGAAAACATAGCAAATAATGACACGAGTGACGATGATTCAGAGGACAAAGATGATGCAGAAACAAAACCAATTGCTCTAAAGATTATGTCCACGATAAGAACtttaaatgaaacattggcagGCATTTGTCAAGATTATTATATACCTGCTTTGACTCACATGGCGGAGGATATAACAACTGAAGAAGTTAAGAAGCTAACACATGAATATTTGGTTAATAAAATGGTTACTAATAGAAAAGTTAAAAGGAAgactataaaatttaaaattgaagggATAGATGCTGACCTTTCCACCATTATCTCTGAAAGCAAAGATCAGGTCAGAGATTTCAATGCCGATTTGACTAGTAGAGAATGCTTGCAAAGAACATACGAGCTTGGGGCGAACTTAACTCAGAGGAAGGGGAAGACATTCGATACAGAGAGTGTTATAAACTGCCTGGACAGAGTGTCTCAGAAGAATATCAAACAACTACATACCTATTTCTCTGATACGAAAAATTCACGAATTTTACCAGTGGACATAGCAAGAATTCTTAAGAATTCTGAATCCAAACTTAAAGACGAAGAATATGCGTCGGTCTTTGAAATCATATACCTGACGACAGAGAAGGCTAAAATAGAAGAGTTTCAACAACGGAAAACATATGAATGCTATCTCCAAGCCACTTTTAAATGCGACAAATGTTTCCTGAAATGTAAAAATTCTGGTCTGTTAGAGTTACACAATAAAACTAATCACGATGAAAGCAACACGAAATACATATGTCCTATATGCCCAGTACGGCGTGTGTCTAAACGGAGACTGACGCACCACATGAACTTACACGACGAAGTATTCAAATGCAAGTTGTGTCCATTGGTCACTTACTACAGaACGTCCATGATACAACATTATTTACAACACAGCGGGAAGTGCGAATATAAATGTGAGAAGTGCAATAAGACCTTCCGGAGTCTGTCAGTGTTCCTCACCCACAACTCGCAGTACCACCCCCGCGGGGCCCACATCTGCGGCATCTGCGGAGGTTCCTACATATCGCGGGTCGGCCTGAAGGGGCACATCACTAGGAAACACCCGGGAGCTCCGAAAGAGGCGGAGAGCAACGAACTGAAGTGTGGGATTTGTGATTTCACCTTCTCATCGCTAGAGGAGTACAGCGAACACTCTCGCAATTACCACAGAACGTTTGAGAAAAAAGACCTATCGCAGGTGAAGTGCGAATATTGCAAACTCTTATTCCGCACAAAAACAGAGTGCTCGAACCATTTGATGTCGGCGCACGGACTTAAaaaaaagaaaCCCGTCGTGCGTTGCCGAGTGTGCAGTGAGGTGGGAGACAGCGCGGGATGGGTGAAGCTGCATTACATCACGCACCACCCCACCGTGGACGTCGCCGCGCTCTACGCTGGCAACAAGACTCATCTCTGCGAAATCTGCGGGAAAGGATTCTCGGTCCTTGGCTACCTCCAAGATCACATGAACACCCACAAAGGCATCACAGTCCCGTGCTCGCGTTGCCCCAAGCGGTTCGCTAGCAAGTTGGCTTTGCAGCGGCACGAACGGATCCACGACCCGCCCAGGTTCACCTGCAAATACTGCGGGAAGAAGTTCTATGCGCCTTCCAATCTCAGCAATCATATGCGGtgTCACATTAGGGATCGTCGCTACAAATGCGATCTCTGTGACAAGGGCTTCCTACACAGGTCTGCTTTAACAGCACATATCCGGGGGGTGCACAACAACGAACGCCGCGTCAGAAAACCTAGACTCGCTTCACGGAGGACCAGAGACACGATGTACGTCGCAGAGACAGACGAAGCCATTGAGGCAACAAACGAAGTCACCGAAGCAATAGACGAAGCTATATATGCAACAGACGAAATGGCAGAAACAATAGAGGGAATGGACATAATAGACGAGTGA
Protein Sequence
MMEFNDICLICLRTDRKLKTAPAALSKYHYEMTNHCFDIKQLNYCCICEHLLRKAYKFHQKCLTATKVLKNWENSTAPNKTPIDQLHLKLFSLGTLGPWTADNNKVYFYNAPDEDAGNSFVAPIKVPKLEIIPLLETPAVEIKQEIECDLEETNIEANVDPQYTIDNIEVKEIKYTPDDTYSIEVTNTDIGNNKKVQKTLNTQRRIKHDRDVKVEETELEDDTMYLSDDDCNDDTIEEVKQLDYTSGNDDNENIANNDTSDDDSEDKDDAETKPIALKIMSTIRTLNETLAGICQDYYIPALTHMAEDITTEEVKKLTHEYLVNKMVTNRKVKRKTIKFKIEGIDADLSTIISESKDQVRDFNADLTSRECLQRTYELGANLTQRKGKTFDTESVINCLDRVSQKNIKQLHTYFSDTKNSRILPVDIARILKNSESKLKDEEYASVFEIIYLTTEKAKIEEFQQRKTYECYLQATFKCDKCFLKCKNSGLLELHNKTNHDESNTKYICPICPVRRVSKRRLTHHMNLHDEVFKCKLCPLVTYYRTSMIQHYLQHSGKCEYKCEKCNKTFRSLSVFLTHNSQYHPRGAHICGICGGSYISRVGLKGHITRKHPGAPKEAESNELKCGICDFTFSSLEEYSEHSRNYHRTFEKKDLSQVKCEYCKLLFRTKTECSNHLMSAHGLKKKKPVVRCRVCSEVGDSAGWVKLHYITHHPTVDVAALYAGNKTHLCEICGKGFSVLGYLQDHMNTHKGITVPCSRCPKRFASKLALQRHERIHDPPRFTCKYCGKKFYAPSNLSNHMRCHIRDRRYKCDLCDKGFLHRSALTAHIRGVHNNERRVRKPRLASRRTRDTMYVAETDEAIEATNEVTEAIDEAIYATDEMAETIEGMDIIDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-