Basic Information

Gene Symbol
ZEB2
Assembly
GCA_932527285.1
Location
CAKOBM010000031.1:2223229-2225301[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 8.1e-05 0.0048 17.5 1.6 2 21 158 177 157 178 0.94
2 11 2.6 1.6e+02 3.3 0.1 3 23 186 206 185 206 0.89
3 11 0.045 2.7 8.9 0.1 1 23 211 234 211 234 0.93
4 11 0.00015 0.009 16.7 1.6 2 23 240 261 240 261 0.97
5 11 0.076 4.5 8.2 2.9 3 21 266 284 265 285 0.93
6 11 0.00047 0.028 15.1 0.5 2 23 324 346 323 346 0.94
7 11 0.1 5.9 7.8 0.8 3 23 354 373 353 373 0.96
8 11 0.018 1.1 10.1 0.2 1 23 378 400 378 400 0.98
9 11 0.0024 0.14 12.9 1.5 1 23 406 429 406 429 0.94
10 11 0.02 1.2 10.0 0.6 1 20 438 457 438 461 0.92
11 11 0.006 0.35 11.7 4.4 1 23 470 492 470 492 0.97

Sequence Information

Coding Sequence
ATGAGCAGACAAGTCGACATTAAATCTCTGGTGTCACATATCGTTCGAGGAGACGGTTTGGATAAATGCAGAATATGCATGGGAGATACGTCGCAAGGGCAAGTCCACCTAACAGACACGGTCATGATGGATGGAGATAAAGCTGTGACTCTATCCGAACTGCTTGAAGTTATCACTGGAGTCGAGGTGGAGTGCGAAGATGCCCTACCGCCTGTCATATGCCAAACCTGTTTCAACTCTGCTGTTGAAGCAGCTGACTTTCGAAGCCTGGTGCACAGAGCGCAGCTCCAATGGACCAACACCCTTCAGTTGCTAGAGCATGTGCCCCAACACAAATATGATCAGCAGAGTAATACAATAGTAGCCAGTATGTGTGACAATACTATTACAGTGAAAGATGAATGCACAAATCTCCCAGTTGAAAAACCAAAGGAGCAGATCAGAAAAAAATATGGAAAAACGCAAGACTGTCAATGTCCCATCTGTGACAAAAAATTTCCATATGCTACTCTTTTGCATAAGCATTTAAAAGAATCTGCAAATTTAGTTAGAGCATGCTATATCTGTGGAGCAGTGATGAATAGAAATGAATTGGTAAACCACATGGAACAAACACATGGTATCAAACTATTTGCCTGTAAGAAATGCCCGGCTGTGTTTTCCAATGGAAAGCCGTACTTGGAGCATTTGTTCACAGCTCATGCTCCAGGTTGTAGAACCTGCGGAGACTGCAGCCGTTCCTTCAAAAGCCTTTCTGCTTTCCATGCACACCAATCTGTACATGCTAGACGAGCTTGCCCTAATTGTGATAAACAATTTCAAAATCAGATGTGCTACTCCCATCATGTCAAAAAATGCTGTAAAATGGACTCCATGAAAGGCCTCCACAAAAAAAATACCATCACTTTGCAAAACAAAGAAAATAAAATGGTAAAGATGGGTAAGCGTGGCAGTACACACAATACTTGTATATGTGATTATTGTAATAAGACATTTTCTGCAAAGAAATATGTAGCTGCTCACATTGAGATAGTACACACCAAGACCACACATAGACCTTGCCAATCTTGCGGGAAGCTATTTGCTGCTGCCCACATGTCTACACATATGAGATCTCATATGAACCACAGCTACAAGTGCGAGCAGTGTGGTGCCATCCTAAAGAGCAAGCTGGGTTACGACCAGCACTTGAGGTTACATTCCGGAGAACGACCCTACGAGTGTGAACATTGTGGCGAGACGTTCTCGGCTTCTTCCAGACGGTCTGAACATGTGCGCAATAAACACTTCAAGTCTAAAATTATTCTAAAGCATATCTGTAGCTTCTGCCCGGCTAAGTTCAGATTGCCATCCAAGCTTAGGCTGCATATTTGGAAAGTCCATAAATGTAAATCTGACAAACCTGTTCATGAATGTACTGAGTGTTATGAAAAGTTTGCCAGCTTCCGAAGCTTGCAAAACCATTTTAAGAAACATAATTAA
Protein Sequence
MSRQVDIKSLVSHIVRGDGLDKCRICMGDTSQGQVHLTDTVMMDGDKAVTLSELLEVITGVEVECEDALPPVICQTCFNSAVEAADFRSLVHRAQLQWTNTLQLLEHVPQHKYDQQSNTIVASMCDNTITVKDECTNLPVEKPKEQIRKKYGKTQDCQCPICDKKFPYATLLHKHLKESANLVRACYICGAVMNRNELVNHMEQTHGIKLFACKKCPAVFSNGKPYLEHLFTAHAPGCRTCGDCSRSFKSLSAFHAHQSVHARRACPNCDKQFQNQMCYSHHVKKCCKMDSMKGLHKKNTITLQNKENKMVKMGKRGSTHNTCICDYCNKTFSAKKYVAAHIEIVHTKTTHRPCQSCGKLFAAAHMSTHMRSHMNHSYKCEQCGAILKSKLGYDQHLRLHSGERPYECEHCGETFSASSRRSEHVRNKHFKSKIILKHICSFCPAKFRLPSKLRLHIWKVHKCKSDKPVHECTECYEKFASFRSLQNHFKKHN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00686731;
90% Identity
-
80% Identity
-