Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3.5e-05 0.0035 17.9 0.2 1 20 14 33 14 34 0.95

2 6 0.0021 0.21 12.3 1.7 1 23 48 71 48 71 0.96

3 6 0.00014 0.014 16.0 0.1 2 23 79 100 78 100 0.96

4 6 4.7e-06 0.00047 20.7 1.9 1 23 106 128 106 128 0.97

5 6 1e-08 1e-06 29.0 0.9 1 23 134 156 134 156 0.98

6 6 0.00015 0.015 15.9 0.2 1 21 162 182 162 183 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3.5e-05	0.0035	17.9	0.2	1	20	14	33	14	34	0.95
2	6	0.0021	0.21	12.3	1.7	1	23	48	71	48	71	0.96
3	6	0.00014	0.014	16.0	0.1	2	23	79	100	78	100	0.96
4	6	4.7e-06	0.00047	20.7	1.9	1	23	106	128	106	128	0.97
5	6	1e-08	1e-06	29.0	0.9	1	23	134	156	134	156	0.98
6	6	0.00015	0.015	15.9	0.2	1	21	162	182	162	183	0.93

Coding Sequence: TTCGAGGAACACGCCAACATTCACAGCGGTGAAAATCCGTACCAATGCGACGTTTGCGACAAAGCGTTTCCATACTCGCAGTACTTATCGGCGCACAAGTCCTGCATGCACACCGAAAAGCAGAACGATAGCACAGTGAAGCACGAGTGCTTAATTTGCAAGAAGACTTATCCTAGCCGCGGCATTTATAATGCGCACATGAAGTATAAACACATGGGCCAAAATCGATCAATTGTTTGCGATGTGTGCGGGAAGACTTTGGCCAACAAGGAAAAGTTGGGCTTACATTATCGCGCCCACACCGGGTATAAACCCTTCAACTGTCAACATTGTGGCAAGGCGTTTACCAAGAGGGAATTCTTGGTGGAGCATGAGCGAATTCATACAGGCGAGAAACCATTTGTATGTCAGGAATGTGGAAAGGGTTTCTCGCAGCGGTCAAGCCTCAAGATTCACACCAGGAGTCACACCGGCGAACGCCCGTTTGTATGCCACATTTGCAATAAGGGTTTCGTTGCAAGAGCATTATTGAATGTGCATTTCAAATCGTGCAAGGGATATGAATAG
Protein Sequence: FEEHANIHSGENPYQCDVCDKAFPYSQYLSAHKSCMHTEKQNDSTVKHECLICKKTYPSRGIYNAHMKYKHMGQNRSIVCDVCGKTLANKEKLGLHYRAHTGYKPFNCQHCGKAFTKREFLVEHERIHTGEKPFVCQECGKGFSQRSSLKIHTRSHTGERPFVCHICNKGFVARALLNVHFKSCKGYE

Sequence clustering based on sequence similarity using MMseqs2