Basic Information

Gene Symbol
gtf3a
Assembly
GCA_964023945.1
Location
OZ030376.1:18588653-18592816[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00053 0.048 14.2 0.1 2 23 692 713 691 713 0.97
2 17 0.018 1.7 9.4 0.5 1 19 719 737 719 740 0.92
3 17 0.38 34 5.2 0.9 2 23 746 767 745 767 0.95
4 17 0.00012 0.011 16.3 1.0 3 23 776 797 775 797 0.98
5 17 0.0033 0.3 11.7 2.1 1 23 804 827 804 827 0.95
6 17 8.1e-05 0.0073 16.8 0.7 1 23 833 856 833 856 0.94
7 17 1.1 1e+02 3.8 2.5 2 23 864 884 864 884 0.94
8 17 1.2e-07 1.1e-05 25.7 2.1 2 23 890 911 889 911 0.97
9 17 1.9e-06 0.00017 21.9 0.2 1 23 917 939 917 939 0.99
10 17 0.00048 0.043 14.4 2.4 2 23 951 973 950 973 0.95
11 17 0.0068 0.61 10.7 2.5 1 23 979 1002 979 1002 0.96
12 17 0.01 0.92 10.2 3.0 2 23 1024 1046 1023 1046 0.95
13 17 0.00096 0.086 13.4 1.3 2 23 1053 1075 1052 1075 0.96
14 17 4.9e-05 0.0044 17.5 1.0 3 23 1084 1104 1082 1104 0.96
15 17 0.001 0.093 13.3 2.3 1 23 1110 1133 1110 1133 0.96
16 17 0.28 25 5.7 3.2 2 23 1140 1161 1139 1161 0.96
17 17 0.0082 0.73 10.5 2.6 1 23 1167 1189 1167 1189 0.98

Sequence Information

Coding Sequence
ATGCAAACTACTGAGGTTGATAATAGAGACCATAATTATAGTGAATTTAAGTCTGATAAACATCAAAATAATGCAAAAGATATGCAGAATACTCATGACGATGATGTGCAAATACTGTTGCCAAAATCTAAGCCAGTACCAGGCAAGGAAATATTTGGTCAAGTTAAAGACATAAAtgaattgaaaaaaataaCACCACGTGTTAAGCTTCTTGCTCACGATGCAACTCGTCTTACTGAATTGACGAAACTTTCTTTGACTAAGAAAGTCCCCATACAAAATAAACATCTGCTCTGGGATCAAACAAAACAAGAGCTAAAAAATTATTGCAGAACCTGTGCCGGACTTAAACTACCATTGGTTGATATTTTCAGTGAGAAAGGAGTACAAATGAGATTAAGTCAGCAAATCAAACACTTAGAGGATATAAATCCATATGATAGTTTATCTACCCAAATGTGTATGGACTGCATTTGTGATTTGAAGATGAGTTACAAattttttatgcaaataaagaAAGCTGAGGTCAGGCTAAAATCTCTCTATCATGCTTTGAGTGAAGctgcagctagaaatattgaaaacaTCAAAACAAGATCAATAACCGATACTTCCATTGAAGATGCTATGGATGAACATATGCGGTCATCGACATCCATGAGTGAGGAAGGTGCAAGTGATTCTGCTGGCCCCAAAATATCAGCAATATATTCCTTGAACAATACACCTATCAAGTCTGAGGAGCCAAGAAAAATAATGGAGACATCTTCACCTTTAGAAACATGTGATGAAATAATTGGACACATTAGTGATGATAATGAATCAATAGAAGAATTTGATCCAGATGATCCTCCATTTCAACCAGATAGTTCCGATGCTGGTGAATCTGATGATGAACTAGATACATGTCATCATCAATCACAGAAAGCGAGGATACAGAAAAAGGAACGACTCAAAGCAATTTCTCAACCAGGTTTCAGTTCATCCACTATTGAGCAAAAAAGTGATGTGAATTTACAAACAACAATTAATGATTCTGGAAATACACATGTTTCGCCTCAAAAAACAGTACCTAAATCAGAACCTGCGCTCAGTAGCGGAACTGCGAAAGAATTTCCAAAGCAACCAAATATTTTAAAACGTAGACTATTAATGCCACCACCTAGAACGGAACAGACAGACCAAGTAAACGATAAAGTCTCCCCTACTAACATATCAGATAAAAATATTGGCCCAAGAGAATTTAAAGTACAAAAGTTGGATATGAACAACCTCTTAAGTATCGATAATGGTCCGGAAGATGGCATTATGTATGTCACTGTTAAGGGCACAAAACCAAATGAATTACTATTAGTGAAAGTTAAAAAAATGGACAAACCTGCTGAAAAAAAGGATGAAAAATGTTTTGCAAAAAAGAGTGttgagaagaaagaaaaggacaTATTTGTGGAAAAGATAAAGCCTGATACTCGAGATCAGATCATAGAGGAGCAAATTGAAGAGTATAAGAAAAAGCGGGAAAAAGTTCTTGGTGGTCATACTGGAAGTAATTTTTCTTTAACACTGGAAGAAAATCAACCACGTTACTTGAAAGCCAATGATAGTAGTTCGAAATCAATGTCATCTGTGGACTCTATAAATTTAGAATCTGGTGCTGAAGATACAGCAATAACACAGTCAAATGATGATTTGGCAGCAGAGGATACTGCAGAGGAGAAACCACCTTCTGAGAAGCTCCATGATAACACATCAGAATGTATATCACGACTTGCAAAATTGAAAGTGAAGTGGGAAGAAGCGAAGAGGAAAAAGGAGTCTTTACAAAGAGAATTGGATGAGTCGTATACAGaaggaaatattgaaaaattggCAAGAATTTTaggtgaaaaagaaaaaaacttACAAGATTTTCAGGATTACCTGAAACAACGGCGAATAGTTATCACACGATTGAAAGACGAAGATATTATTTCCTTGTATGAAGATCGAAATAATGCGCTACTGAGAAACAGTTTACCTGATTTGATAGACGAAACACAACCAGCTGATTATATTCCTGAGGAACATTATTTGGAATGTGATTATTGTCCTCAAACGTTTGCTTCGAAAGAGATATTGGAAGAGCACTTGAAAACTCATGACTACAAAATCATGCATTACTGTGAAGATTGTTCCGAAGTTTTTTCAACGAACAAAGCTAAACGAAATCATAATATCGTTTGTATAAAAAAGTTAATATGTAAATATTGTGATTTGATGTTAGATTCTAAAGGGAAAAAACGGCAACACGAGCAGAAACATTGCGATAGCATGTTTGGGCAACTGTGTGATGTATGTGGTGAGAAATTCAAACATCAGGGGACATTGGACCAGCACATTAAAATGCAACATATGAGTTGGGAGAAGATATTTCAATGCCCAAAATGTCCAAAGAAATTTGCATTCAAACAAAAGCTTAGTTTTCATTTAAAGTCTGTGCATACAACGCTGAGAGCATACTTATGTGAAGACTGTGGGGCAGATTTTAAAAATCCTGCAAGTTTGAGGCACCATCGAATACGGAAACACCAACCGGTCGGAAATAAAAGAGAATGTCCAGTATGTCATAAACTCGTACCATTTTATAGTTTGTCAAAACATATGCACACCCATAAAGCCTACACAATTCAATGTCCACACTGCGACAAGATGTTTAAGAATAGCTCGACACTAAAACAACATGTTAGAATACATGAGGATCAACGGCAATATCGATGTGATACGTGCGGCGTAGGTTTCAATAGACGAGACGGGTTGAGGCTACATATGAGAGTACATGAGAAAACTGACAGTAGAGGATTAAAGGAATGTTCATGCCAAGTGTGTGGGGAGAAATTCCCAAATCATTCCACTCTAGTAATACACAGAAATAGGGTACATAAAGATGGTAGACAATATACATGTCACATATGCAATAGGTCAATGATATCAACGAGATCATTGGAATGGCACATGTCTCATATACATAATGAATCTCTTCCCGGTATCGTAAAAGATGAAGCAGATGGTGCaccagagaaaaagagggtcTCATGTTATCATTGTAATAAAACGTTTAAAACGGAAATGATTCTAAGAACGCATATAAAAAATACGCACATGGAAAAGGACCCAATGAAATGTTTAGATTGCGAATTAACATTTACTTCGGAAGTTCGGCTAAGGCATCATATGATGGTCAACCATAACAGACTAGAAGGAACCTTGGCATGTCCGCACTGCCCGAAGCGATTCGTCAATCAATTACGATTGAAGACACACATGATTTCTCATTCGGAGGAAAGACCTTACACTTGTGAAATATGTggatttaatttgaaaacgAAAATCCAATTAATCAAACATCACCAAAACCGACATAGCGACGAGAGGCCTTTACAATGTAGATATTGCCCTTGGAGGTGTAAACAAGTCAGTGCTCTCGTGTGCCATGAAAGAACTCATACAAATGAGAGGCCCTACTCTTGTAGCGTATGTAGGCAACGCTTCAAGTACTTAGGTGACAAAAATAAGCACGAAAGACGACATGAAAGCCTTGGGGGTTCTGGTTTCAAACGAATAGTCCCAGGTAGAAATATTAAGCCAAAAGTCCAGGAAGAAACTTCCGGTTCTGAGCAAGAGAATGAAGGGCTTGCAAGTGTAGATACTCAATTAACTGAAGAGCAATATGAAGAACGCGAAAGTCAAGAATTCGAGGAACAGATTGTCAAATTTGAACCTCAAGAAATTGTTGGAGAATACGAACAGGAGTATGAGGAAACCTCTAGAGAGGCTTCTGATGCTGCAGAAGTAATAATGAATATGGAAGATACTACTGTTTATACCGAAGAAGTGACTGCTGATAATATAGAGTCTGCAGAAATTATGGCAGATGAGATGATGACGAATGAAATACTACAGTCAGGTACTGTAGTACATCTGCAACAGGAAGATGACTCAGGAAAAATACAAGTAATCCCAGTCATGCTCTCCTTGCCAGATTTGTCTGATGCAAACACAGAAGTCAATCTAGCCACAGCATccattatgtataataattaa
Protein Sequence
MQTTEVDNRDHNYSEFKSDKHQNNAKDMQNTHDDDVQILLPKSKPVPGKEIFGQVKDINELKKITPRVKLLAHDATRLTELTKLSLTKKVPIQNKHLLWDQTKQELKNYCRTCAGLKLPLVDIFSEKGVQMRLSQQIKHLEDINPYDSLSTQMCMDCICDLKMSYKFFMQIKKAEVRLKSLYHALSEAAARNIENIKTRSITDTSIEDAMDEHMRSSTSMSEEGASDSAGPKISAIYSLNNTPIKSEEPRKIMETSSPLETCDEIIGHISDDNESIEEFDPDDPPFQPDSSDAGESDDELDTCHHQSQKARIQKKERLKAISQPGFSSSTIEQKSDVNLQTTINDSGNTHVSPQKTVPKSEPALSSGTAKEFPKQPNILKRRLLMPPPRTEQTDQVNDKVSPTNISDKNIGPREFKVQKLDMNNLLSIDNGPEDGIMYVTVKGTKPNELLLVKVKKMDKPAEKKDEKCFAKKSVEKKEKDIFVEKIKPDTRDQIIEEQIEEYKKKREKVLGGHTGSNFSLTLEENQPRYLKANDSSSKSMSSVDSINLESGAEDTAITQSNDDLAAEDTAEEKPPSEKLHDNTSECISRLAKLKVKWEEAKRKKESLQRELDESYTEGNIEKLARILGEKEKNLQDFQDYLKQRRIVITRLKDEDIISLYEDRNNALLRNSLPDLIDETQPADYIPEEHYLECDYCPQTFASKEILEEHLKTHDYKIMHYCEDCSEVFSTNKAKRNHNIVCIKKLICKYCDLMLDSKGKKRQHEQKHCDSMFGQLCDVCGEKFKHQGTLDQHIKMQHMSWEKIFQCPKCPKKFAFKQKLSFHLKSVHTTLRAYLCEDCGADFKNPASLRHHRIRKHQPVGNKRECPVCHKLVPFYSLSKHMHTHKAYTIQCPHCDKMFKNSSTLKQHVRIHEDQRQYRCDTCGVGFNRRDGLRLHMRVHEKTDSRGLKECSCQVCGEKFPNHSTLVIHRNRVHKDGRQYTCHICNRSMISTRSLEWHMSHIHNESLPGIVKDEADGAPEKKRVSCYHCNKTFKTEMILRTHIKNTHMEKDPMKCLDCELTFTSEVRLRHHMMVNHNRLEGTLACPHCPKRFVNQLRLKTHMISHSEERPYTCEICGFNLKTKIQLIKHHQNRHSDERPLQCRYCPWRCKQVSALVCHERTHTNERPYSCSVCRQRFKYLGDKNKHERRHESLGGSGFKRIVPGRNIKPKVQEETSGSEQENEGLASVDTQLTEEQYEERESQEFEEQIVKFEPQEIVGEYEQEYEETSREASDAAEVIMNMEDTTVYTEEVTADNIESAEIMADEMMTNEILQSGTVVHLQQEDDSGKIQVIPVMLSLPDLSDANTEVNLATASIMYNN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00391491;
90% Identity
iTF_00391491;
80% Identity
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