Basic Information

Gene Symbol
-
Assembly
GCA_932527285.1
Location
CAKOBM010000038.1:492697-495898[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 1.1 67 4.5 2.7 1 23 181 203 181 203 0.94
2 10 0.15 9.2 7.2 0.1 2 21 231 250 230 251 0.94
3 10 0.00031 0.018 15.7 0.6 3 23 277 297 275 297 0.97
4 10 2.4e-06 0.00014 22.3 0.2 1 23 301 323 301 323 0.98
5 10 0.22 13 6.7 0.5 1 23 328 351 328 351 0.94
6 10 0.19 11 7.0 0.5 1 23 357 380 357 380 0.92
7 10 7e-05 0.0041 17.7 0.7 1 23 387 410 387 410 0.98
8 10 0.0001 0.0059 17.3 2.4 1 23 416 438 416 438 0.98
9 10 7e-06 0.00042 20.9 3.4 1 23 444 466 444 466 0.98
10 10 1.3e-06 7.6e-05 23.2 0.9 1 23 472 494 472 494 0.98

Sequence Information

Coding Sequence
ATGGACTCAGTTGAAATAATGGTGGAGGCGCTGCCCTTACTGGGCGTTTGTAATTTGTGTTTAAATGAAGGGGCAGTGCAAAGTATGTTGGTAGCCCATCAACTTGGTACCTCGACAGAGATTTACGCCGACTTGCTCATGAAATGCTTCGCTATTGACATCACATTGTTGGAGTATGGTGACACAAAGAGGTTGATATGCAGGGACTGTGCTGACAAGCTCTGTTCCACCAAACAGTTTCGACTTCAAGTGGAGGGTTCCCTTGCAGCACTCGAGGCTGCCTACAAGATCCAGAAAGCCACAAGCACTTCGGTGGTGAAGGAGGAATTGGATTTTGATGACCCCGATTATGATATAGAGCTGCCTGATGATGATAGTGATGAAGACTACAAAATACCAATAAAACTGGAACAGGAGAATGGACCTGTAAAAAAACTCAAGAAAACAAAGAAACTCAAGAAAAAAACTCACGACACGCGAGAAACGGACGCGATGCTACAGCAAGGACTATTCCCCTTCAAAATCAAGCGGAACCAGATCTACTCGTGCACCATCTGCCCGCACAAGTCCACTGTACTCGAGGAACTTAAGTGTCACATCACCCAACACACAAAGAGCAACATACAGATTGCATTCAAAAAGATGATGTTCTCCGACTCCCACCGCTTCTACAAAACATCCACCAAGCTACGTTGCAAGATCTGCACCTCGGACGTATCAAACTTCGAAGAACTCAACGCTCACATTCAAAACTGCACTAGAATCAAGCACAATAATGGAAGCAAATGGAATAATTtacctttcaaactggaaaaagaccaaaccgactgtccggtttgcaagaaacggttcctaaacttcgtcaatctcaacacgcacatgaatatccactaccctgattatatatgcgagagttgcggcaaggcgttcgcgtcgaaggcgaggctgcgggggcatatgaggacacacgaagaaggcagcttcccgtgtcggtactgctcggctgtgttcgaccgggtcaccaaacgggagaaccacgtttctaaggaacataaagccggggtccgatacgcttgcaaacgctgcaacctctccctaacgtcattctacgctcgacagaagcatctagccgaggtccacaacgaggaattgaaacgatacaagtgcaaagcctgtccccaaagttatataactcccggacacttatccagtcacgtgagaagggatcatctaaatgaaaggaaccaccggtgtgataaatgtgacttggcgttctacacgaaaaacgctctgaaaatgcatcagataaaacacgacggggaacgaatacacgtttgcagtatctgccagaaatcttatcagaggaaaaaaactttacgtgaacatatgaggatacataacaatgataagaggtttatttgtccggtgtgcgggcgtgctttcactcagaaatgcacattgaaaggacacTTACGAGTGCACGACAGGAAAGTTGACTTGGACGAAAGAGTGGTGGGACAGCCGCTACATTCTATATGA
Protein Sequence
MDSVEIMVEALPLLGVCNLCLNEGAVQSMLVAHQLGTSTEIYADLLMKCFAIDITLLEYGDTKRLICRDCADKLCSTKQFRLQVEGSLAALEAAYKIQKATSTSVVKEELDFDDPDYDIELPDDDSDEDYKIPIKLEQENGPVKKLKKTKKLKKKTHDTRETDAMLQQGLFPFKIKRNQIYSCTICPHKSTVLEELKCHITQHTKSNIQIAFKKMMFSDSHRFYKTSTKLRCKICTSDVSNFEELNAHIQNCTRIKHNNGSKWNNLPFKLEKDQTDCPVCKKRFLNFVNLNTHMNIHYPDYICESCGKAFASKARLRGHMRTHEEGSFPCRYCSAVFDRVTKRENHVSKEHKAGVRYACKRCNLSLTSFYARQKHLAEVHNEELKRYKCKACPQSYITPGHLSSHVRRDHLNERNHRCDKCDLAFYTKNALKMHQIKHDGERIHVCSICQKSYQRKKTLREHMRIHNNDKRFICPVCGRAFTQKCTLKGHLRVHDRKVDLDERVVGQPLHSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00361900;
90% Identity
iTF_00737732;
80% Identity
-