Basic Information

Gene Symbol
ham
Assembly
GCA_027574945.2
Location
JAODGD020036811.1:9099-22809[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.13 21 6.3 0.5 2 23 459 481 458 481 0.93
2 9 0.0019 0.29 12.1 0.4 1 23 488 511 488 511 0.93
3 9 1.3e-08 1.9e-06 28.4 3.9 1 23 517 539 517 540 0.96
4 9 4e-06 0.00062 20.6 2.6 1 23 546 568 546 568 0.95
5 9 1.2e-05 0.0019 19.0 4.9 1 23 574 596 574 596 0.99
6 9 0.016 2.5 9.2 0.7 2 21 602 623 601 624 0.90
7 9 1.8e-09 2.7e-07 31.1 0.6 1 23 924 946 924 946 0.98
8 9 1.1e-06 0.00017 22.4 1.6 1 23 952 975 952 975 0.97
9 9 2.5e-06 0.00038 21.2 3.4 1 23 981 1003 981 1003 0.99

Sequence Information

Coding Sequence
ATGCTCGAGGTCGGCGATGATGCGCCGCGCGCGCCGCATCCTTCGGGATCCTCAGGCCACGCCCCGCGCGCGCATCCCCACCCCGGTCGCGGCGTGCGTGAGCGTTGCGTGAAGCGCCCCGGCGACAGCGAGATGCGCCGAGGGATGGGCCTCGGCGCGGCCCAACCGAAGGCGGCGGCGCGAGCGAGCGCGCCGCCGCGCGCCGAAGCGAGACGGCCGGCGCGTCGAGGATGCACGCCCGGATTCGGGATGACCGGGATAGCCGGGCCGGGGCAGCGCCGATGCCCGGCGACGCGGCGCCCGGCGCGCCGCCTGCATCTTCAGTCAGTCGCTGTCTGTCGTCGGCGACGCTCGCACGCACGCACGCCTTGCACCAACCCTCTGCGCGAGGCAGGGCGCGAGACACTCCGCACGGGCGCGCACGCGCGCACGGGGCGCGACCCGATCATCTCGAGACCTCATCCGCGCCGAATCCGGCCCATCAGTGCCGGCGCACAGCTCGCGCCCGACAAGGGCAGCGAGGATGAAATCGAGCTGGAAGTGAGCAACCACGAGGCCATCGAGCGCGGCGGCGGCGGCGGCGGCGAGGGCGACCGGGGCGACGGCGAGCGGCGATCCGCGATGGCGCTGGACAACAACAACGAGGGCGGCAGGAAGAGCCTCCTCAGCGTGAAGCTGCCGTCCGAGCTGTTCGCGGGCGGCGGCTGCGGCTACCCGCCTCACGCCCCCGACGCGGCCAGCTACAATCAGTTCCTGGAGAAGGCGAAGAAGCTCGTCGCCGAGGAACTGCTCAGCTCGGCGGAGTATTACAACCTGTTTCCGGTCCTGCAGCCCGGCGGCCATGCGCCGGTCTCGACGGCCACCAGCAACGGCTACAGCCTGTACGGCCTGCTGCCCCCGGAAGTGGAGCTGCGCAAGGACGGCGTGTTCGCCAAAACCGTCATACCCAAGGGCACCAAGTACGGCCCGTTCGAGGGCAAGTGGGCGACGCAGCCGCACGACGCGAAATTCGCATGGGAGGTGCATCTACCCAATGGCAACAGCGAGAGCAGGACGGGCTACTTGGACGGTTCCAACGAGCACCGGAACTGGATGAAGTTCATCAAGCCGGCGCCCAGCAAAACGTCCGCCAACACTACTCACATGATCCAGGGTGGTCAGCTGTGGTACACTACAATCCGAGATATCCAGCAGGGATGCGAATTCGTCCTGGAACCCAAGGAAGCTTTGAACTTCCAGGAGATGTACGGGTATTCCGTCACCTCGGACGATCGCAGCGACAGGGAGACCGCATCGCAACACAGTGGCACCGTCGAGGACGAGAGCAACGACGTTTGTCGAAACAATCCCGAGGAAGACGAGGACTCCGAGACTCGCTGTTGCGTCTGCGACCTGCCCTTCAACGATATTGAAACATTGGACGAGCACCTGATCCAGAAGCACAGTTACAGGCGCGGCGAGTTCCGCTGCGACTTGTGTCCGAGGGCGTACGCGTACAAACCCTGCCTGATCCGCCATCGAGGCATCGTTCACGGGGAGCATCGCAAGTATCACTGCGAGAACTGCGACAAGGTCTTCACCGATCCCAGCAACCTTCAGCGCCACATACGCAAGCATCACGAGGGCGCGCGATCGCACGCGTGCACCGAGTGCGGCAAGACGTTCGCCACCTCTTCGGGTCTGAAGCAGCACACGCACATCCACTCGAGCGTGAAGCCCTTCCAGTGCGACGTGTGCTTCAAGGCGTACACGCAATTTTCCAACCTCTGCCGCCACCGACGCATGCACGCGGACTGTCGCATTCAGTGCAAGTGCATCAAGTGCGGCCAGAGCTTCGGCACGGCGATGGCGCTGTCGAAGCACAGCCGCTTCTGCGACTCCGCGAACCCGCCGCCGGCGCCCATGCAACCGCAGAACGCGCCCAGCTCGAACATGCCCAACGCCGCCCAGATGAATCAGAACGTCTTTCGGCCCCAGCGAATGTTCTTCCCGTACCATCCGTACCTGGGCAGTCAAATGATCCAAGTGTATCCCGGCTTCAACCCTACCCTCCTCCTGAGGAAGCTGCAGGCCGACCAACTTGCGGCCGGGCTGCTGTTTCAGGACGAGCCCATGAACCAACCACCGCCGAAAATGAACGCCGGAAAGGGCGACGCGCAGCATAACATCAAGGACGAGATGAAACCTGTCAAGGTCAAGGTCGAGGCGTACGATGACGATGCGCCCAGGGATCTCTCCAAGAGCGGCGCGAAGGACTTCGAGGACAAGAGCCTAACGCCCGTCAAAGTCGAGAAGGAAGATAAACCATTGGACCTCAGTTGGAAGAAGGAAGACAATCAGAAGGAGAAACCCGCGAGCGTTGATCAGGACGTGAAGATGGAATTGAAGCGCGAAGACTCCAAGAGCCCCGAACGGTTTCCTCCCGCGGAGGAGAAAAGCTTCATGCACCCGTCTTTCGCCAAAGAGCCGGAGAAAGTCGACCTGCCCACCTTGTTCAACCCGCGCCCGATTCATCCCATGACCCTGTTGGACTACTACCGTCCGCACTTCTCGTTTCCGGCGGCGTCATCGCCCGACCGCCTGCTGGGGCCGGCGTTTCCCCCTCGCCTGGGATCCCATCTTTCGCACATGAGCGCCCAAGCTCAATCCCGTCTGGACATGATGCGGCCGGCGTTCCACCACCTGTCGCCGCCCTTGCCGGCGCCGCATCACGCCATGGGCGCCCCGGCGTTGGCCCTGCCGCCGGGCGGCGGCAAAATCAAAGATCGATACGCCTGCAAGTACTGCGGCAAGGTGTTCCCGCGCTCGGCGAACCTTACGCGCCACCTTCGCACGCACACTGGCGAGCAGCCGTACAAGTGTCGCTACTGCGAGCGCTCCTTCTCGATCTCCTCCAACCTGCAGCGACACGTGCGCAACATACACAACAAGGAGAAGCCGTTCAAGTGTCCGCTGTGCGACCGCTGCTTCGGCCAGCAGACGAACCTCGACCGCCATCTGAAGAAGCACGAGGCGGACGAGGCCGGCGTGCCGTTGGCCGACTCGCCTGGATCCAGCACCGAGAACGATCGCGAGGACGTCGATCGCGAGGACGCCTGCGAGGAGATGCGCACGTTCATGAACAAAGTCACCGGCGGCGCGCACGACCCCTTCCGGCTGTACCTCTCGCCGCCCAGCGCCGACAAGGACGACCACGGCATCGAGGAGGACGACGAAGAAAACAGCTACGGCTCCGCCGTCGAGGATCTCTCCAAGTTCCGCTGCTCGGCGAGTTCGCGCGATGCCAAAGAGAAGCTCGACGCGCAGATCAACAACAACAATCCGATGACGAGCACCGTCGCGTTTTAA
Protein Sequence
MLEVGDDAPRAPHPSGSSGHAPRAHPHPGRGVRERCVKRPGDSEMRRGMGLGAAQPKAAARASAPPRAEARRPARRGCTPGFGMTGIAGPGQRRCPATRRPARRLHLQSVAVCRRRRSHARTPCTNPLREAGRETLRTGAHARTGRDPIISRPHPRRIRPISAGAQLAPDKGSEDEIELEVSNHEAIERGGGGGGEGDRGDGERRSAMALDNNNEGGRKSLLSVKLPSELFAGGGCGYPPHAPDAASYNQFLEKAKKLVAEELLSSAEYYNLFPVLQPGGHAPVSTATSNGYSLYGLLPPEVELRKDGVFAKTVIPKGTKYGPFEGKWATQPHDAKFAWEVHLPNGNSESRTGYLDGSNEHRNWMKFIKPAPSKTSANTTHMIQGGQLWYTTIRDIQQGCEFVLEPKEALNFQEMYGYSVTSDDRSDRETASQHSGTVEDESNDVCRNNPEEDEDSETRCCVCDLPFNDIETLDEHLIQKHSYRRGEFRCDLCPRAYAYKPCLIRHRGIVHGEHRKYHCENCDKVFTDPSNLQRHIRKHHEGARSHACTECGKTFATSSGLKQHTHIHSSVKPFQCDVCFKAYTQFSNLCRHRRMHADCRIQCKCIKCGQSFGTAMALSKHSRFCDSANPPPAPMQPQNAPSSNMPNAAQMNQNVFRPQRMFFPYHPYLGSQMIQVYPGFNPTLLLRKLQADQLAAGLLFQDEPMNQPPPKMNAGKGDAQHNIKDEMKPVKVKVEAYDDDAPRDLSKSGAKDFEDKSLTPVKVEKEDKPLDLSWKKEDNQKEKPASVDQDVKMELKREDSKSPERFPPAEEKSFMHPSFAKEPEKVDLPTLFNPRPIHPMTLLDYYRPHFSFPAASSPDRLLGPAFPPRLGSHLSHMSAQAQSRLDMMRPAFHHLSPPLPAPHHAMGAPALALPPGGGKIKDRYACKYCGKVFPRSANLTRHLRTHTGEQPYKCRYCERSFSISSNLQRHVRNIHNKEKPFKCPLCDRCFGQQTNLDRHLKKHEADEAGVPLADSPGSSTENDREDVDREDACEEMRTFMNKVTGGAHDPFRLYLSPPSADKDDHGIEEDDEENSYGSAVEDLSKFRCSASSRDAKEKLDAQINNNNPMTSTVAF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00632265;
90% Identity
iTF_00632265;
80% Identity
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